DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dyrk3 and CLK4

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_065717.1	Gene:	CLK4 / 57396	HGNCID:	13659	Length:	481	Species:	Homo sapiens

Alignment Length:	375	Identity:	116/375 - (30%)
Similarity:	193/375 - (51%)	Gaps:	57/375 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly   241 ANAKKRPGVYGPNNSEYDNEQGAYIHVPHDHVAYRYEMLKIIGKGSFGQVIKAYDH-KTHEHVAL 304
            ::.:||      :.|..|:|:|..|....|.:..|||::..:|:|:||:|::..|| ....|||:
Human   130 SHRRKR------SRSIEDDEEGHLICQSGDVLRARYEIVDTLGEGAFGKVVECIDHGMDGMHVAV 188

  Fly   305 KIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKN 369
            |||:|..|:...|:.||::|.||...|..:....:.|.::|....|.||.||||.::.|:.||:|
Human   189 KIVKNVGRYREAARSEIQVLEHLNSTDPNSVFRCVQMLEWFDHHGHVCIVFELLGLSTYDFIKEN 253

  Fly   370 GFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVL-------------LKQQGR----SG 417
            .|..|.:..:|:.|:.:.|.::.|:.|.:.|.|:||||:|             :|:..|    :.
Human   254 SFLPFQIDHIRQMAYQICQSINFLHHNKLTHTDLKPENILFVKSDYVVKYNSKMKRDERTLKNTD 318

  Fly   418 IKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENES 482
            |||:||||:.::::...|.:.:|.||||||||...:.:..|:||:||||.|...|..:|...:..
Human   319 IKVVDFGSATYDDEHHSTLVSTRHYRAPEVILALGWSQPCDVWSIGCILIEYYLGFTVFQTHDSK 383

  Fly   483 DQLACIIEVLGMPNKNILASSKRSKSF---------FSPKGYPRYCTVRTMSDGMVVLIGGQSRR 538
            :.||.:..:||...::::..:::.|.|         .|..|  ||.
Human   384 EHLAMMERILGPIPQHMIQKTRKRKYFHHNQLDWDEHSSAG--RYV------------------- 427

  Fly   539 GKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPW 588
             ::|..|. |......|...:.|| :.:|..||:|..:|:|..|||:||:
Human   428 -RRRCKPL-KEFMLCHDEEHEKLF-DLVRRMLEYDPTQRITLDEALQHPF 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	116/375 (31%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	107/340 (31%)
CLK4	NP_065717.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..46
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	102..143		4/18 (22%)
		PKc_CLK1_4	146..475	CDD:271115	110/353 (31%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.810