Protein Alignment Octbeta3R and Htr1f

DIOPT Version :10

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_068629.2
• Gene: Htr1f / 60448
• RGDID: 71083
• Length: 366
• Species: Rattus norvegicus
• Alignment Length: 313
• Identity: 87/313 - (27%)
• Similarity: 143/313 - (45%)
• Gaps: 63/313 - (20%)

  Fly   140 LLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGG 204
            :|.....|.:.|.....|:|||.::...|||....||.:.|||:.|.|||:..|.|:. |.:...
  Rat    24 ILVSLTLSGLALMTTTINSLVITAIIVTRKLHHPANYLICSLAVTDFLVAVLVMPFSI-VYIVSE 87

  Fly   205 KWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPA 269
            .|:.|..:|:::.|:|:...:.|||||..|::|||.||...:||....|.:.....:..||::..
  Rat    88 SWIMGQGLCDLWLSVDIICCSCSILHLSAIALDRYRAITDAVEYARKRTPRHAGITITTVWVISV 152

  Fly   270 LISFTPIFLGWYTTEEHLREISLHPDQC----SFVVNKAYALISSSVSFWIPGIVMLVMYWRIFK 330
            .||..|:|  |    .|  :.:...|||    ..:|:..|   |:..:|:||.:::|::|::|::
  Rat   153 FISMPPLF--W----RH--QGNSRDDQCIIKHDHIVSTIY---STFGAFYIPLVLILILYYKIYR 206

  Fly   331 EA--IRQRKALSR-----TSSNILLNSVHMGHTQ-QPTSLSYLHPSDCDLNATSAREETHSALSN 387
            .|  :..::..||     .:..:||.|   |... :..|.||:
  Rat   207 AARTLYHKRQASRMIKEELNGQVLLES---GEKSIKLVSTSYM---------------------- 246

  Fly   388 LEDML-QPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDLEQERYEKVTHT 439
            ||..| .|:||.|....     .|.||      ||  :|:..:..|.:|::.|
  Rat   247 LEKSLSDPSTDFDRIHS-----TVKSP------RS--ELKHEKSWRRQKISGT 286

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	61/201 (30%)
		TM helix 1	142..167	CDD:320194	6/24 (25%)
		TM helix 2	174..200	CDD:320194	11/25 (44%)
		TM helix 3	213..243	CDD:320194	13/29 (45%)
		TM helix 4	255..278	CDD:320194	5/22 (23%)
		TM helix 5	302..331	CDD:320194	8/28 (29%)
		7tm_GPCRs	<1161..1234	CDD:475119
		TM helix 6	1167..1189	CDD:410628
		TM helix 7	1202..1227	CDD:410628
Htr1f	NP_068629.2	7tmA_5-HT1F	24..359	CDD:320456	87/313 (28%)
		TM helix 1	25..51	CDD:320456	7/25 (28%)
		TM helix 2	58..84	CDD:320456	12/26 (46%)
		TM helix 3	96..126	CDD:320456	13/29 (45%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	120..122		1/1 (100%)
		TM helix 4	138..160	CDD:320456	5/21 (24%)
		TM helix 5	178..207	CDD:320456	9/31 (29%)
		TM helix 6	286..316	CDD:320456	1/1 (100%)
		TM helix 7	326..351	CDD:320456
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	343..347