DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and GZMH

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_219491.1	Gene:	GZMH / 2999	HGNCID:	4710	Length:	246	Species:	Homo sapiens

Alignment Length:	273	Identity:	75/273 - (27%)
Similarity:	117/273 - (42%)	Gaps:	46/273 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LALIGLVLCQGLAQLLDKKCHDPKTSENINFNHGATETAPWMASIYKNNQFI-------CDGTLV 64
            |.|:..:|..|..           |.|.|..:.....:.|:||.:    ||:       |.|.||
Human     5 LLLLAFLLTPGAG-----------TEEIIGGHEAKPHSRPYMAFV----QFLQEKSRKRCGGILV 54

  Fly    65 HKLFVLTAASCISKDSQLYVLFGMYN-QYRDASQFFNNEQYGVAVALQHSNFRPNNGVNDIGLLR 128
            .|.||||||.|  :.|.:.|..|.:| :.::.:|.|    ..|...:.|..:.|.|..|||.||:
Human    55 RKDFVLTAAHC--QGSSINVTLGAHNIKEQERTQQF----IPVKRPIPHPAYNPKNFSNDIMLLQ 113

  Fly   129 LYGEVTHYAHIRPICIILDHV-VKSAPFERFEGFGWQQQGTEASSQVRQTVYLSQKKPFECHR-- 190
            |..:......:||:.:..... ||........|:|:....|.|::  .|.|.|:.:|..:|.|
Human   114 LERKAKWTTAVRPLRLPSSKAQVKPGQLCSVAGWGYVSMSTLATT--LQEVLLTVQKDCQCERLF 176

  Fly   191 NGQLLPINEGQFCAGN--RDRSFCRSNSGSPLTADFTYGVKNITVQVGLVSYGSELCSPTSVYTD 253
            :|......|  .|.|:  :.::..:.:||.||...        .|..|::|||::..:|..||..
Human   177 HGNYSRATE--ICVGDPKKTQTGFKGDSGGPLVCK--------DVAQGILSYGNKKGTPPGVYIK 231

  Fly   254 VVAFKDWIYNTVR 266
            |..|..||..|::
Human   232 VSHFLPWIKRTMK 244

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	67/230 (29%)
		Tryp_SPc	46..261	CDD:214473	65/227 (29%)
		Tryp_SPc	293..484	CDD:304450
		Tryp_SPc	293..481	CDD:214473
GZMH	NP_219491.1	Tryp_SPc	21..242	CDD:238113	68/242 (28%)
GZMH	NP_219491.1	Mediates the preference for acidic residues at the P3' and P4' sites	46..48		0/1 (0%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910