Protein Alignment Octbeta3R and 5-HT2A

DIOPT Version :10

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_730859.1
• Gene: 5-HT2A / 40575
• FlyBaseID: FBgn0087012
• Length: 930
• Species: Drosophila melanogaster
• Alignment Length: 1194
• Identity: 224/1194 - (18%)
• Similarity: 333/1194 - (27%)
• Gaps: 581/1194 - (48%)

  Fly    57 TTTTPTSSLPITSQFVDASLTSLSLTATSSDASYSSPFSSYLSSDSTFELLSTVGPNITANGSDI 121
            |.|:....||        :||:|:.|:|:|.|..::.|:
  Fly   242 TNTSLDMFLP--------NLTALNTTSTASTADMATEFA-------------------------- 272

  Fly   122 AVDNQAELEESWLDLS-------LLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVV 179
                   :.:|:||.|       .|.:..|||     |..|||.||.::|..:|||:.:||||:.
  Fly   273 -------VTKSFLDYSPHGYDFLFLFVVFFIF-----AGGLGNILVCLAVALDRKLQNVTNYFLF 325

  Fly   180 SLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVR 244
            |||:||:||:|..|...| :....|.|..|...||:|.:.||...::||||:|.||:.||..|..
  Fly   326 SLAIADLLVSLFVMPMGA-IPAFLGYWPLGFTWCNIYVTCDVLACSSSILHMCFISLGRYMGIRN 389

  Fly   245 PLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCSFVVNKAYALIS 309
            ||......|.:.....:|.||::..::|.:...||....:..:.|    |:.| .:.|:|:.:..
  Fly   390 PLGSRHRSTKRLTGIKIAIVWVMAMMVSSSITVLGLVNEKNIMPE----PNIC-VINNRAFFVFG 449

  Fly   310 SSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLSYLHPSDCDLNA 374
            |.|:|:|| ::|:|..:.:....:|::                                     |
  Fly   450 SLVAFYIP-MLMMVTTYALTIPLLRKK-------------------------------------A 476

  Fly   375 TSAREETHSALSNLEDMLQPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDLEQERYEKVTHT 439
            ..|.|...|.|.                             |||. ....||
  Fly   477 RFAAEHPESELF-----------------------------RRLG-GRFTLR------------- 498

  Fly   440 DSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPNGPQQQLSLTSGSGNS 504
                         |.|:|                     ::|....|......:.||:..|:.|.
  Fly   499 -------------PQHSQ---------------------QQLQMFSSFSGSNNKFLSMGDGNRNF 529

  Fly   505 EPEPESTAYRVFGGLNSDESEGNDLYDTHLPLAEDNKELKRLIEDNYLYFKRQTGGTIISGPGGG 569
            ..|.|...    ||..|..|   .:.....||.:......|.:  ..:.|:....||
  Fly   530 NTEGEMEE----GGAPSRRS---GVEPAERPLMQQRTASSRSM--GTVSFRNVVNGT-------- 577

  Fly   570 KYAALSETDFIRLKAGAAACGRKAFASSDSEFLRTISESRALPEQPVPGKEKGFNILSLLSKTKR 634
                          :|||..||:...::.|.|
  Fly   578 --------------SGAAGSGRRTTGTAHSSF--------------------------------- 595

  Fly   635 SSTECFTLEKKRHQANSEGSSFFRRSRNRKLSHSYNGCGGGKERKLERRQRQHSDTDSTPNKPDI 699
                           ...|:..||.|
  Fly   596 ---------------RFSGAGIFRHS--------------------------------------- 606

  Fly   700 LLDINVLSEQSGASVIQQFSDGVQLIDFSELKTPPERIRSDDELAQLADCFGESPQQPATPPPSL 764
                                                                           |.
  Fly   607 ---------------------------------------------------------------SS 608

  Fly   765 SPPELPEPSGLLIASSSELAEIFRSLSFPLGRPAGAPQRLSTLSDQVCANYLMS--PPNTPAPPA 827
            ||           |||.......||.|| ..:..|.|    .|.|::..:..:|  ||:
  Fly   609 SP-----------ASSCHSTSTSRSSSF-WRKHGGYP----NLMDRLAIHLRLSLVPPS------ 651

  Fly   828 ISVPNGGAMDSSASSNAQSASINVYFLSPPPHAAAPGYTPSDTSTVSLDVVTSLPMPVPVPQPNP 892
             |.||            :.||:.|                    |:|                .|
  Fly   652 -SHPN------------RRASVRV--------------------TIS----------------QP 667

  Fly   893 QMASQSNISPKPEIILDSTLSPVEGCGDEHRDVTSPLFKRKDSAGDADVSVSGNGGAGGVGGVGG 957
            |:...:|                                                    |||.||
  Fly   668 QLGYPTN----------------------------------------------------VGGNGG 680

  Fly   958 RQ-GRCSILAGYDGIQTVRKRQASVVTYDVNVINFSQENSDSRSYIPMGRVSTSSAKHEFSNKSS 1021
            |. |...:.||.:|...                               ||.|.||.
  Fly   681 RTVGATEVGAGGNGSSA-------------------------------GRTSNSSL--------- 705

  Fly  1022 LIRRGGICIFVDEEEAEIIEQRPRGITFAAVPSPLPKCPLCGADISSTTGTTANATATANADSTI 1086
                ||..:.                                 .|::..|...|.:..|..:..:
  Fly   706 ----GGTSLM---------------------------------KIATIQGPILNQSQAAGGNHMV 733

  Fly  1087 DTTVTTSSKRSIHEQTPDLGQRPASSSSSTRFWHKRTAAVTACWQQSKNRKRRFKTGCSHCGATG 1151
            .....|:.|       |:..||  :.....:|...|.|..|...:...||.:|
  Fly   734 QKVKPTALK-------PEEPQR--NKVRPFKFAFNRVATPTLNLRFLNNRSKR------------ 777

  Fly  1152 GSVRPAKGWKAEHKAARTLGIIMGVFLLCWLPFFLWYVITSLCGPACPCPDVLVVVLFWIGYFNS 1216
             :...|.....|.||.:.||::...|:|||.|||:..:|.:.| |.|..|:.:|....|:||.:|
  Fly   778 -NSLSANAVATEQKATKVLGLVFFTFVLCWSPFFILNIIFAAC-PECQVPEHVVNTCLWLGYVSS 840

  Fly  1217 TLNPLIYAYFNRDFREAFRNTLEC 1240
            |:||:||..|||.||.||...|:|
  Fly   841 TINPIIYTIFNRTFRAAFIRLLKC 864

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	67/195 (34%)
		TM helix 1	142..167	CDD:320194	10/24 (42%)
		TM helix 2	174..200	CDD:320194	14/25 (56%)
		TM helix 3	213..243	CDD:320194	14/29 (48%)
		TM helix 4	255..278	CDD:320194	4/22 (18%)
		TM helix 5	302..331	CDD:320194	9/28 (32%)
		7tm_GPCRs	<1161..1234	CDD:475119	32/72 (44%)
		TM helix 6	1167..1189	CDD:410628	9/21 (43%)
		TM helix 7	1202..1227	CDD:410628	10/24 (42%)
5-HT2A	NP_730859.1	7tm_GPCRs	298..>473	CDD:475119	63/181 (35%)
		TM helix 2	321..343	CDD:410628	12/21 (57%)
		TM helix 3	359..381	CDD:410628	10/21 (48%)
		TM helix 4	404..420	CDD:410628	4/15 (27%)
		TM helix 5	443..466	CDD:410628	8/23 (35%)
		7tm_GPCRs	<779..858	CDD:475119	33/79 (42%)
		TM helix 6	792..814	CDD:410628	9/21 (43%)
		TM helix 7	826..851	CDD:410628	10/24 (42%)