DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta3R and adrb1

DIOPT Version :9

Sequence 1:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	XP_002932739.1	Gene:	adrb1 / 100487086	XenbaseID:	XB-GENE-6034588	Length:	408	Species:	Xenopus tropicalis

Alignment Length:	465	Identity:	126/465 - (27%)
Similarity:	189/465 - (40%)	Gaps:	125/465 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    98 LSSDSTFELLSTVGPNITANGSDIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVII 162
            |:|..||       |.:.:||:            :||.|:...:.|.:.|.:|:..|.||.||||
Frog     7 LNSTGTF-------PEVDSNGT------------TWLSLTQRWMLGAVLSFMIMVIVFGNMLVII 52

  Fly   163 SVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTAS 227
            ::.:..:|:.:||.|:.|||.||:::.|..:...|:: |..|.|:|...:|.::.|:||...|||
Frog    53 AIAKTPRLQTMTNVFITSLACADLIMGLLVVPPGATI-LVTGDWLFETTVCELWTSVDVLCVTAS 116

  Fly   228 ILHLCCISVDRYYAIVRPLEYPLNMT----HKTVCFMLANVWILPALISFTPIFLGWY--TTEEH 286
            |..||.|:||||.||..||:|.:.:|    ..|||.    ||.:.|||||.||...|:  |..|.
Frog   117 IETLCVIAVDRYIAITSPLKYEMLVTKVRARLTVCL----VWAISALISFLPIMNRWWRDTHNEE 177

  Fly   287 LREISLHPDQCSFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSV 351
            .:....:|..|.||.|..||::||::||::|.::|:.:|.|:|..|.||.:.:.:       :.|
Frog   178 AKSCYDNPKCCDFVTNMPYAIVSSTISFYVPLVIMIFVYVRVFIVATRQVRLIEK-------DKV 235

  Fly   352 HMGHTQQPTSLSYLHPSDCDLNATSARE-------ETHSALSNL--------------------- 388
            ....|..||:.|         ...|.|.       :.|.||..|
Frog   236 RFNGTPVPTNKS---------RRASRRRPSGLLAIKEHKALKTLGIIMGIFTLCWLPFFVANIIK 291

  Fly   389 ---------------------EDMLQP---ATDEDDDRDECDELRVPSPPPRRLSRSSIDLRDLE 429
                                 ...|.|   ....|..|.....||.|....|:|...|   :||.
Frog   292 VFCRSFIDDNVFLFLNWLGYINSGLNPIIYCRSPDFRRAFRKLLRCPRTVDRKLHALS---KDLN 353

  Fly   430 QERYEKVTHTDSAPSMMALQQQQPSHNQLQPPAPVFNPQIWTEGKMIPSKELDKEHSHPNGPQQQ 494
            :..|...||.|..........|:|.:..|                        ...|..:...::
Frog   354 RYPYTSGTHLDCDGIKQVPDGQEPGNGSL------------------------SSSSRCSSRTEE 394

  Fly   495 LSLTSGSGNS 504
            .||.:|:.||
Frog   395 TSLKNGNANS 404

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	79/205 (39%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	76/193 (39%)
adrb1	XP_002932739.1	7tmA_Beta3_AR	30..331	CDD:320625	95/321 (30%)
		TM helix 1	31..57	CDD:320625	10/25 (40%)
		TM helix 2	64..91	CDD:320625	10/27 (37%)
		TM helix 3	102..132	CDD:320625	16/29 (55%)
		TM helix 4	146..164	CDD:320625	10/21 (48%)
		TM helix 5	193..225	CDD:320625	13/31 (42%)
		TM helix 6	261..291	CDD:320625	4/29 (14%)
		TM helix 7	300..325	CDD:320625	2/24 (8%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D328277at33208
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	1.010