DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and AgaP_AGAP008403

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_317049.4	Gene:	AgaP_AGAP008403 / 1277577	VectorBaseID:	AGAP008403	Length:	873	Species:	Anopheles gambiae

Alignment Length:	519	Identity:	120/519 - (23%)
Similarity:	191/519 - (36%)	Gaps:	112/519 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    59 CDGTLVHKLFVLTAASCISKDSQL---YVLFGMYNQYRDASQFFNNEQYGVAVALQHSNFRPNNG 120
            |.|:|:.:.:|||||.|.:.|:..   .|..|..|...|:...: .:|..:...::|...|.::.
Mosquito    47 CGGSLIWENYVLTAAHCTADDNNAAPDVVRLGDINLDDDSDDKY-AQQLKIVEIIRHPEHRFSSR 110

  Fly   121 VNDIGLLRLYGEVTHYAHIRPICIILDHVVKSAPFERFEGFGWQQQGTEASSQVRQTVYLSQKKP 185
            .:|:.||||...||.:..:.|.|:..|..:   ||...|..||...|. |.:.:...|.||....
Mosquito   111 YHDLALLRLERNVTLHDTVAPGCLWNDEEI---PFPSMEATGWGSTGF-AKTPILLKVSLSLVPK 171

  Fly   186 FECHR------NGQLLPINEGQFCAGNRDRSFCRSNSGSPLTADFTYGVKNITVQVGLVSYGSEL 244
            ..|.:      .|....:.:.|.|||:.....|..:||.||........|.....:.:.|:|| :
Mosquito   172 STCDQQYRKGDRGLRQGLQDYQLCAGDIKMDTCPGDSGGPLQMKLLANAKMTPFIIAVTSFGS-V 235

  Fly   245 C--SPTSVYTDVVAFKDWI---------------------------------YNTVRNFE---TK 271
            |  |...||..|..:..||                                 |..:|.:|   ..
Mosquito   236 CGQSTPGVYMKVSPYIPWIRSELAKRGELIRGKITPKSLDPHSFLPYACALRYVHLREYEDDVVM 300

  Fly   272 GDQVVYEECRSNWAE-DVLVRLWEVSLH--------QNTFSGVLITNRFVLTVASAFPNIPLVMK 327
            |....:|...|..|. :::..:..|.||        .|.: ||:|....|:|:|    :...|.:
Mosquito   301 GKSATFESLDSTKAHMNIISSVQTVKLHYPAGTNGPDNCY-GVIIDEDTVVTLA----HCAAVQR 360

  Fly   328 VETKYLKS-----FDVESIHTHPRFTHSSMDNNIALLKLAHDVPNSDLVKPICIVPSPKL--PRM 385
            :...::..     .:|..:|.||::..:|.|||||||||.:....|....|.||....||  ||.
Mosquito   361 MTASHIADQNGTRNEVVKVHRHPQYRPNSYDNNIALLKLKNRYEFSRDFVPACIWSEFKLPDPRF 425

  Fly   386 LTT-----------LVDETTNDFRGVRNVTL---------NAINHIECARRIGKPLKSNQFC--- 427
            ..|           ..|....:||....|.|         |.....|..:.:...|.....|
Mosquito   426 YVTGQGRMDLNKFSYGDSPITEFREYLIVQLAPRADLQLSNCSFPDEYQKGLANGLTQEHLCFGN 490

  Fly   428 ----VAQPIDFKVQAPGSIIGTYRNIGDGNRYY--LFGLMSYSKD----GMVVYTYIQSYLDWI 481
                |.:....::.||     .:|.:....|::  ::.|..:.||    ...|.|.:..:.:|:
Mosquito   491 KPFLVPESCQMQIGAP-----LWRRVWRMERHFEHIYALNLFGKDCGFGRSAVATRLGYHHEWM 549

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	60/248 (24%)
		Tryp_SPc	46..261	CDD:214473	57/212 (27%)
		Tryp_SPc	293..484	CDD:304450	54/237 (23%)
		Tryp_SPc	293..481	CDD:214473	53/235 (23%)
AgaP_AGAP008403	XP_317049.4	Tryp_SPc	20..256	CDD:238113	59/214 (28%)
		Tryp_SPc	20..254	CDD:214473	57/212 (27%)
		Tryp_SPc	324..552	CDD:304450	54/236 (23%)
		CLIP	577..617	CDD:295450
		Tryp_SPc	656..872	CDD:304450
		Tryp_SPc	656..869	CDD:214473
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	156	1.000	Inparanoid score	I6716
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.960