DRSC/TRiP Functional Genomics Resources

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Protein Alignment Octbeta3R and Adra2b

DIOPT Version :10

Sequence 1:NP_001034048.2 Gene:Octbeta3R / 3885573 FlyBaseID:FBgn0250910 Length:1256 Species:Drosophila melanogaster
Sequence 2:NP_612514.2 Gene:Adra2b / 24174 RGDID:2057 Length:453 Species:Rattus norvegicus


Alignment Length:335 Identity:106/335 - (31%)
Similarity:159/335 - (47%) Gaps:45/335 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 IILAAVLGNALVIISVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMC 213
            :||..:.||||||::|..:|.||...|.|:||||.||:|||...:.|:.:.||. |.|.|....|
  Rat    27 LILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELL-GYWYFWRAWC 90

  Fly   214 NVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFL 278
            .||.:|||.|.|:||:|||.||:|||:|:.|.|||....|.:.:..::..||::.|:||..|:. 
  Rat    91 EVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLI- 154

  Fly   279 GWYTTEEHLREISLHPDQCSFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQR---KALS 340
              |..::......|  .||.......|.|.||..||:.|.::|:::|.||:..|.|..   ....
  Rat   155 --YKGDQRPEPRGL--PQCELNQEAWYILASSIGSFFAPCLIMILVYLRIYVIAKRSHCRGLGAK 215

  Fly   341 RTSSNILLNSVHMGHTQQPTSLSYLHPSDCDLNATSAREET-HSALSNLEDM----LQPATDEDD 400
            |.|..        |.:::|..::...|       |||:..| .|.||::.:.    ..|...|:.
  Rat   216 RGSGE--------GESKKPQPVAGGVP-------TSAKVPTLVSPLSSVGEANGHPKPPREKEEG 265

  Fly   401 DRDECDELRVPSPPPRRLSRSSIDLRDLEQERYEKVTHTDSAPSMMALQQQQPSHNQLQP----- 460
            :..|..|.|...|....|.||.        :..:|  .|..|.:....::.:....:.:|     
  Rat   266 ETPEDPEARALPPTWSALPRSG--------QGQKK--GTSGATAEEGDEEDEEEVEECEPQTLPA 320

  Fly   461 -PAPVFNPQI 469
             ||.|.||.:
  Rat   321 SPASVCNPPL 330

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Octbeta3RNP_001034048.2 7tmA_DmOct-betaAR-like 142..>338 CDD:320194 76/191 (40%)
TM helix 1 142..167 CDD:320194 9/17 (53%)
TM helix 2 174..200 CDD:320194 12/25 (48%)
TM helix 3 213..243 CDD:320194 19/29 (66%)
TM helix 4 255..278 CDD:320194 6/22 (27%)
TM helix 5 302..331 CDD:320194 11/28 (39%)
7tm_GPCRs <1161..1234 CDD:475119
TM helix 6 1167..1189 CDD:410628
TM helix 7 1202..1227 CDD:410628
Adra2bNP_612514.2 7tmA_alpha2B_AR 12..440 CDD:320444 106/335 (32%)
TM helix 1 19..45 CDD:320444 9/17 (53%)
TM helix 2 52..78 CDD:320444 12/25 (48%)
TM helix 3 90..120 CDD:320444 19/29 (66%)
TM helix 4 132..155 CDD:320444 6/25 (24%)
TM helix 5 174..203 CDD:320444 11/28 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 213..331 30/143 (21%)
TM helix 6 367..397 CDD:320444
TM helix 7 408..433 CDD:320444
Blue background indicates that the domain is not in the aligned region.

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