Protein Alignment Octbeta3R and Htr1d

DIOPT Version :10

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_032335.2
• Gene: Htr1d / 15552
• MGIID: 96276
• Length: 374
• Species: Mus musculus
• Alignment Length: 351
• Identity: 97/351 - (27%)
• Similarity: 157/351 - (44%)
• Gaps: 78/351 - (22%)

  Fly   112 PNITANGSDIAVDNQA-ELEESW-------LDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNR 168
            ||.:..|......|:: .:..:|       |.:||::    :.|.|.||.||.||.|:.::...:
Mouse     4 PNQSLEGLPQEASNRSLNVTGAWDPEVLQALRISLVV----VLSVITLATVLSNAFVLTTILLTK 64

  Fly   169 KLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCC 233
            ||....||.:.|||..|:||::..|..:.:...: ..|.||..:|:::.|.|:...||||||||.
Mouse    65 KLHTPANYLIGSLATTDLLVSILVMPISIAYTTT-RTWNFGQILCDIWVSSDITCCTASILHLCV 128

  Fly   234 ISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCS 298
            |::|||:||...|||....|......|:|.|||:...||..|:|  |       |:.:.|.:...
Mouse   129 IALDRYWAITDALEYSKRRTAGHAAAMIAAVWIISICISIPPLF--W-------RQATAHEEMSD 184

  Fly   299 FVVNK---AYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPT 360
            .:||.   :|.:.|:..:|:||.|:::::|.||: .|.|.|          :||         |.
Mouse   185 CLVNTSQISYTIYSTCGAFYIPSILLIILYGRIY-VAARSR----------ILN---------PP 229

  Fly   361 SL------------SYLHPSDCDLNATSAREETHSALSNLEDMLQPATDEDDDRDECDELRVPSP 413
            ||            .....|.|.||.:.....||:..|.|               ..:::::
Mouse   230 SLYGKRFTTAQLITGSAGSSLCSLNPSLHESHTHTVGSPL---------------FFNQVKI--- 276

  Fly   414 PPRRLSRSSIDLRDLEQERYEKVTHT 439
               :|:.|.::.:.:...|..|.|.|
Mouse   277 ---KLADSILERKRISAARERKATKT 299

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	70/198 (35%)
		TM helix 1	142..167	CDD:320194	9/24 (38%)
		TM helix 2	174..200	CDD:320194	9/25 (36%)
		TM helix 3	213..243	CDD:320194	16/29 (55%)
		TM helix 4	255..278	CDD:320194	8/22 (36%)
		TM helix 5	302..331	CDD:320194	10/31 (32%)
		7tm_GPCRs	<1161..1234	CDD:475119
		TM helix 6	1167..1189	CDD:410628
		TM helix 7	1202..1227	CDD:410628
Htr1d	NP_032335.2	7tm_GPCRs	32..364	CDD:475119	92/323 (28%)
		TM helix 1	38..62	CDD:320455	10/27 (37%)
		TM helix 2	71..93	CDD:320455	9/21 (43%)
		TM helix 3	109..131	CDD:320455	11/21 (52%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	132..134		1/1 (100%)
		TM helix 4	154..170	CDD:320455	7/15 (47%)
		TM helix 5	192..215	CDD:320455	6/22 (27%)
		TM helix 6	297..319	CDD:320455	2/3 (67%)
		TM helix 7	332..357	CDD:320455
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	349..353