Protein Alignment Octbeta3R and 5-HT1A

DIOPT Version :10

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_001356890.1
• Gene: 5-HT1A / 37196
• FlyBaseID: FBgn0004168
• Length: 846
• Species: Drosophila melanogaster
• Alignment Length: 1269
• Identity: 244/1269 - (19%)
• Similarity: 387/1269 - (30%)
• Gaps: 556/1269 - (43%)

  Fly     2 SGVNVADLLA------------TTMTLPITAAAGAATSQAAATSATNASHLQPATLTGHISTTAA 54
            ||...||.:.            ||.|...:..|.||.:.|||:::..|:..:......|.:.|..
  Fly    76 SGKRRADFIGSLALKPPPTDVNTTTTTAGSPLATAALAAAAASASVAAAAARITAKAAHRALTTK 140

  Fly    55 AKTTTTPTSSLPITSQFVD-------------ASLTSLSLTATSSDASYSSPFSSYLSSDS-TFE 105
            ...|::|.||..:  |.:|             |.|.:.:|....:|   ||.|...|::.| ..:
  Fly   141 QDATSSPASSPAL--QLIDMDNNYTNVAVGLGAMLLNDTLLLEGND---SSLFGEMLANRSGQLD 200

  Fly   106 LLS-TVGPNITANGSDIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRK 169
            |:: |.|.|:|.  |.:|       |:.:..|..:.:...:...:||..::||..||.::...|.
  Fly   201 LINGTGGLNVTT--SKVA-------EDDFTQLLRMAVTSVLLGLMILVTIIGNVFVIAAIILERN 256

  Fly   170 LRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCI 234
            |:.:.||.|.|||:||:.||...|...|..|:|.| |:.||.:|:::.|.||...|||||||..|
  Fly   257 LQNVANYLVASLAVADLFVACLVMPLGAVYEISQG-WILGPELCDIWTSCDVLCCTASILHLVAI 320

  Fly   235 SVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCSF 299
            :||||:|:.. ::|..:.|...|..|:..||....::|..|.| || ...::|:.|  ...:|..
  Fly   321 AVDRYWAVTN-IDYIHSRTSNRVFMMIFCVWTAAVIVSLAPQF-GW-KDPDYLQRI--EQQKCMV 380

  Fly   300 VVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLSY 364
            ..:.:|.:.::..:|::|.:|:|.:||:|::
  Fly   381 SQDVSYQVFATCCTFYVPLLVILALYWKIYQ---------------------------------- 411

  Fly   365 LHPSDCDLNATSAREETHSALSNLEDMLQPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDLE 429
                       :||:..|                                 ||
  Fly   412 -----------TARKRIH---------------------------------RR------------ 420

  Fly   430 QERYEKVTHTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPNGPQQQ 494
                                                                             
  Fly   421 ----------------------------------------------------------------- 420

  Fly   495 LSLTSGSGNSEPEPESTAYRVFGGLNSDESEGNDLYDTHLPLAEDNKELKRLIEDNYLYFKRQTG 559
                      .|.|...|      :|:::.:|....||.|       ...||....:...|.:||
  Fly   421 ----------RPRPVDAA------VNNNQPDGGAATDTKL-------HRLRLRLGRFSTAKSKTG 462

  Fly   560 GTI-ISGP-GGGKYAAL---SETDFIRLKAGAAACGRKAFASSDSEFLRTISESRALPEQPVPGK 619
            ..: :||| .||:...|   :.|:.:......      .|:||:.:     |:|||..|.|
  Fly   463 SAVGVSGPASGGRALGLVDGNSTNTVNTVEDT------EFSSSNVD-----SKSRAGVEAP---- 512

  Fly   620 EKGFNILSLLSKTKRSSTECFTLEKKRHQANSEGSSFFRRSRNRKLSHSYNGCGGGKERKLERRQ 684
                         ..|..:..|:......|..:|.|      ..|.|.:.||......::.:.::
  Fly   513 -------------STSGNQIATVSHLVALAKQQGKS------TAKSSAAVNGMAPSGRQEDDGQR 558

  Fly   685 RQHSDTDSTPNKPDILLDINVLSEQSGASVIQQFSDGVQLIDFSELKTPPERIRSDDELAQLADC 749
            .:|.:.:                                  |..||:...|::
  Fly   559 PEHGEQE----------------------------------DREELEDQDEQV------------ 577

  Fly   750 FGESPQQPATPPPSLSPPELPEPSGLLIASSSELAEIFRSLSFPLGRPAGAPQRLSTLSDQVCAN 814
               .| ||.|...:::.....|......|:..|:.|              .|| |....:||  .
  Fly   578 ---GP-QPTTATSAMTAAGTNESEDQCKANGVEVLE--------------DPQ-LQQQLEQV--Q 621

  Fly   815 YLMSPPNTPAPPAISVPNGGAMDSSASSNAQSASINVYFLSPPPHAAAPGYTPSDTSTVSLDVVT 879
            .|..          ||.:||...:|.|:.....||:.  |||        .||           |
  Fly   622 QLQK----------SVKSGGGGGASTSNATTITSISA--LSP--------QTP-----------T 655

  Fly   880 SLPMPVPVPQPNPQMASQSNISPKPEIILDSTLSPVEGCGDEHRDVTSPLFKRKDSAGDADVSVS 944
            |..:.:......|..|..|.::               .|...|
  Fly   656 SQGVGIAAAAAGPMTAKTSTLT---------------SCNQSH---------------------- 683

  Fly   945 GNGGAGGVGGVGGRQGRCSILAGYDGIQTVRKRQASVVTYDVNVINFSQENSDSRSYIPMGRVST 1009
                                                                             
  Fly   684 ----------------------------------------------------------------- 683

  Fly  1010 SSAKHEFSNKSSLIRRGGICIFVDEEEAEIIEQRPRGITFAAVPSPLPKCPLCGADISSTTGTTA 1074
                                                              ||||         ||
  Fly   684 --------------------------------------------------PLCG---------TA 689

  Fly  1075 NATATANADSTIDTTVTTSSKRSIHEQTPDLGQRPASSSSSTRFWHKRTAAVTACWQQSKNRKRR 1139
            |.:.            :|...||....||.  |:|...:...:...::.:::....|:...||..
  Fly   690 NESP------------STPEPRSRQPTTPQ--QQPHQQAHQQQQQQQQLSSIANPMQKVNKRKET 740

  Fly  1140 FKTGCSHCGATGGSVRPAKGWKAEHKAARTLGIIMGVFLLCWLPFFLWYVITSLCGPACPCPDVL 1204
            .:.                  |.|.|||:||.||.|.|::||||||:..:...||. ||...|.:
  Fly   741 LEA------------------KRERKAAKTLAIITGAFVVCWLPFFVMALTMPLCA-ACQISDSV 786

  Fly  1205 VVVLFWIGYFNSTLNPLIYAYFNRDFREAFRNTL 1238
            ..:..|:|||||||||:||..|:.:||:||:..|
  Fly   787 ASLFLWLGYFNSTLNPVIYTIFSPEFRQAFKRIL 820

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	65/195 (33%)
		TM helix 1	142..167	CDD:320194	6/24 (25%)
		TM helix 2	174..200	CDD:320194	12/25 (48%)
		TM helix 3	213..243	CDD:320194	17/29 (59%)
		TM helix 4	255..278	CDD:320194	6/22 (27%)
		TM helix 5	302..331	CDD:320194	8/28 (29%)
		7tm_GPCRs	<1161..1234	CDD:475119	37/72 (51%)
		TM helix 6	1167..1189	CDD:410628	13/21 (62%)
		TM helix 7	1202..1227	CDD:410628	13/24 (54%)
5-HT1A	NP_001356890.1	7tmA_5-HT1A_invertebrates	227..>413	CDD:320454	65/236 (28%)
		TM helix 1	228..254	CDD:320454	6/25 (24%)
		TM helix 2	261..287	CDD:320454	12/25 (48%)
		TM helix 3	299..329	CDD:320454	17/29 (59%)
		TM helix 4	340..362	CDD:320454	6/21 (29%)
		TM helix 5	383..412	CDD:320454	8/73 (11%)
		7tm_GPCRs	<743..816	CDD:475119	37/91 (41%)
		TM helix 6	750..772	CDD:410628	13/21 (62%)
		TM helix 7	784..809	CDD:410628	13/24 (54%)