DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG33465 and MASP2

DIOPT Version :9

Sequence 1:	NP_001033950.2	Gene:	CG33465 / 3885587	FlyBaseID:	FBgn0053465	Length:	488	Species:	Drosophila melanogaster
Sequence 2:	NP_006601.2	Gene:	MASP2 / 10747	HGNCID:	6902	Length:	686	Species:	Homo sapiens

Alignment Length:	263	Identity:	63/263 - (23%)
Similarity:	99/263 - (37%)	Gaps:	73/263 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    46 PWMASIYKNNQFICDGTLVHKLFVLTAASCISKDSQLYVLFGMYNQYRDASQF------------ 98
            ||...|....  ...|.|::..:|||||..:            |.|..|||..
Human   457 PWQVLILGGT--TAAGALLYDNWVLTAAHAV------------YEQKHDASALDIRMGTLKRLSP 507

  Fly    99 FNNEQYGVAVALQHSNFRPNNGV-NDIGLLRLYGEVTHYAHIRPICI---ILDHVVKSAPFERFE 159
            ...:.:..||.: |..:..:.|. |||.|::|..:|...::|.|||:   ..:..:::.......
Human   508 HYTQAWSEAVFI-HEGYTHDAGFDNDIALIKLNNKVVINSNITPICLPRKEAESFMRTDDIGTAS 571

  Fly   160 GFGWQQQGTEASSQVRQTVYLS-------------QKKPFECHRNGQLLPINEGQFCAG--NRDR 209
            |:|..|:|..|    |..:|:.             :|.|:.   .|.   :.....|||  :..:
Human   572 GWGLTQRGFLA----RNLMYVDIPIVDHQKCTAAYEKPPYP---RGS---VTANMLCAGLESGGK 626

  Fly   210 SFCRSNSGSPL------TADFTYGVKNITVQVGLVSYGSELCSPT---SVYTDVVAFKDWIYNTV 265
            ..||.:||..|      |..:..|        |:||:||..|...   .|||.|:.:..||.|.:
Human   627 DSCRGDSGGALVFLDSETERWFVG--------GIVSWGSMNCGEAGQYGVYTKVINYIPWIENII 683

  Fly   266 RNF 268
            .:|
Human   684 SDF 686

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG33465	NP_001033950.2	Tryp_SPc	46..264	CDD:238113	61/257 (24%)
		Tryp_SPc	46..261	CDD:214473	59/254 (23%)
		Tryp_SPc	293..484	CDD:304450
		Tryp_SPc	293..481	CDD:214473
MASP2	NP_006601.2	CUB	28..134	CDD:214483
		EGF_CA	138..176	CDD:214542
		CUB	184..293	CDD:278839
		CCP	300..361	CDD:214478
		Sushi	366..430	CDD:278512
		Tryp_SPc	444..679	CDD:214473	59/254 (23%)
		Tryp_SPc	445..682	CDD:238113	61/257 (24%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.910