Protein Alignment Dyrk3 and hipk1

DIOPT Version :10

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: XP_012819927.1
• Gene: hipk1 / 734033
• XenbaseID: XB-GENE-987412
• Length: 1218
• Species: Xenopus tropicalis
• Alignment Length: 603
• Identity: 179/603 - (29%)
• Similarity: 279/603 - (46%)
• Gaps: 111/603 - (18%)

  Fly   180 ENHTFLFHEQII--MSGQQKCELHEKPKVLVVSPQQVMILYMNKLTPYERTEILTYPQIYFIGAN 242
            :|...|.|...:  :...|||.|..|.:. |.|...|.|:       .||..::...:. .:||.
 Frog   101 QNSQILTHRSNVPLLDPYQKCGLKRKSEE-VDSNGSVQII-------DERPPLMLQNRT-VVGAA 156

  Fly   243 AKKRPGVYGPNNSEYDNEQGAYIHVPHD---HVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVAL 304
            |......   ..|...|.:|.|..|.|:   .:...||:|:.:|:|:||||.|.:...|.|.||:
 Frog   157 ATTTTVT---TKSSSSNGEGDYQLVQHEILCSMTNSYEVLEFLGRGTFGQVAKCWKRSTKEIVAI 218

  Fly   305 KIVRNEKRFHRQAQEEIRILHHL--RRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIK 367
            ||::|...:.||.|.|:.||..|  ...|:|   |.:..::.|..:||||:.||:|..|||:.:|
 Frog   219 KILKNHPSYARQGQIEVSILSRLSSENADEY---NFVRSYECFQHKNHTCLVFEMLEQNLYDFLK 280

  Fly   368 KNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRS--GIKVIDFGSSCFEN 430
            :|.|....|:.:|.....:...|..|....:||.|:||||::|....|.  .:|||||||:...:
 Frog   281 QNKFSPLPLKYIRPILQQVATALMKLKSLGLIHADLKPENIMLVDPVRQPYRVKVIDFGSASHVS 345

  Fly   431 QRI-YTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGM 494
            :.: .||:|||:|||||:|||..:..|||||||||::|||..|..|:||.:|.||:..|.:..|:
 Frog   346 KAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGL 410

  Fly   495 PNKNILASSKRSKSFFS---PKGYPRYCTVRTMS-DGMVVLIGGQSRRGKQRGPPC-----SKSL 550
            |.:.:|::..::..||:   ..|||.:   |..: |...:..|.:|:..::....|     ..::
 Frog   411 PAEYLLSAGTKTSRFFNRDPDLGYPLW---RLKAPDEHEMETGIKSKEARKYIFNCLDDMAQVNM 472

  Fly   551 SKALDGCKDPL--------FLNFIRGCLEWDADKRLTPSEALKHPW--LRRRLPRPPSSS-SGCG 604
            |..|:| .|.|        :::.::..|..|||||:||.:.|.||:  :...|..|.|:. ..|.
 Frog   473 STDLEG-TDMLAEKADRREYIDLLKKMLTIDADKRITPLKTLNHPFVTMTHLLDFPHSNHVKSCF 536

  Fly   605 GVSGLCSSRNE----------------SPVTGQN------------RNFAAETTASSTSATSISL 641
            ....:|..|:.                :|.|..|            .|.|:...:|||:|.::||
 Frog   537 QNMEICKRRSNMYDTVNQIKSPFTTHVAPNTSTNLTMSFNNQLNSVHNQASVLASSSTAAATLSL 601

  Fly   642 TIKRENSHSSLRLHHGAVPETDFKLIKSVPEGSSTATKEPMMNSDILP---------ESFRQTTV 697
            .    ||..||..:..|:          .|..:...|.....:..:.|         :.|:||.:
 Frog   602 A----NSDVSLLNYQSAL----------YPPAAGPVTGVTQQSVSLQPGTTQLCTQTDPFQQTFI 652

  Fly   698 VSP-----------SKHS 704
            |.|           :|||
 Frog   653 VCPPAFQAAGLQATTKHS 670

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	136/404 (34%)
hipk1	XP_012819927.1	STKc_HIPK1	174..528	CDD:271130	127/360 (35%)