DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta3R and Htr4

DIOPT Version :9

Sequence 1:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_036985.2	Gene:	Htr4 / 25324	RGDID:	2850	Length:	388	Species:	Rattus norvegicus

Alignment Length:	273	Identity:	108/273 - (39%)
Similarity:	150/273 - (54%)	Gaps:	40/273 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly   134 LDLSLLLLKGF----------IFSSIILAAVLGNALVIISVQRNRKLRVI-TNYFVVSLAMADML 187
            ||.::...:||          .|:.:||.|:|||.||:::|.|:|:||.| ||||:||||.||:|
  Rat     4 LDANVSSNEGFGSVEKVVLLTFFAMVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADLL 68

  Fly   188 VALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAI-VRPLEYPLN 251
            |::..|.|.| :||....|.:|...|.|..||||..:||||.||||||:|||||| .:||.|...
  Rat    69 VSVLVMPFGA-IELVQDIWFYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRNK 132

  Fly   252 MTHKTVCFMLANVWILPALISFTPIFLGWY------TTEEHLREISLHPDQCSFVVNKAYALISS 310
            ||...:..||...|::|..|||.||..||.      ..|:.....:.:...|.|:|||.||:..|
  Rat   133 MTPLRIALMLGGCWVIPMFISFLPIMQGWNNIGIVDVIEKRKFNHNSNSTFCVFMVNKPYAITCS 197

  Fly   311 SVSFWIPGIVMLVMYWRIF---KEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLSYLHPSDCDL 372
            .|:|:||.::|::.|:||:   ||..:|.:.|.|..:               ||.|  .|...|.
  Rat   198 VVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGA---------------TSES--RPQTADQ 245

  Fly   373 NAT-SAREETHSA 384
            ::| ..|.||.:|
  Rat   246 HSTHRMRTETKAA 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	94/210 (45%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	89/198 (45%)
Htr4	NP_036985.2	7tmA_5-HT4	20..323	CDD:320184	104/257 (40%)
		TM helix 1	22..46	CDD:320184	10/23 (43%)
		TM helix 2	56..78	CDD:320184	13/21 (62%)
		TM helix 3	94..116	CDD:320184	14/21 (67%)
		TM helix 4	140..156	CDD:320184	7/15 (47%)
		TM helix 5	190..213	CDD:320184	9/22 (41%)
		TM helix 6	258..280	CDD:320184	1/1 (100%)
		TM helix 7	291..316	CDD:320184
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328277at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44908
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	4	3.970