Protein Alignment Dyrk3 and Dyrk2

DIOPT Version :10

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: XP_006514109.3
• Gene: Dyrk2 / 69181
• MGIID: 1330301
• Length: 665
• Species: Mus musculus
• Alignment Length: 545
• Identity: 315/545 - (57%)
• Similarity: 386/545 - (70%)
• Gaps: 51/545 - (9%)

  Fly   110 NYPGDIQILPIFDCCEISESIQAISLPNVTSPSKTKDVPGLFLRTISENSKSKSEPECESLISVK 174
            |..|.||:..:|:......::.......:|:..|| .:||:            .|.:.||:...:
Mouse   147 NSHGQIQVQQLFEDNSNKRTVLTTQPNGLTTVGKT-GLPGV------------PERQLESIHRRQ 198

  Fly   175 ESSVMENHTFLFHEQIIMSGQQKCELHEKPKVLVVSPQQVMILYMNKLTPYERTEILTYPQIYFI 239
            .||               :..:..|...|.|...::|:|.|..||.|||.:|..||.:||:|||:
Mouse   199 GSS---------------TSLKSMEGMGKVKASPMTPEQAMKQYMQKLTAFEHHEIFSYPEIYFL 248

  Fly   240 GANAKKRPGVY-GPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVA 303
            |.|||||.|:. ||||..||::||:|:.|||||||||||:||:|||||||||:||||||.|:|||
Mouse   249 GPNAKKRQGMTGGPNNGGYDDDQGSYVQVPHDHVAYRYEVLKVIGKGSFGQVVKAYDHKVHQHVA 313

  Fly   304 LKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKK 368
            ||:|||||||||||.||||||.|||:.||.||||:|||.:.||||||.|:||||||:||||||||
Mouse   314 LKMVRNEKRFHRQAAEEIRILEHLRKQDKDNTMNVIHMLENFTFRNHICMTFELLSMNLYELIKK 378

  Fly   369 NGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRI 433
            |.|:||||.||||||||:|||||||:||.|||||:||||:||||||||.||||||||||:|:||:
Mouse   379 NKFQGFSLPLVRKFAHSILQCLDALHKNRIIHCDLKPENILLKQQGRSSIKVIDFGSSCYEHQRV 443

  Fly   434 YTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKN 498
            |||||||||||||||||.:||..||||||||||||||:|:.|.|||:|.|||||:||:||||::.
Mouse   444 YTYIQSRFYRAPEVILGARYGMPIDMWSLGCILAELLTGYPLLPGEDEGDQLACMIELLGMPSQK 508

  Fly   499 ILASSKRSKSFFSPKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFL 563
            :|.:|||:|:|.|.|||||||||.|:|||.|||.||:|||||.||||.|:....||.||.|||||
Mouse   509 LLDASKRAKNFVSSKGYPRYCTVTTLSDGSVVLNGGRSRRGKLRGPPESREWGNALKGCDDPLFL 573

  Fly   564 NFIRGCLEWDADKRLTPSEALKHPWLRRRLPRPPSSSSGCGGVSGLCSSRNESPVTGQNRNFAAE 628
            :|::.|||||...|:||.:||:|||||||||:||                     ||: :.....
Mouse   574 DFLKQCLEWDPAVRMTPGQALRHPWLRRRLPKPP---------------------TGE-KTAVKR 616

  Fly   629 TTASSTSATSISLTIKRENSHSSLR 653
            .|.|:.:.||||......:|.|.||
Mouse   617 VTESTGAITSISKLPPPSSSASKLR 641

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	276/378 (73%)
Dyrk2	XP_006514109.3	PKc_DYRK2_3	220..599	CDD:271126	276/378 (73%)