DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta3R and si:dkey-247m21.3

DIOPT Version :9

Sequence 1:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_017208337.2	Gene:	si:dkey-247m21.3 / 559089	ZFINID:	ZDB-GENE-091204-249	Length:	390	Species:	Danio rerio

Alignment Length:	279	Identity:	107/279 - (38%)
Similarity:	163/279 - (58%)	Gaps:	30/279 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   116 ANGSDIAVDNQAEL---EESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLR-VITNY 176
            |..||.|.|:..|:   ..|.:.||::|:      :||:...|||.||::::.::|:|| ..||:
Zfish     2 ATASDSAEDSVDEVVSKHTSRITLSIVLV------TIIIMTALGNLLVMVALCKDRQLRKKKTNF 60

  Fly   177 FVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYA 241
            |:||||.||:||||..|.. |::||:.|||.:|...|.|..||||..:||||||||||::|||||
Zfish    61 FIVSLAFADLLVALVVMPL-AAIELTTGKWNYGETFCLVRTSLDVLLTTASILHLCCIALDRYYA 124

  Fly   242 I-VRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYT--TEEHLREISLHPDQ---CSFV 300
            | .:||.|...||...|..||...|::|..|||.||...|.|  .|..:.:..|:..:   |.|:
Zfish   125 ICCQPLVYNNKMTPVRVSLMLVGCWVIPFFISFLPIMQSWNTIGIESFIEQRKLNSSRNSTCVFM 189

  Fly   301 VNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLSYL 365
            ||:.|||:.|:|:|::|.::|::.|.||:..|:...:.         :.|:|...: .|||   .
Zfish   190 VNQPYALVCSAVAFYVPLVLMVLAYQRIYVTAMGHARR---------IGSLHRAGS-APTS---T 241

  Fly   366 HPSDCDLNATSAREETHSA 384
            :|::....::..:.||.:|
Zfish   242 YPNNDQHGSSRIKNETKAA 260

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	88/206 (43%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	85/194 (44%)
si:dkey-247m21.3	XP_017208337.2	7tmA_5-HT4	23..325	CDD:320184	100/258 (39%)
		TM helix 1	24..50	CDD:320184	10/31 (32%)
		TM helix 2	58..84	CDD:320184	15/26 (58%)
		TM helix 3	96..126	CDD:320184	21/29 (72%)
		TM helix 4	139..162	CDD:320184	10/22 (45%)
		TM helix 5	191..220	CDD:320184	12/28 (43%)
		TM helix 6	254..284	CDD:320184	3/7 (43%)
		TM helix 7	293..318	CDD:320184
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328277at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	4	3.970