DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dyrk3 and AT3G17750

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_188402.1	Gene:	AT3G17750 / 821043	AraportID:	AT3G17750	Length:	1138	Species:	Arabidopsis thaliana

Alignment Length:	569	Identity:	165/569 - (28%)
Similarity:	266/569 - (46%)	Gaps:	127/569 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly   111 YPG-----DIQILPIFDCCEISESIQAISLPNVTSPSKTKDVPG---------------LFLRTI 155
            :||     |:::||          .:.:.:..|..|      ||               .|...:
plant   618 FPGEGSEWDLELLP----------YRGVGVAGVKPP------PGKGASMLLKNFADGGFSFPSPV 666

  Fly   156 SENSKSKSE---PE----CESLISVKESSVMENHTFLFHEQIIMSGQQKC--------------- 198
            ::..||:.:   ||    |::::. .||.  |....:..:.:|:|..::|
plant   667 ADRQKSQDDSANPEWSNHCDAVVR-NESD--EPKGLIQSDSMIVSSTKRCSGSSSERNLRDMDDE 728

  Fly   199 ----ELHEKPKVLVVS------------------PQQVMILYMNKLTPYERTE-ILTYPQIYFIG 240
                ..:..|..|..|                  |::      :..|.:|..: |:...|:..|.
plant   729 KVASSRNSSPSALSHSSDTGREHKEEDEEETSHGPEE------DPGTSFEDEDAIVVQEQVRQIQ 787

  Fly   241 A--------NAKKRPGVYGPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHK 297
            |        |.|.   |:..|.:.::.::..:: |.:..:|.||.:.:.:|..:|.:.|:|:|..
plant   788 AQEQDFETFNLKI---VHRKNRTGFEEDKNFHV-VLNSVIAGRYHVTEHLGSAAFSKAIQAHDLH 848

  Fly   298 THEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINL 362
            |...|.:||::|.|.|..|:.:||::|.::.:||..:..:::.::|||.||.|..|..|||..||
plant   849 TGIDVCVKIIKNNKDFFDQSLDEIKLLKYVNQHDPADKYHLLRLYDYFYFREHLLIVCELLKANL 913

  Fly   363 YELIKKNGFKGFSLQLVRKFAHSL-LQCLDA---LYKNDIIHCDMKPENVLLKQQGRSGIKVIDF 423
            ||..|.|...|..:........|: :|||:|   |:...:||||:||||:|:|...|..|||||.
plant   914 YEFQKFNRESGGEVYFTMPRLQSITIQCLEALNFLHGLGLIHCDLKPENILIKSYSRCEIKVIDL 978

  Fly   424 GSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACI 488
            ||||||...:.:|:|||.|||||||||..|.:.||:||||||||||.:|:.||..::.:..||.:
plant   979 GSSCFETDHLCSYVQSRSYRAPEVILGLPYDKKIDIWSLGCILAELCTGNVLFQNDSPATLLARV 1043

  Fly   489 IEVLGMPNKNILASSKRSKSFFSPKG--YPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLS 551
            |.::|..::.:||..:.:..:|:...  |.|    ...|:.:..||            |...||.
plant  1044 IGIIGSIDQEMLAKGRDTCKYFTKNHLLYER----NQESNNLEYLI------------PKKSSLR 1092

  Fly   552 KALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRLPRPPSSS 600
            :.|. ..|..|::|:...|:.|..||.:..||||||||  ..|..|.|:
plant  1093 RRLP-MGDQGFIDFVAYLLQVDPKKRPSAFEALKHPWL--TYPYEPISA 1138

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	136/392 (35%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	122/318 (38%)
AT3G17750	NP_188402.1	PKc_DYRK_like	827..1129	CDD:271035	122/318 (38%)
AT3G17750	NP_188402.1	S_TKc	827..1129	CDD:214567	122/318 (38%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810