DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and hipk1

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_012819927.1	Gene:	hipk1 / 734033	XenbaseID:	XB-GENE-987412	Length:	1218	Species:	Xenopus tropicalis

Alignment Length:	603	Identity:	179/603 - (29%)
Similarity:	279/603 - (46%)	Gaps:	111/603 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly   180 ENHTFLFHEQII--MSGQQKCELHEKPKVLVVSPQQVMILYMNKLTPYERTEILTYPQIYFIGAN 242
            :|...|.|...:  :...|||.|..|.:. |.|...|.|:       .||..::...:. .:||.
Frog   101 QNSQILTHRSNVPLLDPYQKCGLKRKSEE-VDSNGSVQII-------DERPPLMLQNRT-VVGAA 156

  Fly   243 AKKRPGVYGPNNSEYDNEQGAYIHVPHD---HVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVAL 304
            |......   ..|...|.:|.|..|.|:   .:...||:|:.:|:|:||||.|.:...|.|.||:
Frog   157 ATTTTVT---TKSSSSNGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAI 218

  Fly   305 KIVRNEKRFHRQAQEEIRILHHL--RRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIK 367
            ||::|...:.||.|.|:.||..|  ...|:|   |.:..::.|..:||||:.||:|..|||:.:|
Frog   219 KILKNHPSYARQGQIEVSILSRLSSENADEY---NFVRSYECFQHKNHTCLVFEMLEQNLYDFLK 280

  Fly   368 KNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRS--GIKVIDFGSSCFEN 430
            :|.|....|:.:|.....:...|..|....:||.|:||||::|....|.  .:|||||||:...:
Frog   281 QNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVS 345

  Fly   431 QRI-YTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGM 494
            :.: .||:|||:|||||:|||..:..|||||||||::|||..|..|:||.:|.||:..|.:..|:
Frog   346 KAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGL 410

  Fly   495 PNKNILASSKRSKSFFS---PKGYPRYCTVRTMS-DGMVVLIGGQSRRGKQRGPPC-----SKSL 550
            |.:.:|::..::..||:   ..|||.:   |..: |...:..|.:|:..::....|     ..::
Frog   411 PAEYLLSAGTKTSRFFNRDPDLGYPLW---RLKAPDEHEMETGIKSKEARKYIFNCLDDMAQVNM 472

  Fly   551 SKALDGCKDPL--------FLNFIRGCLEWDADKRLTPSEALKHPW--LRRRLPRPPSSS-SGCG 604
            |..|:| .|.|        :::.::..|..|||||:||.:.|.||:  :...|..|.|:. ..|.
Frog   473 STDLEG-TDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHPFVTMTHLLDFPHSNHVKSCF 536

  Fly   605 GVSGLCSSRNE----------------SPVTGQN------------RNFAAETTASSTSATSISL 641
            ....:|..|:.                :|.|..|            .|.|:...:|||:|.::||
Frog   537 QNMEICKRRSNMYDTVNQIKSPFTTHVAPNTSTNLTMSFNNQLNSVHNQASVLASSSTAAATLSL 601

  Fly   642 TIKRENSHSSLRLHHGAVPETDFKLIKSVPEGSSTATKEPMMNSDILP---------ESFRQTTV 697
            .    ||..||..:..|:          .|..:...|.....:..:.|         :.|:||.:
Frog   602 A----NSDVSLLNYQSAL----------YPPAAGPVTGVTQQSVSLQPGTTQLCTQTDPFQQTFI 652

  Fly   698 VSP-----------SKHS 704
            |.|           :|||
Frog   653 VCPPAFQAAGLQATTKHS 670

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	136/404 (34%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	123/336 (37%)
hipk1	XP_012819927.1	STKc_HIPK1	174..528	CDD:271130	127/360 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.940