Protein Alignment Octbeta3R and HTR1A

DIOPT Version :10

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_000515.2
• Gene: HTR1A / 3350
• HGNCID: 5286
• Length: 422
• Species: Homo sapiens
• Alignment Length: 244
• Identity: 80/244 - (32%)
• Similarity: 131/244 - (53%)
• Gaps: 26/244 - (10%)

  Fly    99 SSDSTFELLSTVGPNITANGSDIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIIS 163
            |..:.||    .|.| |...||:.|..|             ::...:..::|..||||||.|:.:
Human    14 SPPAPFE----TGGN-TTGISDVTVSYQ-------------VITSLLLGTLIFCAVLGNACVVAA 60

  Fly   164 VQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASI 228
            :...|.|:.:.||.:.|||:.|::|::..:...|..::. .||..|...|:::.:|||...|:||
Human    61 IALERSLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVL-NKWTLGQVTCDLFIALDVLCCTSSI 124

  Fly   229 LHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLH 293
            ||||.|::|||:||..|::|....|.:....:::..|::..|||..|: |||.|.|:.     ..
Human   125 LHLCAIALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPM-LGWRTPEDR-----SD 183

  Fly   294 PDQCSFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEA-IRQRKALSR 341
            ||.|:...:..|.:.|:..:|:||.::|||:|.|||:.| .|.||.:.:
Human   184 PDACTISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKK 232

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	69/196 (35%)
		TM helix 1	142..167	CDD:320194	8/24 (33%)
		TM helix 2	174..200	CDD:320194	8/25 (32%)
		TM helix 3	213..243	CDD:320194	16/29 (55%)
		TM helix 4	255..278	CDD:320194	5/22 (23%)
		TM helix 5	302..331	CDD:320194	12/28 (43%)
		7tm_GPCRs	<1161..1234	CDD:475119
		TM helix 6	1167..1189	CDD:410628
		TM helix 7	1202..1227	CDD:410628
HTR1A	NP_000515.2	Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1..23		3/12 (25%)
		7tmA_5-HT1A_vertebrates	37..411	CDD:320453	70/203 (34%)
		TM helix 1	38..64	CDD:320453	8/25 (32%)
		TM helix 2	71..97	CDD:320453	8/25 (32%)
		TM helix 3	109..139	CDD:320453	16/29 (55%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	133..135		1/1 (100%)
		TM helix 4	151..173	CDD:320453	5/22 (23%)
		TM helix 5	192..221	CDD:320453	12/28 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	235..262
		TM helix 6	338..368	CDD:320453
		TM helix 7	379..404	CDD:320453
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	396..400