DRSC/TRiP Functional Genomics Resources

powered by:
logo

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits


Protein Alignment Octbeta3R and 5-HT1B

DIOPT Version :10

Sequence 1:NP_001034048.2 Gene:Octbeta3R / 3885573 FlyBaseID:FBgn0250910 Length:1256 Species:Drosophila melanogaster
Sequence 2:NP_001137708.2 Gene:5-HT1B / 37191 FlyBaseID:FBgn0263116 Length:629 Species:Drosophila melanogaster


Alignment Length:1195 Identity:213/1195 - (17%)
Similarity:330/1195 - (27%) Gaps:611/1195 - (51%)


- Green bases have known domain annotations that are detailed below.


  Fly    60 TPTSSLPITSQFVDASLTSLSLTATSSDASYSSPFSSYLSS--DSTFELLSTV-GPNITANGS-- 119
            |.|:::......|.||:..:.|.|...:.|.....:..|:.  |:|..|...| ..:|..||:  
  Fly     4 TVTTAMAAGDDDVPASILEIELPAILLNESLFIELNGNLTQLVDTTSNLSQIVWNRSINGNGNSN 68

  Fly   120 --DIAVDNQAELE-ESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVVSL 181
              |:..|.|.... |.|| |..::....:...:||..::||..||.::...|.|:.:.||.|.||
  Fly    69 TFDLVDDEQERAAVEFWL-LVKMIAMAVVLGLMILVTIIGNVFVIAAIILERNLQNVANYLVASL 132

  Fly   182 AMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPL 246
            |:||:.||...|...|..|:|.| |:.||.:|:::.|.||...|||||||..|:.|||:.:.. :
  Fly   133 AVADLFVACLVMPLGAVYEISNG-WILGPELCDIWTSCDVLCCTASILHLVAIAADRYWTVTN-I 195

  Fly   247 EYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCSFVVNKAYALISSS 311
            :|....|.:.|..|:..||....::|..|.| || ...::::.|  ....|....:..|.:.::.
  Fly   196 DYNNLRTPRRVFLMIFCVWFAALIVSLAPQF-GW-KDPDYMKRI--EEQHCMVSQDVGYQIFATC 256

  Fly   312 VSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLSYLHPSDCDLNATS 376
            .:|::|.:|:|.:||:|:..|.::.:..::.|.|:.|..                 :|||     
  Fly   257 CTFYVPLLVILFLYWKIYIIARKRIQRRAQKSFNVTLTE-----------------TDCD----- 299

  Fly   377 AREETHSALSNLEDMLQPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDLEQERYEKVTHTDS 441
                  ||:                                                        
  Fly   300 ------SAV-------------------------------------------------------- 302

  Fly   442 APSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPNGPQQQLSLTSGSGNSEP 506
                                                 :||.||.|                    
  Fly   303 -------------------------------------RELKKERS-------------------- 310

  Fly   507 EPESTAYRVFGGLNSDESEGNDLYDTHLPLAEDNKELKRLIEDNYLYFKRQTGGTIISGPGGGKY 571
                                                 ||..|..                     
  Fly   311 -------------------------------------KRRAERK--------------------- 317

  Fly   572 AALSETDFIRLKAGAAACGRKAFASSDSEFLRTISESRALPEQPVPGKEKGFNILSLLSKTKRSS 636
                     ||:||.                ||          ||.|                  
  Fly   318 ---------RLEAGE----------------RT----------PVDG------------------ 329

  Fly   637 TECFTLEKKRHQANSEGSSFFRRSRNRKLSHSYNGCGGGKERKLERRQR----QHSDTDSTPNKP 697
                                             :|.||..:|:..:|.|    ::::|       
  Fly   330 ---------------------------------DGTGGQLQRRTRKRMRICFGRNTNT------- 354

  Fly   698 DILLDINVLSEQSGASVIQQFSDGVQLIDFSELKTPPERIRSDDELAQLADCFGESPQQPATPPP 762
                 .||::...||..   .|.....:||:.|..    .|.:.|.                   
  Fly   355 -----ANVVAGSEGAVA---RSMAAIAVDFASLAI----TREETEF------------------- 388

  Fly   763 SLSPPELPEPSGLLIASSSELAEIFRSLSFPLGRPAGAPQRLSTLSDQVC----ANYLMSPPNTP 823
            |.|..:....:|..:.:.|..|:.:|:.:         ...:.|||.||.    .:.:.|..|..
  Fly   389 STSNYDNKSHAGTELTTVSSDADDYRTSN---------ANEIITLSQQVAHATQHHLIASHLNAI 444

  Fly   824 APPAISVPNGGAMDSSASSNAQSASINVYFLSPPPHAAAPGYTPSDTSTVSLDVVTSLPMPVPVP 888
            .|.|.|:..||.                                                     
  Fly   445 TPLAQSIAMGGV----------------------------------------------------- 456

  Fly   889 QPNPQMASQSNISPKPEIILDSTLSPVEGCGDEHRDVTSPLFKRKDSAGDADVSVSGNGGAGGVG 953
                                        ||    ...|:|..|....||....:|:|..|:|   
  Fly   457 ----------------------------GC----LTTTTPSEKALSGAGTVAGAVAGGSGSG--- 486

  Fly   954 GVGGRQGRCSILAGYDGIQTVRKRQASVVTYDVNVINFSQENSDSRSYIPMGRVSTSSAKHEFSN 1018
              .|.:|     ||.:|                                                
  Fly   487 --SGEEG-----AGTEG------------------------------------------------ 496

  Fly  1019 KSSLIRRGGICIFVDEEEAEIIEQRPRGITFAAVPSPLPKCPLCGADISSTTGTTANATATANAD 1083
            |::.:..||:                    .|::.:|                            
  Fly   497 KNAGVGLGGV--------------------LASIANP---------------------------- 513

  Fly  1084 STIDTTVTTSSKRSIHEQTPDLGQRPASSSSSTRFWHKRTAAVTACWQQSKNRKRRFKTGCSHCG 1148
                                                |::.|            |||         
  Fly   514 ------------------------------------HQKLA------------KRR--------- 521

  Fly  1149 ATGGSVRPAKGWKAEHKAARTLGIIMGVFLLCWLPFFLWYVITSLCGPACPCPDVLVVVLFWIGY 1213
                .:..|   |.|.|||:||.||.|.|::||||||:..:..||| ..|.....:..:..|:||
  Fly   522 ----QLLEA---KRERKAAQTLAIITGAFVICWLPFFVMALTMSLC-KECEIHTAVASLFLWLGY 578

  Fly  1214 FNSTLNPLIYAYFNRDFREAFRNTL 1238
            |||||||:||..||.:||.||:..|
  Fly   579 FNSTLNPVIYTIFNPEFRRAFKRIL 603

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Octbeta3RNP_001034048.2 7tmA_DmOct-betaAR-like 142..>338 CDD:320194 63/195 (32%)
TM helix 1 142..167 CDD:320194 6/24 (25%)
TM helix 2 174..200 CDD:320194 12/25 (48%)
TM helix 3 213..243 CDD:320194 15/29 (52%)
TM helix 4 255..278 CDD:320194 6/22 (27%)
TM helix 5 302..331 CDD:320194 8/28 (29%)
7tm_GPCRs <1161..1234 CDD:475119 37/72 (51%)
TM helix 6 1167..1189 CDD:410628 13/21 (62%)
TM helix 7 1202..1227 CDD:410628 12/24 (50%)
5-HT1BNP_001137708.2 TM helix 1 92..118 CDD:320454 6/25 (24%)
TM helix 2 125..151 CDD:320454 12/25 (48%)
TM helix 3 163..193 CDD:320454 15/29 (52%)
TM helix 4 204..226 CDD:320454 6/21 (29%)
TM helix 5 247..276 CDD:320454 8/28 (29%)
7tm_GPCRs <525..599 CDD:475119 38/77 (49%)
TM helix 6 533..555 CDD:410628 13/21 (62%)
TM helix 7 567..592 CDD:410628 12/24 (50%)
7tmA_5-HT1A_invertebrates 91..>287 CDD:320454 63/201 (31%)

Return to query results.
Submit another query.