Protein Alignment Octbeta3R and HTR1B

DIOPT Version :10

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_000854.1
• Gene: HTR1B / 3351
• HGNCID: 5287
• Length: 390
• Species: Homo sapiens
• Alignment Length: 259
• Identity: 82/259 - (31%)
• Similarity: 129/259 - (49%)
• Gaps: 23/259 - (8%)

  Fly   112 PNITANGSDIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNY 176
            |:...:..|....:...|  .|..|.::||     :.|.||..|.||.||.:|.|.|||....||
Human    29 PSQNCSAKDYIYQDSISL--PWKVLLVMLL-----ALITLATTLSNAFVIATVYRTRKLHTPANY 86

  Fly   177 FVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYA 241
            .:.|||:.|:||::..|..:....:: |:|..|..:|:.:.|.|:...||||||||.|::|||:|
Human    87 LIASLAVTDLLVSILVMPISTMYTVT-GRWTLGQVVCDFWLSSDITCCTASILHLCVIALDRYWA 150

  Fly   242 IVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCSFVVNKAYA 306
            |...:||....|.|....|:|.||:....||..|.|......||.:.|..::.|..      .|.
Human   151 ITDAVEYSAKRTPKRAAVMIALVWVFSISISLPPFFWRQAKAEEEVSECVVNTDHI------LYT 209

  Fly   307 LISSSVSFWIPGIVMLVMYWRIFKEA----IRQ---RKALSRTSSNILLNSVHMGHTQQPTSLS 363
            :.|:..:|:.|.::::.:|.||:.||    ::|   |.....|.:.::.:|  .|.|...||::
Human   210 VYSTVGAFYFPTLLLIALYGRIYVEARSRILKQTPNRTGKRLTRAQLITDS--PGSTSSVTSIN 271

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	69/202 (34%)
		TM helix 1	142..167	CDD:320194	9/24 (38%)
		TM helix 2	174..200	CDD:320194	9/25 (36%)
		TM helix 3	213..243	CDD:320194	16/29 (55%)
		TM helix 4	255..278	CDD:320194	8/22 (36%)
		TM helix 5	302..331	CDD:320194	7/28 (25%)
		7tm_GPCRs	<1161..1234	CDD:475119
		TM helix 6	1167..1189	CDD:410628
		TM helix 7	1202..1227	CDD:410628
HTR1B	NP_000854.1	7tmA_5-HT1B_1D	46..380	CDD:320455	80/242 (33%)
		TM helix 1	51..77	CDD:320455	12/30 (40%)
		TM helix 2	84..110	CDD:320455	9/25 (36%)
		TM helix 3	122..152	CDD:320455	16/29 (55%)
		DRY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	146..148		1/1 (100%)
		TM helix 4	164..187	CDD:320455	8/22 (36%)
		TM helix 5	205..234	CDD:320455	7/34 (21%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	259..281		5/15 (33%)
		TM helix 6	307..337	CDD:320455
		TM helix 7	348..373	CDD:320455
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	365..369