DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and DYRK2

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_006473.2	Gene:	DYRK2 / 8445	HGNCID:	3093	Length:	601	Species:	Homo sapiens

Alignment Length:	544	Identity:	316/544 - (58%)
Similarity:	383/544 - (70%)	Gaps:	55/544 - (10%)

- Green bases have known domain annotations that are detailed below.

  Fly   113 GDIQILPIFDCCEISESIQAISLPNVTSPSKT--KDVPGLFLRTISENSKSKSEPECESLISVKE 175
            |.||:..:|:......::.......:|:..||  ..||...|.:|.....|.:        |:|.
Human    86 GQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKTGLPVVPERQLDSIHRRQGSST--------SLKS 142

  Fly   176 SSVMENHTFLFHEQIIMSGQQKCELHEKPKVLVVSPQQVMILYMNKLTPYERTEILTYPQIYFIG 240
                            |.|..|.      |...::|:|.|..||.|||.:|..||.:||:|||:|
Human   143 ----------------MEGMGKV------KATPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFLG 185

  Fly   241 ANAKKRPGVY-GPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVAL 304
            .|||||.|:. ||||..||::||:|:.|||||||||||:||:|||||||||:||||||.|:||||
Human   186 LNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVAL 250

  Fly   305 KIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKN 369
            |:|||||||||||.||||||.|||:.||.||||:|||.:.||||||.|:||||||:|||||||||
Human   251 KMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKKN 315

  Fly   370 GFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIY 434
            .|:||||.||||||||:|||||||:||.|||||:||||:|||||||||||||||||||:|:||:|
Human   316 KFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSGIKVIDFGSSCYEHQRVY 380

  Fly   435 TYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNI 499
            ||||||||||||||||.:||..||||||||||||||:|:.|.|||:|.|||||:||:||||::.:
Human   381 TYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQKL 445

  Fly   500 LASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLN 564
            |.:|||:|:|.|.|||||||||.|:|||.|||.||:|||||.||||.|:....||.||.|||||:
Human   446 LDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFLD 510

  Fly   565 FIRGCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAET 629
            |::.|||||...|:||.:||:|||||||||:||                     ||: :......
Human   511 FLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPP---------------------TGE-KTSVKRI 553

  Fly   630 TASSTSATSISLTIKRENSHSSLR 653
            |.|:.:.||||......:|.|.||
Human   554 TESTGAITSISKLPPPSSSASKLR 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	277/378 (73%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	236/312 (76%)
DYRK2	NP_006473.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..24
		PKc_DYRK2_3	156..535	CDD:271126	277/378 (73%)
		Nuclear localization signal. /evidence=ECO:0000305\|PubMed:19965871	189..191		1/1 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	510	1.000	Domainoid score	I321
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H48437
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	1	1.000	-	-		otm41560
orthoMCL	1	0.900	-	-		OOG6_100394
Panther	1	1.100	-	-	LDO	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X888
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
User_Submission	0	0.000	Not matched by this tool.
	12	11.810