DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Octbeta3R and ADRB1

DIOPT Version :9

Sequence 1:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_000675.1	Gene:	ADRB1 / 153	HGNCID:	285	Length:	477	Species:	Homo sapiens

Alignment Length:	222	Identity:	82/222 - (36%)
Similarity:	127/222 - (57%)	Gaps:	8/222 - (3%)

- Green bases have known domain annotations that are detailed below.

  Fly   143 GFIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWM 207
            |.:.:.|:|..|.||.|||:::.:..:|:.:||.|::|||.||:::.|..:.|.|:: :..|:|.
Human    62 GLLMALIVLLIVAGNVLVIVAIAKTPRLQTLTNLFIMSLASADLVMGLLVVPFGATI-VVWGRWE 125

  Fly   208 FGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALIS 272
            :|.|.|.::.|:||...||||..||.|::|||.||..|..|...:|......::..||.:.||:|
Human   126 YGSFFCELWTSVDVLCVTASIETLCVIALDRYLAITSPFRYQSLLTRARARGLVCTVWAISALVS 190

  Fly   273 FTPIFLGWYTTE-EHLREISLHPDQCSFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQR 336
            |.||.:.|:..| :..|.....|..|.||.|:|||:.||.|||::|..:|..:|.|:|:||.:|.
Human   191 FLPILMHWWRAESDEARRCYNDPKCCDFVTNRAYAIASSVVSFYVPLCIMAFVYLRVFREAQKQV 255

  Fly   337 KALSRTSSNILLNSVHMGHTQQPTSLS 363
            |.:.......|      |...:|.|.|
Human   256 KKIDSCERRFL------GGPARPPSPS 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	76/200 (38%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	73/188 (39%)
ADRB1	NP_000675.1	7tm_4	67..>266	CDD:304433	76/199 (38%)
		7tm_1	75..377	CDD:278431	78/209 (37%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	269..307		3/8 (38%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	403..477
		PDZ-Binding	474..477
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	230	1.000	Domainoid score	I2451
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328277at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm40768
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	5	5.020