DRSC/TRiP Functional Genomics Resources

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Protein Alignment Octbeta3R and ADRA2B

DIOPT Version :10

Sequence 1:NP_001034048.2 Gene:Octbeta3R / 3885573 FlyBaseID:FBgn0250910 Length:1256 Species:Drosophila melanogaster
Sequence 2:NP_000673.2 Gene:ADRA2B / 151 HGNCID:282 Length:450 Species:Homo sapiens


Alignment Length:313 Identity:99/313 - (31%)
Similarity:148/313 - (47%) Gaps:55/313 - (17%)


- Green bases have known domain annotations that are detailed below.


  Fly   149 IILAAVLGNALVIISVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMC 213
            :||..:.||||||::|..:|.||...|.|:||||.||:|||...:.|:.:.||. |.|.|....|
Human    22 LILFTIFGNALVILAVLTSRSLRAPQNLFLVSLAAADILVATLIIPFSLANELL-GYWYFRRTWC 85

  Fly   214 NVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTP-IF 277
            .||.:|||.|.|:||:|||.||:|||:|:.|.|||....|.:.:..::..||::.|:||..| |:
Human    86 EVYLALDVLFCTSSIVHLCAISLDRYWAVSRALEYNSKRTPRRIKCIILTVWLIAAVISLPPLIY 150

  Fly   278 LGWYTTEEHLREISLHPDQCSFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRK----- 337
            .|....:...|      .||.......|.|.||..||:.|.::|:::|.||:..|.|..:     
Human   151 KGDQGPQPRGR------PQCKLNQEAWYILASSIGSFFAPCLIMILVYLRIYLIAKRSNRRGPRA 209

  Fly   338 --------------------------ALSRTSSNILLNSVHM--------GHTQQPTSLSYLHPS 368
                                      ||:..:|...:|. |.        |.|.:.|....|.||
Human   210 KGGPGQGESKQPRPDHGGALASAKLPALASVASAREVNG-HSKSTGEKEEGETPEDTGTRALPPS 273

  Fly   369 DCDLNATSAREETHSALSNLEDMLQPATDEDDDRDECDELRVP-------SPP 414
            ...|..:...::.....::.||..:...:|:::.:||:...||       |||
Human   274 WAALPNSGQGQKEGVCGASPEDEAEEEEEEEEEEEECEPQAVPVSPASACSPP 326

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Octbeta3RNP_001034048.2 7tmA_DmOct-betaAR-like 142..>338 CDD:320194 77/220 (35%)
TM helix 1 142..167 CDD:320194 9/17 (53%)
TM helix 2 174..200 CDD:320194 12/25 (48%)
TM helix 3 213..243 CDD:320194 19/29 (66%)
TM helix 4 255..278 CDD:320194 7/23 (30%)
TM helix 5 302..331 CDD:320194 11/28 (39%)
7tm_GPCRs <1161..1234 CDD:475119
TM helix 6 1167..1189 CDD:410628
TM helix 7 1202..1227 CDD:410628
ADRA2BNP_000673.2 7tmA_alpha2B_AR 7..437 CDD:320444 99/313 (32%)
TM helix 1 14..40 CDD:320444 9/17 (53%)
TM helix 2 47..73 CDD:320444 12/25 (48%)
TM helix 3 85..115 CDD:320444 19/29 (66%)
TM helix 4 127..150 CDD:320444 6/22 (27%)
TM helix 5 169..198 CDD:320444 11/28 (39%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 204..229 0/24 (0%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 241..329 20/87 (23%)
TM helix 6 364..394 CDD:320444
TM helix 7 405..430 CDD:320444
Blue background indicates that the domain is not in the aligned region.

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