DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and KLK5

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_001070959.1	Gene:	KLK5 / 25818	HGNCID:	6366	Length:	293	Species:	Homo sapiens

Alignment Length:	317	Identity:	82/317 - (25%)
Similarity:	120/317 - (37%)	Gaps:	100/317 - (31%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 VLCQGLAQLL-----------DKKCHDPK----TSENINFNHGATE------------------- 43
            |||..:..||           |..|..|.    :..|.:...||.|
Human    11 VLCALITALLLGVTEHVLANNDVSCDHPSNTVPSGSNQDLGAGAGEDARSDDSSSRIINGSDCDM 75

  Fly    44 -TAPWMAS-IYKNNQFICDGTLVHKLFVLTAASCISKDSQLYVLFGMYN---QYRDASQFFNNEQ 103
             |.||.|: :.:.||..|...|||..::||||.|..|  ...|..|.|:   .|....|.|.
Human    76 HTQPWQAALLLRPNQLYCGAVLVHPQWLLTAAHCRKK--VFRVRLGHYSLSPVYESGQQMFQ--- 135

  Fly   104 YGVAVALQHSNFRPNNGVNDIGLLRLYGEVTHYAHIRPI------------CIILDHVVKSAPFE 156
             ||. ::.|..:......||:.|::|...:.....:|||            |::
Human   136 -GVK-SIPHPGYSHPGHSNDLMLIKLNRRIRPTKDVRPINVSSHCPSAGTKCLV----------- 187

  Fly   157 RFEGFGWQQQGTEASSQVR--------QTVYLSQKKPFECHRNGQLLPINEGQFCAGNR-DRSFC 212
                .||   ||..|.||.        ....||||:..:.:..    .|::..||||:: .|..|
Human   188 ----SGW---GTTKSPQVHFPKVLQCLNISVLSQKRCEDAYPR----QIDDTMFCAGDKAGRDSC 241

  Fly   213 RSNSGSPLTADFTYGVKNITVQVGLVSYGSELCSPTS---VYTDVVAFKDWIYNTVR 266
            :.:||.|:       |.|.::| ||||:|...|:..:   |||::..|..||..|::
Human   242 QGDSGGPV-------VCNGSLQ-GLVSWGDYPCARPNRPGVYTNLCKFTKWIQETIQ 290

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	68/245 (28%)
		Tryp_SPc	46..261	CDD:214473	66/242 (27%)
		Tryp_SPc	293..484	CDD:304450
		Tryp_SPc	293..481	CDD:214473
KLK5	NP_001070959.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	37..68		5/30 (17%)
KLK5	NP_001070959.1	Tryp_SPc	66..285	CDD:214473	67/255 (26%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910