DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and KLK11

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	XP_011524671.1	Gene:	KLK11 / 11012	HGNCID:	6359	Length:	307	Species:	Homo sapiens

Alignment Length:	330	Identity:	80/330 - (24%)
Similarity:	130/330 - (39%)	Gaps:	122/330 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly     3 RVLSLALIGLV--LCQGLAQLL---DKKCHDPKTSENINFNHGATETAPWMASIYKNNQFICDGT 62
            |:|.|.|:.|.  |..|..:::   :.|.|                :.||.|::::..:.:|..|
Human    34 RILQLILLALATGLVGGETRIIKGFECKPH----------------SQPWQAALFEKTRLLCGAT 82

  Fly    63 LVHKLFVLTAASC------------ISKD-----------SQLYVLFGMYN--------QYRDAS 96
            |:...::||||.|            :|.|           |:..|..|.:|        |.|.|:
Human    83 LIAPRWLLTAAHCLKPWVSLTSPTHVSPDLSSSNYCLSHLSRYIVHLGQHNLQKEEGCEQTRTAT 147

  Fly    97 QFFNNEQYGVAVALQHSNFRPN-NGVNDIGLLRLYGEVTHYAHIRPI------------CIILDH 148
            :.|.:..:        :|..|| :..|||.|:::...|:....:||:            |:|
Human   148 ESFPHPGF--------NNSLPNKDHRNDIMLVKMASPVSITWAVRPLTLSSRCVTAGTSCLI--- 201

  Fly   149 VVKSAPFERFEGFGWQQQGTEASSQVRQ---------TVYLSQKKPFECHRNGQLLPINEGQFCA 204
                        .||   |:.:|.|:|.         |:...||    | .|.....|.:...||
Human   202 ------------SGW---GSTSSPQLRLPHTLRCANITIIEHQK----C-ENAYPGNITDTMVCA 246

  Fly   205 ----GNRDRSFCRSNSGSPLTADFTYGVKNITVQVGLVSYGSELCSPT---SVYTDVVAFKDWIY 262
                |.:|.  |:.:||.||       |.|.::| |::|:|.:.|:.|   .|||.|..:.|||.
Human   247 SVQEGGKDS--CQGDSGGPL-------VCNQSLQ-GIISWGQDPCAITRKPGVYTKVCKYVDWIQ 301

  Fly   263 NTVRN 267
            .|::|
Human   302 ETMKN 306

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	69/277 (25%)
		Tryp_SPc	46..261	CDD:214473	67/274 (24%)
		Tryp_SPc	293..484	CDD:304450
		Tryp_SPc	293..481	CDD:214473
KLK11	XP_011524671.1	Tryp_SPc	53..300	CDD:214473	69/303 (23%)
KLK11	XP_011524671.1	Tryp_SPc	54..303	CDD:238113	71/305 (23%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910