DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta3R and hrh2

DIOPT Version :9

Sequence 1:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_002938111.2	Gene:	hrh2 / 100491392	XenbaseID:	XB-GENE-991059	Length:	387	Species:	Xenopus tropicalis

Alignment Length:	212	Identity:	79/212 - (37%)
Similarity:	128/212 - (60%)	Gaps:	2/212 - (0%)

- Green bases have known domain annotations that are detailed below.

  Fly   133 WLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNA 197
            |..:...:|.|.:...||:..:.||.:|.::|..:||||.:||.|:||||:.|:|:.:..:.|:|
Frog    17 WKSVLYNVLIGAVLVLIIIITICGNVVVCLAVGLDRKLRSMTNCFIVSLAITDLLLGILVLPFSA 81

  Fly   198 SVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLA 262
             :.|...:|.||...||:|.||||...|||||:|..||:||||.:..||.|.:::|...|...:.
Frog    82 -LNLLHEEWPFGATFCNIYTSLDVMLCTASILNLFMISLDRYYGVTAPLRYSMHVTPFRVAIAMC 145

  Fly   263 NVWILPALISFTPIFLGWYTTEEHLREISLHPD-QCSFVVNKAYALISSSVSFWIPGIVMLVMYW 326
            .:|::..::||.||.|||.|.::.::......| :|...:||.|.|:...::|::|..:|.:||:
Frog   146 VIWVVSLMVSFLPIHLGWNTKDKSIQNYRDSNDKECKLELNKEYVLVDGLLTFYLPLSIMCLMYY 210

  Fly   327 RIFKEAIRQRKALSRTS 343
            ||||.|..|.|.::..:
Frog   211 RIFKIAREQAKRINHAN 227

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	76/199 (38%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	74/189 (39%)
hrh2	XP_002938111.2	7tmA_Histamine_H2R	24..310	CDD:320179	78/205 (38%)
		TM helix 1	25..51	CDD:320179	8/25 (32%)
		TM helix 2	58..85	CDD:320179	11/27 (41%)
		TM helix 3	96..126	CDD:320179	19/29 (66%)
		TM helix 4	138..158	CDD:320179	4/19 (21%)
		TM helix 5	186..216	CDD:320179	13/29 (45%)
		TM helix 6	239..269	CDD:320179
		TM helix 7	278..303	CDD:320179
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H40613
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.000