DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta3R and Adrb2

DIOPT Version :9

Sequence 1:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_031446.2	Gene:	Adrb2 / 11555	MGIID:	87938	Length:	418	Species:	Mus musculus

Alignment Length:	295	Identity:	100/295 - (33%)
Similarity:	154/295 - (52%)	Gaps:	36/295 - (12%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 VGPNITANGSDIAV----------DNQAELEESW-LDLSLLLLKGFIFSSIILAAVLGNALVIIS 163
            :||:  .|.||..:          |...|.:|:| :.:::|:      |.|:||.|.||.|||.:
Mouse     1 MGPH--GNDSDFLLAPNGSRAPDHDVTQERDEAWVVGMAILM------SVIVLAIVFGNVLVITA 57

  Fly   164 VQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASI 228
            :.:..:|:.:||||::|||.||:::.|..:.|.|| .:....|.||.|.|..:.|:||...||||
Mouse    58 IAKFERLQTVTNYFIISLACADLVMGLAVVPFGAS-HILMKMWNFGNFWCEFWTSIDVLCVTASI 121

  Fly   229 LHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHLREISLH 293
            ..||.|:||||.||..|.:|...:|......::..|||:..|.||.||.:.||.. .|.:.|..:
Mouse   122 ETLCVIAVDRYVAITSPFKYQSLLTKNKARVVILMVWIVSGLTSFLPIQMHWYRA-THKKAIDCY 185

  Fly   294 PDQ--CSFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHT 356
            .::  |.|..|:|||:.||.|||::|.:||:.:|.|:|:.|.||.:.:.::....        |.
Mouse   186 TEETCCDFFTNQAYAIASSIVSFYVPLVVMVFVYSRVFQVAKRQLQKIDKSEGRF--------HA 242

  Fly   357 QQPTSLSYLHPSDCDLNATS---AREETHSALSNL 388
            |..:.:.....|...|..:|   .:|  |.||..|
Mouse   243 QNLSQVEQDGRSGHGLRRSSKFCLKE--HKALKTL 275

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	80/201 (40%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	75/189 (40%)
Adrb2	NP_031446.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..23		5/23 (22%)
		7tm_4	48..340	CDD:304433	86/240 (36%)
		7tm_1	50..326	CDD:278431	85/238 (36%)
		PDZ-binding	415..418
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	228	1.000	Domainoid score	I2479
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm8780
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	5	5.010