DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta3R and Htr4

DIOPT Version :9

Sequence 1:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_032339.2	Gene:	Htr4 / 15562	MGIID:	109246	Length:	388	Species:	Mus musculus

Alignment Length:	274	Identity:	108/274 - (39%)
Similarity:	152/274 - (55%)	Gaps:	31/274 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   123 VDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVI-TNYFVVSLAMADM 186
            :|......|.:..:..::|..|: :.:||.|:|||.||:::|.|:|:||.| ||||:||||.||:
Mouse     4 LDANVSSNEGFRSVEKVVLLTFL-AVVILMAILGNLLVMVAVCRDRQLRKIKTNYFIVSLAFADL 67

  Fly   187 LVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAI-VRPLEYPL 250
            ||::..|.|.| :||....|.:|...|.|..||||..:||||.||||||:|||||| .:||.|..
Mouse    68 LVSVLVMPFGA-IELVQDIWAYGEMFCLVRTSLDVLLTTASIFHLCCISLDRYYAICCQPLVYRN 131

  Fly   251 NMTHKTVCFMLANVWILPALISFTPIFLGWY------TTEEHLREISLHPDQCSFVVNKAYALIS 309
            .||...:..||...|:||..|||.||..||.      ..|:.....:.:...|.|:|||.||:..
Mouse   132 KMTPLRIALMLGGCWVLPMFISFLPIMQGWNNIGIVDVIEKRKFSHNSNSTWCVFMVNKPYAITC 196

  Fly   310 SSVSFWIPGIVMLVMYWRIF---KEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLSYLHPSDCD 371
            |.|:|:||.::|::.|:||:   ||..:|.:.|.|..:               ||.|  .|...|
Mouse   197 SVVAFYIPFLLMVLAYYRIYVTAKEHAQQIQMLQRAGA---------------TSES--RPQPAD 244

  Fly   372 LNAT-SAREETHSA 384
            .::| ..|.||.:|
Mouse   245 QHSTHRMRTETKAA 258

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	94/210 (45%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	90/198 (45%)
Htr4	NP_032339.2	7tmA_5-HT4	20..323	CDD:320184	106/258 (41%)
		TM helix 1	21..47	CDD:320184	11/26 (42%)
		TM helix 2	55..81	CDD:320184	15/26 (58%)
		TM helix 3	93..123	CDD:320184	21/29 (72%)
		TM helix 4	136..159	CDD:320184	10/22 (45%)
		TM helix 5	189..218	CDD:320184	13/28 (46%)
		TM helix 6	252..282	CDD:320184	4/7 (57%)
		TM helix 7	291..316	CDD:320184
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm42843
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.960