DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octbeta3R and HRH2

DIOPT Version :9

Sequence 1:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001354640.1	Gene:	HRH2 / 3274	HGNCID:	5183	Length:	422	Species:	Homo sapiens

Alignment Length:	458	Identity:	124/458 - (27%)
Similarity:	196/458 - (42%)	Gaps:	96/458 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 VGPNITANGSDIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVIT 174
            :.||.||  |...:|:.|      ..:::.:    :.:.:||..|.||.:|.::|..||:||.:|
Human     1 MAPNGTA--SSFCLDSTA------CKITITV----VLAVLILITVAGNVVVCLAVGLNRRLRNLT 53

  Fly   175 NYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRY 239
            |.|:||||:.|:|:.|..:.|:|..:|| .||.||...||:|.||||...|||||:|..||:|||
Human    54 NCFIVSLAITDLLLGLLVLPFSAIYQLS-CKWSFGKVFCNIYTSLDVMLCTASILNLFMISLDRY 117

  Fly   240 YAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEE-----HLREISLHPDQCSF 299
            .|::.||.||:.:|...|...|..:|::...:||..|.|||.:..|     |.      ..:|..
Human   118 CAVMDPLRYPVLVTPVRVAISLVLIWVISITLSFLSIHLGWNSRNETSKGNHT------TSKCKV 176

  Fly   300 VVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSS-----------NILLNSVHM 353
            .||:.|.|:...|:|::|.::|.:.|:||||.|..|.|.::..||           .:.|.:| |
Human   177 QVNEVYGLVDGLVTFYLPLLIMCITYYRIFKVARDQAKRINHISSWKAATIREHKATVTLAAV-M 240

  Fly   354 GH---TQQPTSLSYLHPSDCDLNATSAREETHSAL--------SNLEDMLQPATDEDDDRDECDE 407
            |.   ...|...::::..   |....|..|...|:        |.|..:|..|.:.|
Human   241 GAFIICWFPYFTAFVYRG---LRGDDAINEVLEAIVLWLGYANSALNPILYAALNRD-------- 294

  Fly   408 LRVPSPPPRRLSRSSIDLRDLEQERYEKVTHTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTE 472
                    .|.....:....|......|.:...:|..:...|.::|...:.:|    ...|:|:.
Human   295 --------FRTGYQQLFCCRLANRNSHKTSLRSNASQLSRTQSREPRQQEEKP----LKLQVWSG 347

  Fly   473 GKM-IPSKELDKE-------------------------HSHPNGPQQQLSLTSGSGNSEPEPEST 511
            .:: .|....|::                         ..|..||.::||....|...:..|...
Human   348 TEVTAPQGATDRKPALSCTTCSSNLLSCCKSLWGLRFLQRHMGGPSEELSGEPLSEEPQKRPPQK 412

  Fly   512 AYR 514
            |.|
Human   413 AVR 415

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	83/215 (39%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	78/192 (41%)
HRH2	NP_001354640.1	7tmA_Histamine_H2R	19..299	CDD:320179	98/310 (32%)
		TM helix 1	21..45	CDD:320179	7/27 (26%)
		TM helix 2	54..76	CDD:320179	10/21 (48%)
		TM helix 3	92..114	CDD:320179	13/21 (62%)
		TM helix 4	137..153	CDD:320179	4/15 (27%)
		TM helix 5	180..203	CDD:320179	6/22 (27%)
		TM helix 6	233..255	CDD:320179	5/22 (23%)
		TM helix 7	267..292	CDD:320179	6/24 (25%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	316..340		4/27 (15%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40613
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	3	2.870