Protein Alignment Octbeta3R and mAChR-A

DIOPT Version :10

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_523844.2
• Gene: mAChR-A / 37892
• FlyBaseID: FBgn0000037
• Length: 805
• Species: Drosophila melanogaster
• Alignment Length: 1257
• Identity: 245/1257 - (19%)
• Similarity: 380/1257 - (30%)
• Gaps: 530/1257 - (42%)

  Fly    37 ASHLQPATLTGHISTTAAAKTTTTPTSSLPITSQFVDASLTSLSLTATSSDASYSSPFSSYLSSD 101
            |:|..|:.|.....|...:.||||.|              |:.:.|.|:|.|.||..:..
  Fly    10 AAHGPPSILEPLFKTVTTSTTTTTTT--------------TTSTTTTTASPAGYSPGYPG----- 55

  Fly   102 STFELLSTVGPNITANGSDIAVD-------NQA------ELEESWLDLSLLLLKGFIFSSIILAA 153
              ..||:.:..|:|:..:....|       ||.      |.:.....|:.:::.||:.:.:....
  Fly    56 --TTLLTALFENLTSTAASGLYDPYSGMYGNQTNGTIGFETKGPRYSLASMVVMGFVAAILSTVT 118

  Fly   154 VLGNALVIISVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNS 218
            |.||.:|:||.:.:::|:.|:|||:.|||:||..:...:|...|...:. |.|..||.:|:.:.:
  Fly   119 VAGNVMVMISFKIDKQLQTISNYFLFSLAIADFAIGAISMPLFAVTTIL-GYWPLGPIVCDTWLA 182

  Fly   219 LDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTT 283
            ||...|.||:|:|..||.|||:::.|||.|....|......|:...|.: :|:.:.|....|...
  Fly   183 LDYLASNASVLNLLIISFDRYFSVTRPLTYRAKRTTNRAAVMIGAAWGI-SLLLWPPWIYSWPYI 246

  Fly   284 EEHLREISLHPDQC--SFVVNKAYALISSSV-SFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSN 345
            |   .:.::..|:|  .|:....|....::: :|:.|..:|..:||||::|..:::|.|
  Fly   247 E---GKRTVPKDECYIQFIETNQYITFGTALAAFYFPVTIMCFLYWRIWRETKKRQKDL------ 302

  Fly   346 ILLNSVHMGHTQQPTSLSYLHPSDCDLNATSAREETHSALSNLEDMLQPATDEDDDRDECDELRV 410
                                                                             
  Fly   303 ----------------------------------------------------------------- 302

  Fly   411 PSPPPRRLSRSSIDLRDLEQERYEKVTHTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKM 475
                                            |::.|                         ||.
  Fly   303 --------------------------------PNLQA-------------------------GKK 310

  Fly   476 IPSKELDKEHSHPNGPQQQLSLTSGSGNSEPEPESTAYRVFGGLNSDESEGNDLYDT-HLPLAED 539
            ..||.                     .||..| .:......|||.:....|.:.:|| ..|.:|.
  Fly   311 DSSKR---------------------SNSSDE-NTVVNHASGGLLAFAQVGGNDHDTWRRPRSES 353

  Fly   540 NKELKRLIEDNYLYFKRQTGGTIISGPGG--GKYAALSETDFIRLKAGAAACGRKAFASSDSEFL 602
            :.:    .|..|:     |...|.||..|  .:.:::..|:.|
  Fly   354 SPD----AESVYM-----TNMVIDSGYHGMHSRKSSIKSTNTI---------------------- 387

  Fly   603 RTISESRALPEQPVPGKEKGFNILSLLSKTKRSSTECFTLEKK-----RHQANSEGSSFFRRSRN 662
                                          |:|.| ||...|:     .|....:...|
  Fly   388 ------------------------------KKSYT-CFGSIKEWCIAWWHSGREDSDDF------ 415

  Fly   663 RKLSHSYNGCGGGKERKLERRQRQHSD-------TDSTPNKPDI--LLDINVLSE--QSGASVIQ 716
                 :|             .|.:.||       |..||.:..:  ...:||:.:  ..|.||
  Fly   416 -----AY-------------EQEEPSDLGYATPVTIETPLQSSVSRCTSMNVMRDNYSMGGSV-- 460

  Fly   717 QFSDGVQLIDFSELKTPPERIRSDDELAQLADCFGESPQQPATPPPSLSPPELPEPSGLLIASSS 781
               .||:         ||..:.||                       :||..||.|.   :||.|
  Fly   461 ---SGVR---------PPSILLSD-----------------------VSPTPLPRPP---LASIS 487

  Fly   782 ELAEIFRSLSFPLGRPAGAPQRLSTLSDQVCANYLMSPPNTPAPPAISVPNGGAMDSSASSNAQS 846
            :|                  |.:|.::....||.     ||..       ||    :.|.:|..:
  Fly   488 QL------------------QEMSAVTASTTANV-----NTSG-------NG----NGAINNNNN 518

  Fly   847 ASINVYFLSPPPHAAAPGYTPSDTSTVSLDVV------TSLPMPVPVPQPNPQMASQSNISPKPE 905
            ||.|       .:.|..|....:.|.:.|...      .|..:|| :.:.|.:..||
  Fly   519 ASHN-------GNGAVNGNGAGNGSGIGLGTTGNATHRDSRTLPV-INRINSRSVSQ-------- 567

  Fly   906 IILDSTLSPVEGCGDEHRDVTSPLFKRKDSAGDADVSVSGNGGAGGVGGVG----GRQGRC--SI 964
                              |....:..|..|.|.:..:.:|.||..|.|...    ..||.|  ||
  Fly   568 ------------------DSVYTILIRLPSDGASSNAANGGGGGPGAGAAASASLSMQGDCAPSI 614

  Fly   965 -LAGYDGIQTVRKRQASVVTYDVNVINFSQENSDSRSYIPMGRVSTSSAKHEFSNKSSLIRRGGI 1028
             :...||..|.   .|:..............:.||...:|:|| ..|.|:|
  Fly   615 KMIHEDGPTTT---AAAAPLASAAATRRPLPSRDSEFSLPLGR-RMSHAQH-------------- 661

  Fly  1029 CIFVDEEEAEIIEQRPRGITFAAVPSPLPKCPLCGADISSTTGTTANATATANADSTIDTTVTTS 1093
                   :|.::..:       .:|..|.|     |...:..|....|.|..||
  Fly   662 -------DARLLNAK-------VIPKQLGK-----AGGGAAGGGVGGAHALMNA----------- 696

  Fly  1094 SKRSIHEQTPDLGQRPASSSSSTRFWHKRTAAVTACWQQSKNRKRRFKTGCSHCGATGGSVRPAK 1158
                                        |.||       .|.:|.:.|
  Fly   697 ----------------------------RNAA-------KKKKKSQEK----------------- 709

  Fly  1159 GWKAEHKAARTLGIIMGVFLLCWLPFFLWYVITSLCGPACPCPDVLVVVLFW-----IGYFNSTL 1218
              :.|.|||:||..|:..|::.|.|    |.|..|..|...|.|.:...| |     :.|.|||:
  Fly   710 --RQESKAAKTLSAILLSFIITWTP----YNILVLIKPLTTCSDCIPTEL-WDFFYALCYINSTI 767

  Fly  1219 NPLIYAYFNRDFREAFRNTLEC 1240
            ||:.||..|..||..:...|.|
  Fly   768 NPMCYALCNATFRRTYVRILTC 789

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	60/198 (30%)
		TM helix 1	142..167	CDD:320194	8/24 (33%)
		TM helix 2	174..200	CDD:320194	10/25 (40%)
		TM helix 3	213..243	CDD:320194	13/29 (45%)
		TM helix 4	255..278	CDD:320194	4/22 (18%)
		TM helix 5	302..331	CDD:320194	8/29 (28%)
		7tm_GPCRs	<1161..1234	CDD:475119	29/77 (38%)
		TM helix 6	1167..1189	CDD:410628	7/21 (33%)
		TM helix 7	1202..1227	CDD:410628	11/29 (38%)
mAChR-A	NP_523844.2	7tmA_mAChR_DM1-like	105..>300	CDD:320428	60/199 (30%)
		TM helix 1	106..132	CDD:320428	8/25 (32%)
		TM helix 2	139..165	CDD:320428	10/25 (40%)
		TM helix 3	177..207	CDD:320428	13/29 (45%)
		TM helix 4	219..242	CDD:320428	4/23 (17%)
		TM helix 5	265..294	CDD:320428	8/28 (29%)
		7tm_GPCRs	<707..783	CDD:475119	30/99 (30%)
		TM helix 6	716..738	CDD:410628	9/25 (36%)
		TM helix 7	751..776	CDD:410628	10/25 (40%)