Protein Alignment Octbeta3R and ser-3

DIOPT Version :10

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_491954.1
• Gene: ser-3 / 259744
• WormBaseID: WBGene00004778
• Length: 610
• Species: Caenorhabditis elegans
• Alignment Length: 1202
• Identity: 197/1202 - (16%)
• Similarity: 303/1202 - (25%)
• Gaps: 661/1202 - (54%)

  Fly    44 TLTGHI----STTAAAKTTTTPTSSLPITSQFVDASLTSLSLTATSSDASYSSPFSSYLSSDSTF 104
            ||.|..    |...:..||||.....|||.:..:.|....|  ...|.|.:             |
 Worm     7 TLNGQFIAENSDFLSENTTTTTLGFTPITEESPNCSFYEWS--RNPSHAQF-------------F 56

  Fly   105 ELLSTVGPNITANGSDIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRK 169
            .:.|.:.                                 :.:.:::..||||||||.:|...|:
 Worm    57 RIFSIIS---------------------------------VLTVLVVVVVLGNALVIAAVLLRRR 88

  Fly   170 LRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCI 234
            ||..|...::|||:||:||....:.|:.:.|:....|:||...|.::.:||::..||||.:|..|
 Worm    89 LRSATGLLILSLALADLLVGTVILPFSIANEVLDQYWIFGETWCTIWLTLDIWMCTASIYNLVAI 153

  Fly   235 SVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCSF 299
            |:|||.||::||.||:.:|.......:|.|||...||.....||.....::..      |.:|:.
 Worm   154 SIDRYIAIIKPLNYPMLVTKFRARCTVAIVWIGSFLICSPSFFLASSIKDKET------PCRCTP 212

  Fly   300 V-VNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLS 363
            . ..:.|.:.|:|.||:||.|:::.:|:||:   :..|.|.....|.::..:......|.|.|..
 Worm   213 ANAGRVYVVFSASSSFYIPMIIVVFVYFRIY---VAARAATKSIYSGMMSVTAAANKKQNPKSYL 274

  Fly   364 YLHPSDCDLNATSAREETHSALSNLEDMLQPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDL 428
            ..||                                      |.:...|.|..|:.|.|
 Worm   275 LNHP--------------------------------------DVINKDSLPMLRVHRGS------ 295

  Fly   429 EQERYEKVTHTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPNGPQQ 493
                           |::|         |:.|..|
 Worm   296 ---------------SVVA---------QITPNKP------------------------------ 306

  Fly   494 QLSLTSGSGNSEPEPESTAYRVFGGLNSDESEGNDLYDTHLPLAEDNKELKRLIEDNYLYFKRQT 558
                                                |:|                      .||.
 Worm   307 ------------------------------------YNT----------------------CRQN 313

  Fly   559 GGTIISGPGGGKYAALSETDFIRLKAGAAACGRKAFASSDSEFLRTISESRALPEQPVPGKEKGF 623
            |.:|.:...|..            :..|||...:.||:..::.|.......|..:.|:..:
 Worm   314 GNSIDATANGTS------------QITAAATKARKFANDSAKTLVNRGAVGATQQAPIGAR---- 362

  Fly   624 NILSLLSKTKRSSTECFTLEKKRHQANSEGSSFFRRSRNRKLSHSYNGCGGGKERKLERRQRQHS 688
                                .|||..:||.|           ..|.||.               :
 Worm   363 --------------------FKRHGRDSESS-----------VDSMNGT---------------N 381

  Fly   689 DTDSTPNKPDILLDINVLSEQSGASVIQQFSDGVQLIDFSELKTPPERIRSDDELAQLADCFGES 753
            ...:||:|             ||                            ::||
 Worm   382 SYSATPHK-------------SG----------------------------NEEL---------- 395

  Fly   754 PQQPATPPPSLSPPELPEPSGLLIASSSELAEIFRSLSFPLGRPAGAPQRLSTLSDQVCANYLMS 818
                                                                             
 Worm   396 ----------------------------------------------------------------- 395

  Fly   819 PPNTPAPPAISVPNGGAMDSSASSNAQSASINVYFLSPPPHAAAPGYTPSDTSTVSLDVVTSLPM 883
                          |..:::|.||:..|
 Worm   396 --------------GSLIENSRSSSTDS------------------------------------- 409

  Fly   884 PVPVPQPNPQMASQSNISPKPEIILDSTLSPVEGCGDEHRDVTSPLFKRKDSAGDADVSVSGNGG 948
                                                   .:.|..|..:.|.
 Worm   410 ---------------------------------------NEKTEQLTNQTDD------------- 422

  Fly   949 AGGVGGVGGRQGRCSILAGYDGIQTVRKRQASVVTYDVNVINFSQENSDSRSYIPMGRVSTSSAK 1013
                                                     |||..|:::..
 Worm   423 -----------------------------------------NFSMSNNNNNG------------- 433

  Fly  1014 HEFSNKSSLIRRGGICIFVDEEEAEIIEQRPRGITFAAVPSPLPKCPLCGADISSTTGTTANATA 1078
                               ||:||
 Worm   434 -------------------DEKEA----------------------------------------- 438

  Fly  1079 TANADSTIDTTVTTSSKRSIHEQTPDLGQRPASSSSSTRFWHKRTAAVTACWQQSKNRKRRFKTG 1143
                   .|.::.:.||:.             |.|.:::|.|          ...:.:|:|
 Worm   439 -------FDESLLSESKKK-------------SKSLASKFNH----------LMRRGQKKR---- 469

  Fly  1144 CSHCGATGGSVRPAKGWKAEHKAARTLGIIMGVFLLCWLPFFLWYVITSLCGPACPCPDVLVVVL 1208
                  |.|:..  |....|.|||:|:.|:.|.|:.|||.|.|.|      |......||:..::
 Worm   470 ------TAGAYE--KRLSLEIKAAKTVAIVTGCFIFCWLGFALVY------GLEIKLNDVVWSIV 520

  Fly  1209 FWIGYFNSTLNPLIYAYFNRDFREAFRNTLEC 1240
            ||:||.||.|||:||..|||:||..|:..|.|
 Worm   521 FWLGYLNSALNPVIYTVFNREFRICFKRLLTC 552

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	67/196 (34%)
		TM helix 1	142..167	CDD:320194	9/24 (38%)
		TM helix 2	174..200	CDD:320194	9/25 (36%)
		TM helix 3	213..243	CDD:320194	14/29 (48%)
		TM helix 4	255..278	CDD:320194	6/22 (27%)
		TM helix 5	302..331	CDD:320194	11/28 (39%)
		7tm_GPCRs	<1161..1234	CDD:475119	33/72 (46%)
		TM helix 6	1167..1189	CDD:410628	10/21 (48%)
		TM helix 7	1202..1227	CDD:410628	13/24 (54%)
ser-3	NP_491954.1	7tmA_Octopamine_R	80..>252	CDD:320191	61/180 (34%)
		TM helix 2	93..119	CDD:320191	9/25 (36%)
		TM helix 3	132..162	CDD:320191	14/29 (48%)
		TM helix 4	174..197	CDD:320191	6/22 (27%)
		TM helix 5	216..245	CDD:320191	11/31 (35%)
		7tm_GPCRs	<479..546	CDD:475119	33/72 (46%)
		TM helix 6	485..507	CDD:410628	11/27 (41%)
		TM helix 7	514..539	CDD:410628	13/24 (54%)