DRSC/TRiP Functional Genomics Resources

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Protein Alignment Dyrk3 and DYRK1B

DIOPT Version :9

Sequence 1:NP_001033810.1 Gene:Dyrk3 / 3885567 FlyBaseID:FBgn0027101 Length:828 Species:Drosophila melanogaster
Sequence 2:NP_004705.1 Gene:DYRK1B / 9149 HGNCID:3092 Length:629 Species:Homo sapiens


Alignment Length:511 Identity:191/511 - (37%)
Similarity:269/511 - (52%) Gaps:58/511 - (11%)


- Green bases have known domain annotations that are detailed below.


  Fly   230 ILTYPQIYFIGANAKKRPGVYGP-----NNSE-------YDNEQGAYIHVPHDHVAYRYEMLKII 282
            |.||..|..:....|||.....|     |..|       ||::...||....:....|||:..:|
Human    53 IKTYKHINEVYYAKKKRRAQQAPPQDSSNKKEKKVLNHGYDDDNHDYIVRSGERWLERYEIDSLI 117

  Fly   283 GKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTF 347
            ||||||||:|||||:|.|.||:||::|:|.|..|||.|:|:|..:.:||......|:|:..:|.|
Human   118 GKGSFGQVVKAYDHQTQELVAIKIIKNKKAFLNQAQIELRLLELMNQHDTEMKYYIVHLKRHFMF 182

  Fly   348 RNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALY----KNDIIHCDMKPENV 408
            |||.|:.|||||.|||:|::...|:|.||.|.||.|..|  |...|:    :..|||||:||||:
Human   183 RNHLCLVFELLSYNLYDLLRNTHFRGVSLNLTRKLAQQL--CTALLFLATPELSIIHCDLKPENI 245

  Fly   409 LLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGH 473
            ||....||.||::||||||...||||.||||||||:|||:||..|..|||||||||||.|:.:|.
Human   246 LLCNPKRSAIKIVDFGSSCQLGQRIYQYIQSRFYRSPEVLLGTPYDLAIDMWSLGCILVEMHTGE 310

  Fly   474 ALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFS--PKGYPRYCTVRTMSDGMVVLIGGQS 536
            .||.|.||.||:..|:||||:|...:|..:.:::.:|.  |.|   ..|:|...:......|..:
Human   311 PLFSGSNEVDQMNRIVEVLGIPPAAMLDQAPKARKYFERLPGG---GWTLRRTKELRKDYQGPGT 372

  Fly   537 RR-----GKQRGPPCSKSLSKALDGCKDPL-FLNFIRGCLEWDADKRLTPSEALKHPWLRRRLPR 595
            ||     |.|.|.|..:...:......|.| |.:.:...||::...|::|..||:|.:.||....
Human   373 RRLQEVLGVQTGGPGGRRAGEPGHSPADYLRFQDLVLRMLEYEPAARISPLGALQHGFFRRTADE 437

  Fly   596 PPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAETTASSTSATSISLTIKRENSHSSLRLHH---- 656
            ..::     |.:|..:|.:.:|:         :|..||::|:|||.:.....|.|..|.:.    
Human   438 ATNT-----GPAGSSASTSPAPL---------DTCPSSSTASSISSSGGSSGSSSDNRTYRYSNR 488

  Fly   657 ----GAVPETDFKLIKSVPEGSSTATKEPMMNSDILPESFRQTTVVSPSKHSADSG 708
                ...|.||.::  :.|:...:....|....|: |....|    :|:..|:..|
Human   489 YCGGPGPPITDCEM--NSPQVPPSQPLRPWAGGDV-PHKTHQ----APASASSLPG 537

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
Dyrk3NP_001033810.1 PKc_DYRK2_3 211..589 CDD:271126 164/382 (43%)
S_TKc 276..589 CDD:214567 149/324 (46%)
DYRK1BNP_004705.1 Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 67..89 6/21 (29%)
Bipartite nuclear localization signal. /evidence=ECO:0000255 69..86 4/16 (25%)
PKc_DYRK1 97..436 CDD:271128 154/343 (45%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 380..399 4/18 (22%)
Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite 436..629 25/123 (20%)
Interaction with RANBP9. /evidence=ECO:0000269|PubMed:14500717 480..520 6/41 (15%)


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 00.000 Not matched by this tool.
Domainoid 00.000 Not matched by this tool.
eggNOG 1 0.900 - - E1_KOG0667
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 1 0.910 - -
RoundUp 1 1.030 - avgDist Average_Evolutionary_Distance R968
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
32.840

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