DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and F10

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_000495.1	Gene:	F10 / 2159	HGNCID:	3528	Length:	488	Species:	Homo sapiens

Alignment Length:	272	Identity:	72/272 - (26%)
Similarity:	118/272 - (43%)	Gaps:	38/272 - (13%)

- Green bases have known domain annotations that are detailed below.

  Fly    21 LLDKKCHDPKTSENINFNH--GATE----TAPWMA-SIYKNNQFICDGTLVHKLFVLTAASCISK 78
            |||.....|:..:| |...  |..|    ..||.| .|.:.|:..|.||::.:.::||||.|:.:
Human   217 LLDFNQTQPERGDN-NLTRIVGGQECKDGECPWQALLINEENEGFCGGTILSEFYILTAAHCLYQ 280

  Fly    79 DSQLYVLFGMYNQYRDASQFFNNEQYGVAVALQHSNFRPNNGVNDIGLLRLYGEVTHYAHIRPIC 143
            ..:..|..|..|..::..   ....:.|.|.::|:.|.......||.:|||...:|...::.|.|
Human   281 AKRFKVRVGDRNTEQEEG---GEAVHEVEVVIKHNRFTKETYDFDIAVLRLKTPITFRMNVAPAC 342

  Fly   144 IILDHVVKSAPFER----FEGFGWQQQGTEASSQVR--QTVYLSQKKPFECHRNGQLLPINEGQF 202
            :......:|....:    ..|||...:....|::::  :..|:.:.   .|..:...: |.:..|
Human   343 LPERDWAESTLMTQKTGIVSGFGRTHEKGRQSTRLKMLEVPYVDRN---SCKLSSSFI-ITQNMF 403

  Fly   203 CAG--NRDRSFCRSNSGSPLTADF--TYGVKNITVQVGLVSYGSELCS---PTSVYTDVVAFKDW 260
            |||  .:....|:.:||.|....|  ||.|      .|:||:| |.|:   ...:||.|.||..|
Human   404 CAGYDTKQEDACQGDSGGPHVTRFKDTYFV------TGIVSWG-EGCARKGKYGIYTKVTAFLKW 461

  Fly   261 IYNTVRNFETKG 272
            |   .|:.:|:|
Human   462 I---DRSMKTRG 470

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	61/231 (26%)
		Tryp_SPc	46..261	CDD:214473	59/228 (26%)
		Tryp_SPc	293..484	CDD:304450
		Tryp_SPc	293..481	CDD:214473
F10	NP_000495.1	GLA	25..85	CDD:214503
		EGF_CA	86..122	CDD:238011
		FXa_inhibition	129..164	CDD:317114
		O-glycosylated at one site	183..203
		Tryp_SPc	235..464	CDD:238113	63/245 (26%)
		O-glycosylated at one site	476..485
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910