Protein Alignment Octbeta3R and Dop2R

DIOPT Version :9

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_001014758.2
• Gene: Dop2R / 33007
• FlyBaseID: FBgn0053517
• Length: 905
• Species: Drosophila melanogaster
• Alignment Length: 1275
• Identity: 235/1275 - (18%)
• Similarity: 366/1275 - (28%)
• Gaps: 644/1275 - (50%)

  Fly     1 MSGVNVADLLATTMTLPITAAAGAATSQAAATSATNASHLQPATLTGHISTTAAAKTTTTPTSSL 65
            :.|...|:||..|.|:   |........|.:|::.:........:.|.::.||.........|.
  Fly   235 LGGFGDAELLQRTATV---ARETLGNRTAPSTTSYDGGGSGDVGVAGGLAGTAGGGVGGAGGSG- 295

  Fly    66 PITSQFVDASLTSLSLTATSSDASYSSPFSSYLSSDSTFELLSTVGPNITANGSDIAVDNQAELE 130
                    .|...|.|      .:::..|.:|  :.||....||:.|.:...||.   .:...||
  Fly   296 --------GSTFMLLL------ENFNDYFPNY--NGSTVSGTSTIAPGVAITGSR---GSGLLLE 341

  Fly   131 ESWLDLSLLLLKGFIFSS-------------------------IILAAVL---GNALVIISVQRN 167
            :   :|:.|.|.|:..:.                         :||..:|   ||.|||:||.|.
  Fly   342 Q---NLTGLYLDGYRLNCTNETLNLTDSCGELRVVDHNYWALILILFPILTLFGNILVILSVCRE 403

  Fly   168 RKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLC 232
            |.|:.:||||:||||:||:|||:..|.| |...|..|.|.....:|:.|.::||..||:||.:|.
  Fly   404 RSLQTVTNYFIVSLAIADLLVAVVVMPF-AVYFLVNGAWALPDVVCDFYIAMDVICSTSSIFNLV 467

  Fly   233 CISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQC 297
            .||:|||.|:.:|::|..:...:.||..:..||.:.|.|. :||.||...|..  ||    ||.|
  Fly   468 AISIDRYIAVTQPIKYAKHKNSRRVCLTILLVWAISAAIG-SPIVLGLNNTPN--RE----PDVC 525

  Fly   298 SFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSL 362
            :| .|..:.|.||..||:||.|:|:.:||.||| |:|.|....|.:....|:.:..|
  Fly   526 AF-YNADFILYSSLSSFYIPCIIMVFLYWNIFK-ALRSRARKQRAARKPHLSELTGG-------- 580

  Fly   363 SYLHPSDCDLNATSAREETHSALSNLEDMLQPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRD 427
                                   |.:|::.|                     .|||:.:::|
  Fly   581 -----------------------SVIENIAQ---------------------TRRLAETALD--- 598

  Fly   428 LEQERYEKVTHTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPNGPQ 492
              ..|:                                      ..:::|
  Fly   599 --SSRH--------------------------------------ASRILP--------------- 608

  Fly   493 QQLSLTSGSGNSEPEPESTAYRVFGGLNSDESEGNDLYDTHLPLAEDNKELKRLIEDNYLYFKRQ 557
            .:.:..:.||::|.|.|:..             ..|:.|.|:           ::.|
  Fly   609 DEAATNTASGSNEEEDENAI-------------SPDIDDCHV-----------IVND-------- 641

  Fly   558 TGGTIISGPGGGKYAALSETDFIRLKAGAAACGRKAFASSDSEFLRTISESRALPEQPVPGKEKG 622
                             ..|:|:                     |.|:.|            |.|
  Fly   642 -----------------KSTEFM---------------------LATVVE------------ETG 656

  Fly   623 FNILSLLSKTKRSSTECFTLEKKRHQANSEGSSFFRRSRNRKLSHSYNGCGGGKERKLERRQRQH 687
            .::::.:           |.:.:...|:..|:                                |
  Fly   657 NSVVAQI-----------TTQPQLVVADPNGN--------------------------------H 678

  Fly   688 SDTDSTPNKPDILLDINVLSEQSGASVIQQFSDGVQLIDFSELKTPPERIRSDDELAQLADCFGE 752
            ....:..|..|:|..:...|..:..|
  Fly   679 DSGYAASNVDDVLAGVAPASASAATS--------------------------------------- 704

  Fly   753 SPQQPATPPPSLSPPELPEPSGLLIASSSELAEIFRSLSFPLGRPAG--APQRLSTLSDQVCANY 815
                 |.|..|.|||:.|.|||..:..||..::         .||.|  :|:|
  Fly   705 -----AAPRSSGSPPDSPLPSGATLQRSSVSSQ---------RRPTGDDSPKR------------ 743

  Fly   816 LMSPPNTPAPPAISVPNGGAMDSSASSNAQSASINVYFLSPPPHAAAPGYTPSDTSTVSLDVVTS 880
                 ..||..::.|.|
  Fly   744 -----GEPALRSVGVDN------------------------------------------------ 755

  Fly   881 LPMPVPVPQPNPQMASQSNISPKPEIILDSTLSPVEGCGDEHRDVTSPLFKRKDSAGDADVSVSG 945
                             |:::.||
  Fly   756 -----------------SSVAMKP----------------------------------------- 762

  Fly   946 NGGAGGVGGVGGRQGRCSILAGYDGIQTVRKRQASVVTYDVNVINFSQENSDSRSYIPMGRVSTS 1010
                                             .|.|.|.|      ||
  Fly   763 ---------------------------------LSFVRYGV------QE---------------- 772

  Fly  1011 SAKHEFSNKSSLIRRGGICIFVDEEEAEIIEQRPRGITFAAVPSPLPKCPLCGADISSTTGTTAN 1075
                                                                             
  Fly   773 ----------------------------------------------------------------- 772

  Fly  1076 ATATANADSTIDTTVTTSSKRSIHEQTPDLGQRPASSSSSTRFW----HKRTAAVTACWQQSKNR 1136
            |...|..|||:.||..|||::.            ..:|.::||.    ||            .::
  Fly   773 AMTLARNDSTLSTTSKTSSRKD------------KKNSQASRFTIYKVHK------------ASK 813

  Fly  1137 KRRFKTGCSHCGATGGSVRPAKGWKAEHKAARTLGIIMGVFLLCWLPFFLWYVITSLCGP-ACPC 1200
            |:|.|:..                |.|.||.:||.|::||||.||||||...::.::|.. ...|
  Fly   814 KKREKSSA----------------KKERKATKTLAIVLGVFLFCWLPFFSCNIMDAMCAKFKKDC 862

  Fly  1201 PDVLVVVLF--WIGYFNSTLNPLIYAYFNRDFREAFRNTL 1238
            ...|...:.  |:||.||.:||:||..||.:||:||:..:
  Fly   863 RPGLTAYMMTTWLGYINSFVNPVIYTIFNPEFRKAFKKIM 902

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	85/227 (37%)
		7tm_1	156..>344	CDD:278431	82/187 (44%)
Dop2R	NP_001014758.2	7tmA_D2-like_dopamine_R	376..>565	CDD:320181	84/198 (42%)
		TM helix 1	377..403	CDD:320181	10/25 (40%)
		TM helix 2	410..436	CDD:320181	16/26 (62%)
		TM helix 3	448..478	CDD:320181	15/29 (52%)
		TM helix 4	490..513	CDD:320181	8/23 (35%)
		TM helix 5	529..558	CDD:320181	15/29 (52%)
		7tm_GPCRs	<822..898	CDD:333717	33/75 (44%)
		TM helix 6	825..850	CDD:320095	15/24 (63%)
		TM helix 7	866..891	CDD:320095	10/24 (42%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45460673
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	P	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.940