DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta3R and Adrb2

DIOPT Version :9

Sequence 1:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_036624.2	Gene:	Adrb2 / 24176	RGDID:	2060	Length:	418	Species:	Rattus norvegicus

Alignment Length:	296	Identity:	104/296 - (35%)
Similarity:	154/296 - (52%)	Gaps:	33/296 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   100 SDSTFELLSTVGPN-ITANGSDIAVDNQAELEESW-LDLSLLLLKGFIFSSIILAAVLGNALVII 162
            :||.|.|    .|| ..|.|.||.    .|.:|:| :.:::|:      |.|:||.|.||.|||.
  Rat     6 NDSDFLL----APNGSRAPGHDIT----QERDEAWVVGMAILM------SVIVLAIVFGNVLVIT 56

  Fly   163 SVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTAS 227
            ::.:..:|:.:||||:.|||.||:::.|..:.|.|| .:....|.||.|.|..:.|:||...|||
  Rat    57 AIAKFERLQTVTNYFITSLACADLVMGLAVVPFGAS-HILMKMWNFGNFWCEFWTSIDVLCVTAS 120

  Fly   228 ILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISL 292
            |..||.|:||||.||..|.:|...:|......::..|||:..|.||.||.:.||.. .|.:.|..
  Rat   121 IETLCVIAVDRYVAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRA-THKQAIDC 184

  Fly   293 HPDQ--CSFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGH 355
            :..:  |.|..|:|||:.||.|||::|.:||:.:|.|:|:.|.||.:.:.::....        |
  Rat   185 YAKETCCDFFTNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQLQKIDKSEGRF--------H 241

  Fly   356 TQQPTSLSYLHPSDCDLNATS---AREETHSALSNL 388
            .|..:.:.....|...|..:|   .:|  |.||..|
  Rat   242 AQNLSQVEQDGRSGHGLRRSSKFCLKE--HKALKTL 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	80/201 (40%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	75/189 (40%)
Adrb2	NP_036624.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		8/20 (40%)
		7tm_4	48..340	CDD:304433	86/240 (36%)
		7tm_1	50..326	CDD:278431	85/238 (36%)
		PDZ-binding	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2359
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm44908
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010