DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta3R and adrb2

DIOPT Version :9

Sequence 1:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001116897.2	Gene:	adrb2 / 100144654	XenbaseID:	XB-GENE-494302	Length:	419	Species:	Xenopus tropicalis

Alignment Length:	310	Identity:	108/310 - (34%)
Similarity:	159/310 - (51%)	Gaps:	52/310 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly    91 SSPFSSYLSSDSTFE-LLSTVGPNITANGSDIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAV 154
            :||:     .:||.| |:|.|  :.|:|.||...|       :|     ::..|.|.|.|:|..|
Frog     7 ASPY-----PNSTLEQLVSNV--SNTSNASDKPGD-------AW-----MVGMGIIMSCIVLVIV 52

  Fly   155 LGNALVIISVQRNRKLRVITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSL 219
            |||.|||.::.:.::|:.:||||:.|||.||:|:.|..:.|.|| .:....|:|..|.|..:.|:
Frog    53 LGNVLVITAIAKFQRLQTVTNYFITSLACADLLMGLIVVPFGAS-SIILDTWVFNNFWCEFWTSV 116

  Fly   220 DVYFSTASILHLCCISVDRYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTE 284
            |:...||||..||.|:||||:||..|..|...:|......::..||::..|.||.||::.||..|
Frog   117 DILCVTASIETLCVIAVDRYFAITSPFRYQSLLTKCKARIVILLVWVVSTLTSFLPIYMHWYRIE 181

  Fly   285 EHLREISLH----PDQCSFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSN 345
            |   |.:||    |..|.|..|.|||:.||.:||::|.:||:.:|.|:|:||.:|.|.:.::...
Frog   182 E---ESALHCYDDPSCCFFFTNPAYAISSSIISFYLPLVVMIFVYARVFQEAKKQLKKIDKSEGR 243

  Fly   346 ILLNSVHMGHTQQPTSLSYLHPSDCDLNATSAREET-------HSALSNL 388
            .     |..:.||            |.|.....:.|       |.||..|
Frog   244 F-----HNQNNQQ------------DTNGKQGNKRTSKFWLKEHKALKTL 276

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	82/203 (40%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	77/191 (40%)
adrb2	NP_001116897.2	7tmA_Beta2_AR	38..337	CDD:341355	94/260 (36%)
		TM helix 1	39..65	CDD:341355	12/25 (48%)
		TM helix 2	72..99	CDD:341355	14/27 (52%)
		TM helix 3	110..140	CDD:341355	15/29 (52%)
		TM helix 4	152..175	CDD:341355	7/22 (32%)
		TM helix 5	200..232	CDD:341355	16/31 (52%)
		TM helix 6	267..297	CDD:341355	4/10 (40%)
		TM helix 7	306..331	CDD:341355
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		mtm14086
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	3.010