Protein Alignment Octbeta3R and 5-HT2B

DIOPT Version :9

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_001262373.1
• Gene: 5-HT2B / 41017
• FlyBaseID: FBgn0261929
• Length: 947
• Species: Drosophila melanogaster
• Alignment Length: 1242
• Identity: 258/1242 - (20%)
• Similarity: 401/1242 - (32%)
• Gaps: 513/1242 - (41%)

  Fly   108 STVGPNITANGSDIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRV 172
            :|....|:|...|:..|    ....|..|:|:|         :|....||.||.:::...|:|:.
  Fly    55 ATGNATISATFEDVPFD----ANNYWALLALVL---------VLGTAAGNILVCLAIAWERRLQN 106

  Fly   173 ITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVD 237
            :||||::|||:.|::||:..|.... :.|..|.:..|...|..:..|||.|.||||:|||.||||
  Fly   107 VTNYFLMSLAITDLMVAVLVMPLGI-LTLVKGYFPLGSEHCLTWICLDVLFCTASIMHLCTISVD 170

  Fly   238 RYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCSFVVN 302
            ||.::..|:.:..|.|.:.|...:..||:|...:|. |:.|.:  ::.|          .|.:||
  Fly   171 RYLSLRYPMRFGRNKTRRRVTLKIVFVWLLSIAMSL-PLSLMY--SKNH----------ASVLVN 222

  Fly   303 -------KAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRK----------------------- 337
                   ..|.|:.|.|.|:||..|||:.|....:...|||:
  Fly   223 GTCQIPDPVYKLVGSIVCFYIPLGVMLLTYCLTVRLLARQRQNLGGGQQTAAATPGWASGWLGQA 287

  Fly   338 -ALSR--TSSNIL------LNSVHMGHT--QQPTSLSYLHPSDCDLNATSAREETHSALS----- 386
             ||.|  |...:|      .:||...|:  ...|.||.|...:..|..:|.:|.|.:.::
  Fly   288 PALERRCTWRRLLKPGPGNASSVLHAHSANSTDTDLSTLDNHELWLPDSSIKEPTPTTMTALHQF 352

  Fly   387 ---------NLEDMLQPATDEDDDRDECD-----ELRVPSPPPRRLSRSSIDLRDLEQERYEKVT 437
                     .||.:...:|.....:.|..     :|:.||.|                :|| ..|
  Fly   353 GAEMLKLSRGLESVASSSTTGSPTKSEFSLSNHLQLQYPSSP----------------QRY-AAT 400

  Fly   438 HTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPNGPQ-QQLSLTSGS 501
            |           ||...||..|.||.|::.|...:|:              :|.. ..||.|:..
  Fly   401 H-----------QQSHHHNHQQHPAGVYHQQASPKGR--------------HGTTVLGLSTTTLG 440

  Fly   502 GNSEPEPESTAYRVFGGLNSDESEGNDLYDTHLPLAEDNKELKRLIEDNYLYFKRQTGGTIISGP 566
            ...|....|.|....||   ::|:|.               |.:|.:....|.||:...:.:  |
  Fly   441 IERESTRNSLASSRMGG---EQSDGT---------------LSQLSQRLRAYKKRRRASSAV--P 485

  Fly   567 GGGKYAALSETDFIRLKAGAAACGRKAFASSDSEFLRTISESRALPEQPVPGKEKGFNILSLLSK 631
            |..|.|...:.|                  .|.|
  Fly   486 GREKRAGHEDAD------------------EDVE------------------------------- 501

  Fly   632 TKRSSTECFTLEK-KRHQANSEGSSFFRRSRNRKLSHSYNGCGGGKERKLERRQRQ------HSD 689
                 |...||.: |||.:..:.:.:   .|:..:..|.:.....:|...:::.:|      |||
  Fly   502 -----TPTSTLRRHKRHNSLPKNALY---PRHTTVQESLDDDDDEEEESAQQKDQQTKSKICHSD 558

  Fly   690 TDSTPNKPDILLDINVLSEQSGASVIQQFSDGVQLIDFSELKTPPERIRSDDELAQLADC--FGE 752
            |:..|  |......::..:...:..:|                          |..:..|  ||:
  Fly   559 TELDP--PQKAKQCHIAGQNHQSDYLQ--------------------------LPSVCTCPYFGD 595

  Fly   753 SPQQ------------------PATPPPSLSPPELPEPSGLLIASSSELAEIFRSLSFPL-GRPA 798
            .|.|                  ..|...|.||.|:.    ||:.||.....:..|:|..: |.||
  Fly   596 RPLQNCVKSAEVKIISSAFRVTTTTTAVSSSPSEME----LLMCSSGNKKSLTSSVSAGITGGPA 656

  Fly   799 GAPQRLSTLSDQVCANYLMSPPNTPAPPAISVPNGGAMDSSASSNAQSASINVYFLSPPPHAAAP 863
            ||                       ||..:     |:..|..|::.|.:|:.|. .....:.|||
  Fly   657 GA-----------------------APATV-----GSTLSPHSAHNQGSSLTVQ-SDGSGYLAAP 692

  Fly   864 GYTPSDTSTVSLDVVTSLPMPVPVPQPNPQMASQSNISPKPEIILDSTLSPVEGCGDEHRDVTSP 928
            |                    .|.|
  Fly   693 G--------------------TPCP---------------------------------------- 697

  Fly   929 LFKRKDSAGDADVSVSGNGGAGGVGGVGGRQGRCSILAGYDGIQTVRKRQASVVTYDVNVINFSQ 993
                    |...:|:|                                :.|||||:|
  Fly   698 --------GRRKLSIS--------------------------------KTASVVTWD-------- 714

  Fly   994 ENSDSRSYIPMGRVSTSSAKHEFSNKSSLIRRGGICIFVDEEEAEIIEQRPRGITFAAVPSPLPK 1058
                             |::|                            |.||.:|..|.:.|..
  Fly   715 -----------------SSRH----------------------------RRRGSSFGGVRTSLLL 734

  Fly  1059 CPLCGADISSTTGTTANATATANADSTI----------------DTTVTTSSKRSIHEQTPDLGQ 1107
            .|       :.|.||:|::......:|:                .|..||||        |.:.|
  Fly   735 TP-------TKTATTSNSSTPLRRSATLRSHQNMNYQGAGECGGKTRTTTSS--------PCMLQ 784

  Fly  1108 RPASSSSSTRFWHKRTAAVTACWQQSKNRKRRFKTGCSHCGATGGSVRPAKGWKAEHKAARTLGI 1172
            |    ..:.|..|.|.::|.     |:|..|.           |..:|      .|.||.:.||:
  Fly   785 R----QQTVRSHHSRNSSVI-----SRNSSRH-----------GRIIR------LEQKATKVLGV 823

  Fly  1173 IMGVFLLCWLPFFLWYVITSLCGPACPCPDVL----VVVLFWIGYFNSTLNPLIYAYFNRDFREA 1233
            :...|::.|.|||:..::.::|   ..|.:.:    ..|:.|:||.:|.:||:.|..||:.||:|
  Fly   824 VFFTFVILWSPFFVLNLLPTVC---AECEERISHWVFDVVTWLGYASSMVNPIFYTIFNKVFRQA 885

  Fly  1234 FRNTLEC 1240
            |:..|.|
  Fly   886 FKKVLLC 892

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	71/232 (31%)
		7tm_1	156..>344	CDD:278431	70/220 (32%)
5-HT2B	NP_001262373.1	7tm_1	90..>262	CDD:278431	63/185 (34%)
		7tm_4	90..>238	CDD:304433	54/161 (34%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460675
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840