DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG34041 and P4HA3

DIOPT Version :9

Sequence 1:	NP_001034077.5	Gene:	CG34041 / 3885583	FlyBaseID:	FBgn0054041	Length:	568	Species:	Drosophila melanogaster
Sequence 2:	NP_001275677.1	Gene:	P4HA3 / 283208	HGNCID:	30135	Length:	604	Species:	Homo sapiens

Alignment Length:	340	Identity:	79/340 - (23%)
Similarity:	144/340 - (42%)	Gaps:	54/340 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   262 SKVINILKIQENVVKYLENYIYALETKLKTIDEALIDLATYH---IQFERDKLAIASSPVASYSL 323
            :.|...|..:..::..|..|:...|.:|:       ||..::   :....|.....::|:.:::|
Human    35 TSVARALAPERRLLGLLRRYLRGEEARLR-------DLTRFYDKVLSLHEDSTTPVANPLLAFTL 92

  Fly   324 IHHMQSDWTHWQLFLQEDPGKDELASLM----SIKKYLPTKNDISEVCHGISKMLNAYLMTAQDI 384
            |..:||||.:....|:   ..:.:.:|.    .:::.||...|:......:.::.:.|::..:.:
Human    93 IKRLQSDWRNVVHSLE---ASENIRALKDGYEKVEQDLPAFEDLEGAARALMRLQDVYMLNVKGL 154

  Fly   385 ANGVILGTQTKYISSALKLEYLYMEIICNRHLMSLR--DCVALSDHSMEMKDYNKSKEWLNVAIS 447
            |.||.    .:...||:      .::...:.|.||.  ||..:...:.:|.||..:..||..|:|
Human   155 ARGVF----QRVTGSAI------TDLYSPKRLFSLTGDDCFQVGKVAYDMGDYYHAIPWLEEAVS 209

  Fly   448 MLESS-AYW--DPIVPSADLYLKLAEVYVKQQNWTLALE-TVEFALKS--NPRNAQLIRMQKRL- 505
            :...| ..|  :......|....||..|.:..|.:.||. :.||.|.|  |.|.|:.:...:||
Human   210 LFRGSYGEWKTEDEASLEDALDHLAFAYFRAGNVSCALSLSREFLLYSPDNKRMARNVLKYERLL 274

  Fly   506 ---SYHI----LLGPPKSPKLNIEN----------NDYRLRKNGSLYCFYDTKIRTFYSLLAPIK 553
               ..|:    ::..|..|.|...:          :...|.:..||||.|:|.... |.||.||:
Human   275 AESPNHVVAEAVIQRPNIPHLQTRDTYEGLCQTLGSQPTLYQIPSLYCSYETNSNA-YLLLQPIR 338

  Fly   554 AEVLFIDPLVILYHE 568
            .||:.::|.:.|||:
Human   339 KEVIHLEPYIALYHD 353

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG34041	NP_001034077.5	P4Ha_N	29..138	CDD:285528
		P4Ha_N	260..389	CDD:285528	24/133 (18%)
		TPR repeat	452..491	CDD:276809	12/42 (29%)
P4HA3	NP_001275677.1	P4Ha_N	58..159	CDD:285528	20/110 (18%)
		TPR_12	186..252	CDD:290160	16/65 (25%)
		P4Hc	356..>478	CDD:214780
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165149274
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG1591
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000199
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.740