DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dyrk3 and hipk3b

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	NP_001073628.1	Gene:	hipk3b / 569156	ZFINID:	ZDB-GENE-030131-82	Length:	1261	Species:	Danio rerio

Alignment Length:	672	Identity:	184/672 - (27%)
Similarity:	295/672 - (43%)	Gaps:	138/672 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   234 PQIYFIGANAKKRPGVYGPNNSEYDNEQGAYIHVPHD---HVAYRYEMLKIIGKGSFGQVIKAYD 295
            ||.  :|....|:.|..|       |..|.|..|.|:   .:...||:|..:|:|:||||:|.:.
Zfish   216 PQA--VGGGPAKQGGGSG-------NGDGDYQLVQHEMLCSLKNTYEVLDFLGRGTFGQVVKCWK 271

  Fly   296 HKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNHTCITFELLSI 360
            ..|.:.||:||::|...:.||.|.|:.||..| .::..:..|::..|:.|..|:|||:.||:|..
Zfish   272 RGTKDIVAVKILKNHPSYARQGQIEVGILARL-SNENADEHNLVRAFECFQHRSHTCLVFEMLEQ 335

  Fly   361 NLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQGRS--GIKVIDF 423
            |||:.:|:|.|....|:::|.....:...|..|....:||.|:||||::|....|.  .:|||||
Zfish   336 NLYDFLKQNKFSPLPLKVIRPILQQVATALKKLKGMGLIHADLKPENIMLVDPVRQPYRVKVIDF 400

  Fly   424 GSSCFENQRI-YTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLAC 487
            ||:...::.: .||:|||:|||||:|||..:..|||||||||::|||..|..|:||..|.||:..
Zfish   401 GSASHVSKAVCSTYLQSRYYRAPEIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGALEFDQIRY 465

  Fly   488 IIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMS-DGMVVLIGGQSRRGKQRGPPCSKSLS 551
            |.:..|:|.:::|....::..||..:....|.|.|..| :......|.:|:..::....|...::
Zfish   466 ISQTQGLPGEHLLNVGTKTSRFFCRESDSPYATWRLKSTEEHETETGLKSKEARKYIFSCLDDIA 530

  Fly   552 KA-----LDGCKDPL--------FLNFIRGCLEWDADKRLTPSEALKHPW--LRRRLPRPPSSS- 600
            ..     |:|| |.|        |:..::..|..||::|:.||:||.||:  ::..|..|.|:.
Zfish   531 HVNLVMNLEGC-DLLAEKVDRAEFVALLKKMLLIDAEERIAPSDALSHPFVTMQHLLDFPHSNHV 594

  Fly   601 SGCGGVSGLCSSRNES---------------PVTGQNRNF--------AAETTASSTSATSISLT 642
            ..|..:..:|.||..|               |.||...|.        ...|.|.::||.::
Zfish   595 KSCFHIMDVCCSRPGSYESHSRTKAQFVRTVPSTGAASNLTLPFCKVTGIHTQALASSAPTV--- 656

  Fly   643 IKRENSHSSLRLHHGAV-------------PET--------------DFKLIKSVPEGSSTATKE 680
                 .|..:.|..|:.             |.|              ...:..:||..:..:..:
Zfish   657 -----MHPGIPLQTGSAQFGDSFQQALILCPPTIQGLPPNPNKPAGYSVSMESTVPLVTQASAIQ 716

  Fly   681 PMM--------------NSDILPESFRQTTVVSPSKHSADSGGMSCLSAVDV-GPSRYYPYMNNN 730
            |:.              ...||..::.|.|.|:|...||     :.|::..| ||.|...:...:
Zfish   717 PLQIRPGVITQQGWSNRAQQILVPTWPQVTPVAPVAPSA-----TTLASEPVAGPQRLADWGKVH 776

  Fly   731 ENNRLFSSSL--------NSSANS--------LSHLEQATKLDALGEYSASTTPNLLSKN--TGY 777
            .:...:||.:        |..|.|        ::|:        :....|:...|..|.|  ..:
Zfish   777 SHGNHYSSMMPHHQPLLTNPMAMSAHQPISIGIAHV--------VWPQPAANKRNKPSSNRCNNF 833

  Fly   778 SFNSGSINIDVAQESLVNIASN 799
            ..::.|.|:......:||.|.|
Zfish   834 MHSTNSQNVSCQSPKMVNSAKN 855

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	131/376 (35%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	120/331 (36%)
hipk3b	NP_001073628.1	STKc_HIPK3	251..580	CDD:271131	120/330 (36%)
hipk3b	NP_001073628.1	S_TKc	252..580	CDD:214567	120/329 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.940