DRSC/TRiP Functional Genomics Resources

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Protein Alignment Octbeta3R and ADRA2A

DIOPT Version :10

Sequence 1:NP_001034048.2 Gene:Octbeta3R / 3885573 FlyBaseID:FBgn0250910 Length:1256 Species:Drosophila melanogaster
Sequence 2:NP_000672.3 Gene:ADRA2A / 150 HGNCID:281 Length:465 Species:Homo sapiens


Alignment Length:383 Identity:108/383 - (28%)
Similarity:176/383 - (45%) Gaps:50/383 - (13%)


- Green bases have known domain annotations that are detailed below.


  Fly   100 SDSTFELLSTVGP---NITANGSDIAVDN-QAELEESWLDLSLLLLKGFIFSSIILAAVLGNALV 160
            ::.:|..:.::.|   |.:.||::..... :|......:.|:|:.|.|.    ::|..|.||.||
Human     9 AEGSFAPMGSLQPDAGNASWNGTEAPGGGARATPYSLQVTLTLVCLAGL----LMLLTVFGNVLV 69

  Fly   161 IISVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFST 225
            ||:|..:|.|:...|.|:||||.||:|||...:.|:.:.|:. |.|.||...|.:|.:|||.|.|
Human    70 IIAVFTSRALKAPQNLFLVSLASADILVATLVIPFSLANEVM-GYWYFGKAWCEIYLALDVLFCT 133

  Fly   226 ASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREI 290
            :||:|||.||:|||::|.:.:||.|..|.:.:..::..||::.|:|||.|:             |
Human   134 SSIVHLCAISLDRYWSITQAIEYNLKRTPRRIKAIIITVWVISAVISFPPL-------------I 185

  Fly   291 SLH-----------PDQCSFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSS 344
            |:.           ..:|.....|.|.:.|...||:.|.::|:::|.||::.|.|:.:.......
Human   186 SIEKKGGGGGPQPAEPRCEINDQKWYVISSCIGSFFAPCLIMILVYVRIYQIAKRRTRVPPSRRG 250

  Fly   345 NILLNSVHMGHTQQPTSLSYLHPSDCDLNATSAREETHSALSNLEDMLQPATDEDDDRDECDEL- 408
            ...:.:...|..::|..|.   |........:..|...:.|:.......||...|.|..:.:|. 
Human   251 PDAVAAPPGGTERRPNGLG---PERSAGPGGAEAEPLPTQLNGAPGEPAPAGPRDTDALDLEESS 312

  Fly   409 ---RVPSPP-PRRLSRSSIDLRDLEQERYEKVTHTDSAPSMMALQQQQPSHNQLQPPA 462
               ....|| |||..|..   |...:.|..:|...||.|      ::.|....:..||
Human   313 SSDHAERPPGPRRPERGP---RGKGKARASQVKPGDSLP------RRGPGATGIGTPA 361

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Octbeta3RNP_001034048.2 7tmA_DmOct-betaAR-like 142..>338 CDD:320194 73/206 (35%)
TM helix 1 142..167 CDD:320194 10/24 (42%)
TM helix 2 174..200 CDD:320194 12/25 (48%)
TM helix 3 213..243 CDD:320194 17/29 (59%)
TM helix 4 255..278 CDD:320194 7/22 (32%)
TM helix 5 302..331 CDD:320194 10/28 (36%)
7tm_GPCRs <1161..1234 CDD:475119
TM helix 6 1167..1189 CDD:410628
TM helix 7 1202..1227 CDD:410628
ADRA2ANP_000672.3 7tmA_alpha2A_AR 49..452 CDD:320445 102/343 (30%)
TM helix 1 50..76 CDD:320445 12/29 (41%)
TM helix 2 83..109 CDD:320445 12/25 (48%)
TM helix 3 121..151 CDD:320445 17/29 (59%)
TM helix 4 163..186 CDD:320445 7/35 (20%)
TM helix 5 208..237 CDD:320445 10/28 (36%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 242..368 26/132 (20%)
PHA03307 244..>389 CDD:223039 26/130 (20%)
TM helix 6 382..412 CDD:320445
TM helix 7 420..445 CDD:320445
Blue background indicates that the domain is not in the aligned region.

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