DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octbeta3R and mAChR-B

DIOPT Version :9

Sequence 1:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_649764.1	Gene:	mAChR-B / 40955	FlyBaseID:	FBgn0037546	Length:	1019	Species:	Drosophila melanogaster

Alignment Length:	1296	Identity:	265/1296 - (20%)
Similarity:	409/1296 - (31%)	Gaps:	476/1296 - (36%)

- Green bases have known domain annotations that are detailed below.

  Fly    63 SSLPITSQF-----VDASLTSLSLTATSSDASYSSPFSSYLSSDSTFELLSTVGPNITANGSDIA 122
            :|.|:..|.     .|.:.|:|.|...:..:...|..|. .||||  |:|..|.|...
  Fly    75 NSWPVNEQLQWYRNFDVNNTNLLLAVRNQSSDGGSTMSG-SSSDS--EILGPVLPPFA------- 129

  Fly   123 VDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVVSLAMADML 187
                         |...:|.....:..|:..|.||.||:::...:|.:|..:|||:.|||..|||
  Fly   130 -------------LWQTILIAICLAICIILTVGGNILVLLAFIVDRNIRQPSNYFIASLAATDML 181

  Fly   188 VALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNM 252
            :...:|.| .::.:..|.|..||.:|:::.|:|......|...:..|::|||.::....:|....
  Fly   182 IGTVSMPF-YTIYVLKGYWDLGPMLCDLWLSVDYTVCLVSQYTVLLITIDRYCSVKIAAKYRSWR 245

  Fly   253 THKTVCFMLANVWILPALISFTPIFLGWYTTEEHLR-EISLHPDQCS--FVVNKAY--ALISSSV 312
            |...|.:|:...||:|||:.|..|| ||    ||.. :..|.|.||:  |:.:..:  |||..
  Fly   246 TRTRVIYMVTITWIIPALLFFISIF-GW----EHFTGKRDLLPGQCAVQFLKDPIFNTALIIG-- 303

  Fly   313 SFWIPGIVMLVMYWRIFKEA--------IRQRKALSRTSSNILLNSVHMGHTQQPTSLSYLHPSD 369
            .:|...||:.|:|..|:|.|        .:|||..|..:.:....|...||.   ..:..:....
  Fly   304 YYWTTLIVLFVLYAGIYKTAYDMQKRSEAKQRKMQSMVALSAGAMSGMAGHA---AGIGVIEEKI 365

  Fly   370 CDLNATSAREET--HSALSNLEDMLQPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDLEQER 432
            .......|.::|  .||.:.:...|..:...:......:|:...:|..||.|.:.|.....::|.
  Fly   366 LKTKVELAGDQTDLDSACTTVIKRLSGSGQANPLAVATEEVEKMTPEQRRASAAKIQEEAKKREA 430

  Fly   433 YEKVTHTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPN-----GPQ 492
            ......::.:.|......::.|.||.|              ::|..::|:......:     |.|
  Fly   431 AVDAEKSERSSSPAFDSDEESSVNQAQ--------------QLITQQKLNNMRKRSSIGLVFGAQ 481

  Fly   493 QQLSLTSGSGNSEPEPESTAYRVFGGLNSDESEGNDLYDTHLPLAEDNKELKRLIEDNYLYFKRQ 557
            ..|..|.|.||.:   :||.       ||...|....|..|.....:...|:|
  Fly   482 AALLATRGKGNLQ---KSTT-------NSKSIEAMHQYHHHQQHHHNQSPLQR------------ 524

  Fly   558 TGGTIISGPGGGKYAALSETDFIRLKAGAAACGRKAFASSDSEFLRTISESRALPEQPVPGKEKG 622
                                                 |.|..|.
  Fly   525 -------------------------------------AQSKEEM--------------------- 531

  Fly   623 FNILSLLSKTKRSSTECFTLEKKRHQANSEGSSFFRRSRNRKLSHSYNGCGGGKERKLERRQRQH 687
                                                    |.|.|..|           ::|..|
  Fly   532 ----------------------------------------RSLHHHQN-----------QQQPHH 545

  Fly   688 SDTDSTPNKPDILLDINVLSEQSGASVIQQFSDGVQLIDFSELKTPPERIRSDDELAQL------ 746
            ....:.||.|   ||   ..:::..|.:.|.::..:|:|   |..||..:.:.|.|:.:
  Fly   546 QHHQNQPNPP---LD---RPKRTSCSTLSQIAEHDRLVD---LSAPPTLLNTSDPLSPVDLAPIE 601

  Fly   747 --ADCFGESPQQPATPPPS-------LSPPELPEPSGLLIASSSELAEIFRSLSFPLGRPAGAPQ 802
              :|...:...|...|||.       ||......|.|    :||..:|:..:.............
  Fly   602 VPSDQVHQGLVQTILPPPDAFQCPTPLSDDYSDRPFG----NSSGNSELALTYDLMTNSELRYMD 662

  Fly   803 RLSTLSDQVCANYLMSPPNT---------PAPPAISVPNGGAMDSSAS-------SNAQSASIN- 850
            ..|.:...|.||...||.::         |.|||...|....::.|.|       |.:||.|:|
  Fly   663 ESSAMLASVTANSTTSPNDSVQGKPPVLPPPPPARRNPPKSNLNQSLSQTPSQNQSPSQSLSLNL 727

  Fly   851 -------------------------------------------VYFLSPP-------PHAAAPGY 865
                                                       :..|..|       ||..|.
  Fly   728 NPNHNQSQSQSIEEAVAIEKRLLVSYTGIEDFAKVRRESCIEAICLLDVPGKLAADCPHRRAS-- 790

  Fly   866 TPSDTSTVSLDVVTSLPMPVPVPQPNPQMASQSNISPKPEIILDSTLSPVEGCGDEHRDVTSPL- 929
            :|.:||  |.|.:...||| |:|           :|||.:.....|.:|....|     ||.|:
  Fly   791 SPMETS--SKDAILYSPMP-PMP-----------LSPKVKTSTPQTGTPQSAAG-----VTPPVP 836

  Fly   930 ------FKRKDSAGDADVSVSG-NGGAGGVGGVGGRQGRCSILAGYDGIQTVRKRQASVVTYDVN 987
                  .:..||..:...|.|| ....||||| ||.|         ||:...:|....   .|.|
  Fly   837 LERIEERETSDSNTNKMPSTSGTTSSTGGVGG-GGEQ---------DGVGATKKNAGD---DDAN 888

  Fly   988 VINFS---QENSDSRSYIPMGRVSTSSAKHEFSNKSSLIRRGGICIFVDEEEAEIIEQRPRGITF 1049
            ....|   ..||..|::|      .|..|| |.:|.:|
  Fly   889 REEKSLAASRNSSKRAFI------HSIGKH-FKSKKAL--------------------------- 919

  Fly  1050 AAVPSPLPKCPLCGADISSTTGTTANATATANADSTIDTTVTTSSKRSIHEQTPDLGQRPASSSS 1114
                 ||    :.|                                         :|.|..|
  Fly   920 -----PL----ILG-----------------------------------------VGGRQKS--- 931

  Fly  1115 STRFWHKRTAAVTACWQQSKNRKRRFKTGCSHCGATGGSVRPAKGWKAEHKAARTLGIIMGVFLL 1179
                             :|:||.|                          ||.||:..|:|.|:.
  Fly   932 -----------------KSENRAR--------------------------KAFRTISFILGCFVA 953

  Fly  1180 CWLPFFLWYVITSLC-GPACPCPDVLVVVLFWIGYFNSTLNPLIYAYFNRDFREAFRNTLE 1239
            ||.|:.:..::...| .|.| ..:.|.:..:::.|.||.:||..||..|:.|::.|...|:
  Fly   954 CWTPYHVLALVEGFCRHPPC-INEHLYMFSYFLCYANSPMNPFCYALANQQFKKTFTRILK 1013

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	67/212 (32%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	65/200 (33%)
mAChR-B	NP_649764.1	7tm_1	150..>341	CDD:278431	65/198 (33%)
mAChR-B	NP_649764.1	7tm_4	150..>336	CDD:304433	62/193 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460689
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	2	1.840