Protein Alignment Octbeta3R and ser-1

DIOPT Version :10

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_001024728.1
• Gene: ser-1 / 181716
• WormBaseID: WBGene00004776
• Length: 683
• Species: Caenorhabditis elegans
• Alignment Length: 716
• Identity: 163/716 - (22%)
• Similarity: 269/716 - (37%)
• Gaps: 157/716 - (21%)

  Fly   144 FIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMF 208
            |:...:.|..::||.||.:::..:|:|..:||||:.|||:||:||....|..:..||:..|.|.:
 Worm    60 FLLPVLCLIGLIGNFLVCVAIATDRRLHNVTNYFLFSLALADLLVCCIVMPLSIVVEVRHGVWTW 124

  Fly   209 GPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFM-LANVWILPALIS 272
            ...||.:|...||:..:|||:|:..||:|||..|.:||.  .....||:.|: :|.||::..|:|
 Worm   125 SVSMCLLYVYSDVFLCSASIVHMSVISLDRYLGISQPLR--TRNRSKTLIFIKIAIVWVVTLLVS 187

  Fly   273 FTPIFLGWYTTEEHLREISLHPDQCSFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRK 337
            .....|..:.|...||.     :|| .:.::.|.:..|:::|.||..:|.|.|.:..:...:|..
 Worm   188 CPIAVLAMHDTANILRN-----NQC-MIFSRYYIIYGSTMTFLIPLCIMGVTYAKTTQLLNKQAS 246

  Fly   338 ALSRTSSNILLNSVHMGHTQQPTSLSYLHPSDCDLNAT-------SAREETHSALSNLEDMLQPA 395
            .||:.:.: ..|...:..|.....|.|.......:|.|       .|...|.|::||:      |
 Worm   247 ILSQKAGD-KFNGNGLRRTMPHRKLGYARTYSATVNGTIANGKAIGAHGRTMSSISNI------A 304

  Fly   396 TDEDDDR----------DECDELRVPSPPPRRLSRSSIDLRDLEQERYEKVTHTDSAPSMMALQQ 450
            ..|..||          :...:|:..|...:..||:|    :|......||....|..:  |.|.
 Worm   305 NGETADRLGTSRPSINTNGHKQLQKASTINKWKSRTS----NLVTNFANKVGRRSSLQT--ATQD 363

  Fly   451 QQPSHNQLQPPAPVFNPQI--WTEGKMIPSKELDKEHSHPNGPQQQLSLTSGSGNSEPEPESTAY 513
            ....|...:..|.||....  ||                   |...::...|.|....:......
 Worm   364 LANEHKATRVLAVVFACFFICWT-------------------PFFFINFLIGFGGENVQIPDWVA 409

  Fly   514 RVFGGLNSDESEGNDLYDTHLPLAEDNKELKRL------------IEDNYLYFKRQTGGTIISGP 566
            .:|..|....|..|.:..|..     ||..::.            :.|::..:.|....||:
 Worm   410 SIFLWLGYVSSTINPIIYTVF-----NKRFRQAFVRILRCQCFHPLRDSHQMYSRNFTTTIV--- 466

  Fly   567 GGGKYAALSETDFIRLKAGAAACGRKAFASSDSEFLRTISESRALPEQPVPGKEKGFNILSLLSK 631
                             .....|.|.....:.|...|..:.|....|:|.|.:.:     |.:|:
 Worm   467 -----------------PDTYTCSRSNQERTTSVITRDETRSARSSERPEPSRAR-----SEISE 509

  Fly   632 TKRSSTE-CFTLEKKRHQANSEGSSFFRRSRNRKLSHSYNGCGGGKERKLERRQRQHSDTD--ST 693
            ...:.|. ..|.|||:...    .||.|.|.:|.                .|...:.|.||  :.
 Worm   510 EPVARTNGKLTSEKKKISL----PSFPRVSSSRD----------------SRATTEASTTDEETK 554

  Fly   694 PNKPDILLDINVLS---------EQSGASVIQQFSDGVQLIDFSELKTPPERIRSDDELAQLAD- 748
            |..|...:...|::         ::|..::|     .:.|:|    :|.||:.:...:...|..
 Worm   555 PLIPKSTVPATVINIPEQLINPIKKSLTTII-----NMPLLD----ETIPEKAQVHHKSQTLLTS 610

  Fly   749 ------CFGESPQQPATPPPSLSPPELPEPSGLLIASSSELAEIF-RSLSFPLGRPAGAPQRLST 806
                  .|...||||..   |.|..:..:...:|   ||:::::. .|.:.......|||::..|
 Worm   611 STLNFATFSTCPQQPTR---SYSCVDCKKAEKML---SSDVSDMMTTSTASTASTVNGAPRKHLT 669

  Fly   807 L 807
            |
 Worm   670 L 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	64/194 (33%)
		TM helix 1	142..167	CDD:320194	6/22 (27%)
		TM helix 2	174..200	CDD:320194	12/25 (48%)
		TM helix 3	213..243	CDD:320194	13/29 (45%)
		TM helix 4	255..278	CDD:320194	8/23 (35%)
		TM helix 5	302..331	CDD:320194	8/28 (29%)
		7tm_GPCRs	<1161..1234	CDD:475119
		TM helix 6	1167..1189	CDD:410628
		TM helix 7	1202..1227	CDD:410628
ser-1	NP_001024728.1	7tmA_5-HT2	56..438	CDD:320180	108/422 (26%)
		TM helix 1	57..83	CDD:320180	6/22 (27%)
		TM helix 2	90..116	CDD:320180	12/25 (48%)
		TM helix 3	129..159	CDD:320180	13/29 (45%)
		TM helix 4	170..193	CDD:320180	7/22 (32%)
		TM helix 5	211..240	CDD:320180	8/28 (29%)
		TM helix 6	365..395	CDD:320180	7/48 (15%)
		TM helix 7	406..431	CDD:320180	5/29 (17%)