Protein Alignment Octbeta3R and Htr1a

DIOPT Version :10

• Sequence 1: NP_001034048.2
• Gene: Octbeta3R / 3885573
• FlyBaseID: FBgn0250910
• Length: 1256
• Species: Drosophila melanogaster
• Sequence 2: NP_032334.2
• Gene: Htr1a / 15550
• MGIID: 96273
• Length: 421
• Species: Mus musculus
• Alignment Length: 360
• Identity: 103/360 - (28%)
• Similarity: 171/360 - (47%)
• Gaps: 45/360 - (12%)

  Fly   111 GPNITAN-------GSDIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNR 168
            |.|.|.:       |:|..:.|        :..|..::...:..::|..||||||.|:.::...|
Mouse     9 GNNTTTSLEPFGTGGNDTGLSN--------VTFSYQVITSLLLGTLIFCAVLGNACVVAAIALER 65

  Fly   169 KLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCC 233
            .|:.:.||.:.|||:.|::|::..:...|..::. .||..|...|:::.:|||...|:||||||.
Mouse    66 SLQNVANYLIGSLAVTDLMVSVLVLPMAALYQVL-NKWTLGQVTCDLFIALDVLCCTSSILHLCA 129

  Fly   234 ISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLHPDQCS 298
            |::|||:||..|::|....|.:....:::..|::..|||..|: |||.|.|:.     .:|::|:
Mouse   130 IALDRYWAITDPIDYVNKRTPRRAAALISLTWLIGFLISIPPM-LGWRTPEDR-----SNPNECT 188

  Fly   299 FVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEA-IRQRKALSRTSSNILLNSVHMGHTQQPTSL 362
            ...:..|.:.|:..:|:||.::|||:|.|||:.| .|.||.:.:........|  .|.:..|...
Mouse   189 ISKDHGYTIYSTFGAFYIPLLLMLVLYGRIFRAARFRIRKTVKKVEKKGAGTS--FGTSSAPPPK 251

  Fly   363 SYLH----PSDCDLNATSAREETHSALSNLEDMLQPATDEDDDRDECDEL-RVPS-----PPPRR 417
            ..|:    ..||..:|.:....|..|...:..      .|||...|..|: ||.:     |.|..
Mouse   252 KSLNGQPGSGDCRRSAENRAVGTPCANGAVRQ------GEDDATLEVIEVHRVGNSKGHLPLPSE 310

  Fly   418 LSRSSIDLRDLEQERYEKVTHTDSAPSMMALQQQQ 452
            ...:|.....||:    |...|..|...|||.:::
Mouse   311 SGATSYVPACLER----KNERTAEAKRKMALARER 341

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tmA_DmOct-betaAR-like	142..>338	CDD:320194	68/196 (35%)
		TM helix 1	142..167	CDD:320194	8/24 (33%)
		TM helix 2	174..200	CDD:320194	8/25 (32%)
		TM helix 3	213..243	CDD:320194	16/29 (55%)
		TM helix 4	255..278	CDD:320194	5/22 (23%)
		TM helix 5	302..331	CDD:320194	12/28 (43%)
		7tm_GPCRs	<1161..1234	CDD:475119
		TM helix 6	1167..1189	CDD:410628
		TM helix 7	1202..1227	CDD:410628
Htr1a	NP_032334.2	7tmA_5-HT1A_vertebrates	37..411	CDD:320453	96/324 (30%)
		TM helix 1	38..64	CDD:320453	8/25 (32%)
		TM helix 2	71..97	CDD:320453	8/25 (32%)
		TM helix 3	109..139	CDD:320453	16/29 (55%)
		DRY motif, important for ligand-induced conformation changes. /evidence=ECO:0000250|UniProtKB:P41595	133..135		1/1 (100%)
		TM helix 4	151..173	CDD:320453	5/22 (23%)
		TM helix 5	192..221	CDD:320453	12/28 (43%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	237..268		6/32 (19%)
		TM helix 6	338..368	CDD:320453	0/4 (0%)
		TM helix 7	379..404	CDD:320453
		NPxxY motif, important for ligand-induced conformation changes and signaling. /evidence=ECO:0000250|UniProtKB:P41595	396..400