DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and KLK8

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_653088.1	Gene:	KLK8 / 11202	HGNCID:	6369	Length:	305	Species:	Homo sapiens

Alignment Length:	230	Identity:	64/230 - (27%)
Similarity:	110/230 - (47%)	Gaps:	36/230 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PWMASIYKNNQFICDGTLVHKLFVLTAASCISKDSQLYVLFGMYN-QYRDASQFFNNEQYGVAVA 109
            ||.|::::..|.:|.|.||...:|||||.|  |..:..|..|.:: |.:|..:    ::..|..:
Human    90 PWQAALFQGQQLLCGGVLVGGNWVLTAAHC--KKPKYTVRLGDHSLQNKDGPE----QEIPVVQS 148

  Fly   110 LQH-----SNFRPNNGVNDIGLLRLYGEVTHYAHIRPICIILDHVVKSAPFERFEGFGWQQQGTE 169
            :.|     |:...:|  :|:.||:|..:.:..:.::||. :.||..:  |.::....||   ||.
Human   149 IPHPCYNSSDVEDHN--HDLMLLQLRDQASLGSKVKPIS-LADHCTQ--PGQKCTVSGW---GTV 205

  Fly   170 ASSQVR--QTVYLSQKKPFECHRNGQLLP--INEGQFCAG-NRDRSFCRSNSGSPLTADFTYGVK 229
            .|.:..  .|:..::.|.|...:.....|  |.:|..||| ::....|:.:||.||..|   |..
Human   206 TSPRENFPDTLNCAEVKIFPQKKCEDAYPGQITDGMVCAGSSKGADTCQGDSGGPLVCD---GAL 267

  Fly   230 NITVQVGLVSYGSELCSPT---SVYTDVVAFKDWI 261
            .     |:.|:||:.|..:   .|||::..:.|||
Human   268 Q-----GITSWGSDPCGRSDKPGVYTNICRYLDWI 297

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	64/230 (28%)
		Tryp_SPc	46..261	CDD:214473	62/228 (27%)
		Tryp_SPc	293..484	CDD:304450
		Tryp_SPc	293..481	CDD:214473
KLK8	NP_653088.1	Tryp_SPc	77..297	CDD:214473	62/228 (27%)
KLK8	NP_653088.1	Tryp_SPc	78..300	CDD:238113	64/230 (28%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910