DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and Dyrk2

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_006514109.3	Gene:	Dyrk2 / 69181	MGIID:	1330301	Length:	665	Species:	Mus musculus

Alignment Length:	545	Identity:	315/545 - (57%)
Similarity:	386/545 - (70%)	Gaps:	51/545 - (9%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 NYPGDIQILPIFDCCEISESIQAISLPNVTSPSKTKDVPGLFLRTISENSKSKSEPECESLISVK 174
            |..|.||:..:|:......::.......:|:..|| .:||:            .|.:.||:...:
Mouse   147 NSHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKT-GLPGV------------PERQLESIHRRQ 198

  Fly   175 ESSVMENHTFLFHEQIIMSGQQKCELHEKPKVLVVSPQQVMILYMNKLTPYERTEILTYPQIYFI 239
            .||               :..:..|...|.|...::|:|.|..||.|||.:|..||.:||:|||:
Mouse   199 GSS---------------TSLKSMEGMGKVKASPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFL 248

  Fly   240 GANAKKRPGVY-GPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVA 303
            |.|||||.|:. ||||..||::||:|:.|||||||||||:||:|||||||||:||||||.|:|||
Mouse   249 GPNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVA 313

  Fly   304 LKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKK 368
            ||:|||||||||||.||||||.|||:.||.||||:|||.:.||||||.|:||||||:||||||||
Mouse   314 LKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKK 378

  Fly   369 NGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRI 433
            |.|:||||.||||||||:|||||||:||.|||||:||||:||||||||.||||||||||:|:||:
Mouse   379 NKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRV 443

  Fly   434 YTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKN 498
            |||||||||||||||||.:||..||||||||||||||:|:.|.|||:|.|||||:||:||||::.
Mouse   444 YTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQK 508

  Fly   499 ILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFL 563
            :|.:|||:|:|.|.|||||||||.|:|||.|||.||:|||||.||||.|:....||.||.|||||
Mouse   509 LLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFL 573

  Fly   564 NFIRGCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAE 628
            :|::.|||||...|:||.:||:|||||||||:||                     ||: :.....
Mouse   574 DFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPP---------------------TGE-KTAVKR 616

  Fly   629 TTASSTSATSISLTIKRENSHSSLR 653
            .|.|:.:.||||......:|.|.||
Mouse   617 VTESTGAITSISKLPPPSSSASKLR 641

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	276/378 (73%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	235/312 (75%)
Dyrk2	XP_006514109.3	PKc_DYRK2_3	220..599	CDD:271126	276/378 (73%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	507	1.000	Domainoid score	I332
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H48437
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	1	1.000	-	-		otm43608
orthoMCL	1	0.900	-	-		OOG6_100394
Panther	1	1.100	-	-	LDO	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X888
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	12	11.810