DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta3R and htr4

DIOPT Version :9

Sequence 1:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_002939852.1	Gene:	htr4 / 100493952	XenbaseID:	XB-GENE-993770	Length:	386	Species:	Xenopus tropicalis

Alignment Length:	285	Identity:	113/285 - (39%)
Similarity:	157/285 - (55%)	Gaps:	46/285 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 NITAN-GSDIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVI-TN 175
            |:|:| |..:|              :.::|..|| |::||..:|||.||:::|.|:|:||.| ||
Frog     6 NVTSNEGYGVA--------------ARIVLISFI-SAVILMTILGNLLVMVAVCRDRQLRKIKTN 55

  Fly   176 YFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYY 240
            ||:||||.||:||::..|.|.| :||...||::|...|.|..||||..:|||||||||||:||||
Frog    56 YFIVSLAFADLLVSVLVMPFGA-IELVQEKWIYGEMFCLVRTSLDVLLTTASILHLCCISLDRYY 119

  Fly   241 AI-VRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYT------TEEHLREISLHPDQCS 298
            || .:||.|...||...:..||:..||:|..|||.||..||.:      .|......|.:...|.
Frog   120 AICCQPLVYRNKMTPLRITLMLSGCWIIPTFISFLPIMQGWNSIGILDLIETRKYNKSSNSTNCI 184

  Fly   299 FVVNKAYALISSSVSFWIPGIVMLVMYWRIF---KEAIRQRKALSRTSSNILLNSVHMGHTQQPT 360
            |:|||.||:..|.|:|:||..:|::.|:||:   :|..||...|.|..:              |.
Frog   185 FMVNKPYAITCSVVAFYIPFFLMVLAYYRIYITAREHARQIGVLQRAGA--------------PA 235

  Fly   361 SLSYLHPSDCDLNAT-SAREETHSA 384
            ...:.||   |.:.| ..:.||.:|
Frog   236 DHRHQHP---DQHTTHRMKTETKAA 257

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	97/210 (46%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	93/198 (47%)
htr4	XP_002939852.1	7tmA_5-HT4	19..322	CDD:320184	108/258 (42%)
		TM helix 1	20..46	CDD:320184	12/26 (46%)
		TM helix 2	54..80	CDD:320184	15/26 (58%)
		TM helix 3	92..122	CDD:320184	22/29 (76%)
		TM helix 4	135..158	CDD:320184	10/22 (45%)
		TM helix 5	188..217	CDD:320184	13/28 (46%)
		TM helix 6	251..281	CDD:320184	3/7 (43%)
		TM helix 7	290..315	CDD:320184
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328277at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14086
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	3.010