DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Octbeta3R and adrb2b

DIOPT Version :9

Sequence 1:	NP_001034048.2	Gene:	Octbeta3R / 3885573	FlyBaseID:	FBgn0250910	Length:	1256	Species:	Drosophila melanogaster
Sequence 2:	NP_001082940.2	Gene:	adrb2b / 100037315	ZFINID:	ZDB-GENE-070410-32	Length:	409	Species:	Danio rerio

Alignment Length:	286	Identity:	100/286 - (34%)
Similarity:	148/286 - (51%)	Gaps:	34/286 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 NITA--NGS---DIAVDNQAELEESWLDLSLLLLKGFIFSSIILAAVLGNALVIISVQRNRKLRV 172
            ||:|  |.|   .::|...::.|        ::|...:...::|..|.||||||.::.|.::|:.
Zfish    17 NISAGLNASSPVSLSVSEYSDAE--------VVLISILIGILVLVIVFGNALVISAIVRFQRLQT 73

  Fly   173 ITNYFVVSLAMADMLVALCAMTFNASVELSGGKWMFGPFMCNVYNSLDVYFSTASILHLCCISVD 237
            :||||:.|||.||:::.|..:.|.|...|. ..|.||.|.|..:.:.||...||||..||.|::|
Zfish    74 VTNYFISSLACADLVMGLMVVPFGACYILL-NTWHFGNFFCEFWTATDVLCVTASIETLCVIALD 137

  Fly   238 RYYAIVRPLEYPLNMTHKTVCFMLANVWILPALISFTPIFLGWYTTEEH-----LREISLHPDQC 297
            ||.||:.||.|...:|.:..|.|:..||.:.|||||.||.:.|:.::|.     |.|    |..|
Zfish   138 RYIAIMWPLRYQSMLTKRKACGMVIGVWAVAALISFLPIHMEWWVSDEPEALSCLEE----PTCC 198

  Fly   298 SFVVNKAYALISSSVSFWIPGIVMLVMYWRIFKEAIRQRKALSRTSSNILLNSVHMGHTQQPTSL 362
            .|..|.|||:.||.:||:||.::|..:|.|:|:||.||.:.:.|....|...|:   .||:...:
Zfish   199 DFNTNAAYAVTSSIISFYIPLVIMAFVYSRVFQEARRQLQKIDRIEGRIRTQSL---STQEGNEI 260

  Fly   363 SYLHPSDCDLNATSAREETHSALSNL 388
            .......|        .:.|.||..|
Zfish   261 KNRRTKFC--------MKDHKALKTL 278

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Octbeta3R	NP_001034048.2	7tm_4	146..>346	CDD:304433	83/204 (41%)
Octbeta3R	NP_001034048.2	7tm_1	156..>344	CDD:278431	81/192 (42%)
adrb2b	NP_001082940.2	7tm_GPCRs	41..339	CDD:333717	93/254 (37%)
		TM helix 1	43..67	CDD:320095	8/23 (35%)
		TM helix 2	76..98	CDD:320095	10/21 (48%)
		TM helix 3	114..136	CDD:320095	9/21 (43%)
		TM helix 4	159..175	CDD:320095	8/15 (53%)
		TM helix 5	204..227	CDD:320095	10/22 (45%)
		TM helix 6	272..297	CDD:320095	4/7 (57%)
		TM helix 7	308..333	CDD:320095
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR24248
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	2.010