DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and AgaP_AGAP008911

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_319658.4	Gene:	AgaP_AGAP008911 / 1279878	VectorBaseID:	AGAP008911	Length:	579	Species:	Anopheles gambiae

Alignment Length:	586	Identity:	126/586 - (21%)
Similarity:	225/586 - (38%)	Gaps:	128/586 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 LALIGLVLCQGLAQLLDKKCHDPKTSENINFNHGATETA--PWMASIY----KNNQFICDGTLVH 65
            |.|:..:..|...|||   |...|...|...|:|.....  ||.|:||    :..::.|.|:::.
Mosquito    15 LYLVTQIRGQDEDQLL---CGRRKVQTNSMNNNGDAIAGHWPWYAAIYHRKGEKQEYACGGSILD 76

  Fly    66 KLFVLTAASCISKDSQLY------VLFGMYNQYRDASQFFNNEQYGVAVALQHSNFRPNNGVNDI 124
            :..:|||::|:...|.:.      |..|..:. :.||.:  .:.|.|...:.|..|...:.:|||
Mosquito    77 ETTILTASNCVYTPSGVISAALVTVHVGQIHP-KQASAY--AQMYDVREIVVHPGFSEASTINDI 138

  Fly   125 GLLRLYGEVT-HYAHIRPICI-ILDHVVKSAPFER--FEGFGWQQQGTEASSQVRQTVYLSQKKP 185
            .|::|...:| ...:::|:|: .:|..::......  ..|||..::....|.:..|...:....|
Mosquito   139 ALIKLTASITLTTEYVQPVCLWTMDSALELIVGRNGTVVGFGPNERRDVVSGEQLQQATIGVVDP 203

  Fly   186 FECHRN-----GQLLPINEGQFCAG--NRDRSFCRSNSGSPLTADFT--YGVKNITVQVGLVSYG 241
            ..|..:     |..||:.  .||..  ......|..:||..|..:.:  :.|:.:..::..|...
Mosquito   204 QTCIASDPAIFGTHLPVE--TFCGKGLQNGAGACNGDSGDGLFFEVSGQWFVRGLVARLQPVRES 266

  Fly   242 SELCSPT--SVYTDVVAFKDWI-----------YNTVRNFETKGDQVV-----YEECR-----SN 283
            ..||.|.  :|||||..:.|||           .|.|.....:.::.:     ::.|.     :.
Mosquito   267 DGLCDPLQYTVYTDVAKYVDWIKRYVDPRVLPVENGVLTMGVEHEEKLRRLFNFDSCGLTSSVAL 331

  Fly   284 WAEDVLVRLW--EVSLHQNTFS----GVLITNRFVLTVASAF----PNIPLVMKVETKYLKSFD- 337
            :.:..|...|  |..:..|..|    ..||::|:.:..|..|    |.|.|...|...||:.:.
Mosquito   332 YGQHNLTLPWLGEAMVPPNADSVRCIVTLISDRYAVGPAHCFVGGTPYISLDSVVLNDYLECYSN 396

  Fly   338 ---------------VESIHTHPRFTHSSMDNNIALLKL------AHDVPNSDLVKPICIVPSPK 381
                           ::.:..||.:..::..:||||::|      :|  ||   |.|||:...|:
Mosquito   397 GNESSTCTALKQKRKIQRVIVHPNYGQNNSTDNIALIELLSPANTSH--PN---VLPICMPVMPE 456

  Fly   382 LPRMLTTLVDETTNDFRG--VRNVTLNAINHIECAR------------------RIGKPLKSNQF 426
            |.....|.:...|.:..|  .:||.:..:...||.:                  .:.:..:..:.
Mosquito   457 LRTQTKTNLHVATAEMHGAVAKNVPVRYLEPDECTKVYAEEQIVLNLDLHKRLCAVVESWEDEEA 521

  Fly   427 CVAQPIDFKVQAPGSIIGTYRNIGDGNRYYLFGL----MSYSKDGMVVYTYIQSYLDWIMDKVYY 487
            |       |....|:.:...:..|...:|:|.|.    ::.......:|..|:.|:|||:    |
Mosquito   522 C-------KPLVAGAPLQEMKLFGGKEQYFLRGFELAGLACRSSAPAIYHCIEPYVDWIL----Y 575

  Fly   488 N 488
            |
Mosquito   576 N 576

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	58/253 (23%)
		Tryp_SPc	46..261	CDD:214473	56/239 (23%)
		Tryp_SPc	293..484	CDD:304450	51/246 (21%)
		Tryp_SPc	293..481	CDD:214473	49/243 (20%)
AgaP_AGAP008911	XP_319658.4	Tryp_SPc	359..573	CDD:304450	45/225 (20%)
		Tryp_SPc	46..290	CDD:238113	58/248 (23%)
		Tryp_SPc	46..288	CDD:214473	56/246 (23%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG26899
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.920