DRSC/TRiP Functional Genomics Resources

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Protein Alignment Octbeta3R and CHRM5

DIOPT Version :10

Sequence 1:NP_001034048.2 Gene:Octbeta3R / 3885573 FlyBaseID:FBgn0250910 Length:1256 Species:Drosophila melanogaster
Sequence 2:NP_036257.1 Gene:CHRM5 / 1133 HGNCID:1954 Length:532 Species:Homo sapiens


Alignment Length:432 Identity:109/432 - (25%)
Similarity:177/432 - (40%) Gaps:98/432 - (22%)


- Green bases have known domain annotations that are detailed below.


  Fly   115 TANGSDIAVDNQAELEES--WLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNYF 177
            |.||:.:   |...||..  |..:::    ..:.:.:.|..::||.||:||.:.|.:|:.:.||:
Human    11 TVNGTPV---NHQPLERHRLWEVITI----AAVTAVVSLITIVGNVLVMISFKVNSQLKTVNNYY 68

  Fly   178 VVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAI 242
            ::|||.||:::.:.:|....:..|. |:|..|...|:::.:||...|.||:::|..||.|||::|
Human    69 LLSLACADLIIGIFSMNLYTTYILM-GRWALGSLACDLWLALDYVASNASVMNLLVISFDRYFSI 132

  Fly   243 VRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEHL---REISLHPDQCSFVVNKA 304
            .|||.|....|.|....|:...|:: :.|.:.|..|.|    ::|   |.:.|...|..|:....
Human   133 TRPLTYRAKRTPKRAGIMIGLAWLI-SFILWAPAILCW----QYLVGKRTVPLDECQIQFLSEPT 192

  Fly   305 YALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSLSYLHPSD 369
            ....::..:|:||..||.::|.||::|..::.|                       .|:.|..||
Human   193 ITFGTAIAAFYIPVSVMTILYCRIYRETEKRTK-----------------------DLADLQGSD 234

  Fly   370 CDLNATSAREETHSALSNLEDMLQPATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDLEQERY- 433
             .:.....|:..|.||..                .|  ||.|.|        ::..|:..|..: 
Human   235 -SVTKAEKRKPAHRALFR----------------SC--LRCPRP--------TLAQRERNQASWS 272

  Fly   434 --EKVTHTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMI------PSKELDKEHSHPNG 490
              .:.|.|...||    |...||.|             |.:.:.:      ||.|  .|......
Human   273 SSRRSTSTTGKPS----QATGPSAN-------------WAKAEQLTTCSSYPSSE--DEDKPATD 318

  Fly   491 PQQQLSLTSGSGNSEPEPESTAYRVFGGLNSDESEGNDLYDT 532
            |..|:...| .|...|..|.:|..........|:|.:| |||
Human   319 PVLQVVYKS-QGKESPGEEFSAEETEETFVKAETEKSD-YDT 358

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Octbeta3RNP_001034048.2 7tmA_DmOct-betaAR-like 142..>338 CDD:320194 60/198 (30%)
TM helix 1 142..167 CDD:320194 7/24 (29%)
TM helix 2 174..200 CDD:320194 8/25 (32%)
TM helix 3 213..243 CDD:320194 12/29 (41%)
TM helix 4 255..278 CDD:320194 5/22 (23%)
TM helix 5 302..331 CDD:320194 8/28 (29%)
7tm_GPCRs <1161..1234 CDD:475119
TM helix 6 1167..1189 CDD:410628
TM helix 7 1202..1227 CDD:410628
CHRM5NP_036257.1 7tmA_mAChR_M5 31..>225 CDD:320427 60/203 (30%)
TM helix 1 32..58 CDD:320427 7/29 (24%)
TM helix 2 65..91 CDD:320427 8/25 (32%)
TM helix 3 103..133 CDD:320427 12/29 (41%)
TM helix 4 145..168 CDD:320427 5/23 (22%)
TM helix 5 190..219 CDD:320427 8/28 (29%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 262..294 10/48 (21%)
7tm_GPCRs <435..514 CDD:475119
TM helix 6 441..463 CDD:410628
TM helix 7 474..499 CDD:410628
Blue background indicates that the domain is not in the aligned region.

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