DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and AgaP_AGAP012020

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_320509.4	Gene:	AgaP_AGAP012020 / 1280648	VectorBaseID:	AGAP012020	Length:	753	Species:	Anopheles gambiae

Alignment Length:	554	Identity:	132/554 - (23%)
Similarity:	216/554 - (38%)	Gaps:	145/554 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    26 CHD-----PKTSENINFNHGATETAPWMASI----YKNN-----QFICDGTLVHKLFVLTAASCI 76
            ||:     .|........||.|......:.|    :||:     :::|.|:|:.:.|:||||.|.
Mosquito     2 CHERFFKQKKIKPIAEVFHGITANLDDFSHIAAIGWKNDDRTRTKWLCGGSLIRENFILTAAHCT 66

  Fly    77 SKDSQL---YVLFGMYNQYRDASQFFNNEQYGVAVALQHSNFRPNNGVNDIGLLRLYGEVTHYAH 138
            :.::..   ....|..|.|.:|...:..|...|.| ::|.|::..:...||.|::|...|:...:
Mosquito    67 ADENNTPPDVARMGDLNIYSNADNEYAQELKIVDV-IRHPNYKFTSSYYDIALMKLERNVSVTRY 130

  Fly   139 IRPICIILDHVVKSAPFERFEGFGWQQQG-TEASSQVRQTVYLSQKKPFEC----------HRNG 192
            :.|.|:.|:..::   |......||.:.| :|.:|::...|.||..:..:|          :|||
Mosquito   131 VIPTCLWLEDEIR---FPNLMAAGWGRTGFSENTSEILMKVQLSPVREDKCLKHYRKGDYKYRNG 192

  Fly   193 QLLPINEGQFCAGNRDRSFCRSNSGSPLTADFTYGVKNITVQVGLVSYGSELCS--PTSVYTDVV 255
            .|    :.|.|||:.:...|..:||.||........|.:...||:.|:| ::|.  ...||..|.
Mosquito   193 LL----DHQLCAGDEEMDTCPGDSGGPLHVMLLKDKKLVPFLVGVTSFG-KICGVPAPGVYIKVS 252

  Fly   256 AFKDWIYNTV-------------------RNFETKGDQVVY-------------EECRSNWAEDV 288
            .|.|||..|:                   |.:|.:.|..::             |...:......
Mosquito   253 KFGDWIIETLQRYGEMATRLKFDPMICSDRYYEEREDDKIFGFSPKGNVLLPYIELYTAQQTSSS 317

  Fly   289 LVRL-W--EVSLHQNTFSGVLITNRFVLTVA------SAFPNIPLVMKVETKYLKSFDVESIHTH 344
            |:|. |  |||......||.||....|||:|      .::|.     :|..|.....|:..|..|
Mosquito   318 LIRFGWPHEVSPGNRNCSGTLIEPNVVLTLAECVFHMGSYPT-----QVVLKNRNIIDIAEIIVH 377

  Fly   345 PRFTHSSMD---NNIALLKLAHDVPNSDLVKPIC-----------IVPSPKLPRMLTTLVDETTN 395
            |.: :||:.   ||||::||....|    |:|.|           ::.:.:.||:.|.:.
Mosquito   378 PLY-NSSISPYYNNIAVVKLKSFAP----VEPSCAWYGNPNRNKKLLVTGQQPRVSTLMA----- 432

  Fly   396 DFRGVRNVTLNAINHIECARRIGKPLKSNQFCVAQPIDFKVQ----------APGS---IIGTYR 447
               .||.            |...:.|.:.|:..:.|.|.:.:          .|||   :.|:..
Mosquito   433 ---SVRE------------RSSKQCLLTQQYLDSLPRDLEDEHLCYENDPFIVPGSCDTLKGSPI 482

  Fly   448 NIGDGNRYYLFGLMSYSKDGMVVYTYIQSYLDWI 481
            ...||..||.....|::.      |::  |:|.|
Mosquito   483 ERNDGIDYYHLFAFSFNT------TFV--YIDGI 508

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	65/242 (27%)
		Tryp_SPc	46..261	CDD:214473	63/239 (26%)
		Tryp_SPc	293..484	CDD:304450	54/224 (24%)
		Tryp_SPc	293..481	CDD:214473	53/222 (24%)
AgaP_AGAP012020	XP_320509.4	Tryp_SPc	17..258	CDD:214473	66/249 (27%)
		Tryp_SPc	18..261	CDD:238113	68/251 (27%)
		Tryp_SPc	317..536	CDD:304450	56/230 (24%)
		Trypsin	323..533	CDD:278516	54/224 (24%)
		Tryp_SPc	641..>732	CDD:304450
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.910