Protein Alignment Dyrk3 and hipk2

DIOPT Version :10

• Sequence 1: NP_001033810.1
• Gene: Dyrk3 / 3885567
• FlyBaseID: FBgn0027101
• Length: 828
• Species: Drosophila melanogaster
• Sequence 2: XP_005159048.2
• Gene: hipk2 / 557551
• ZFINID: ZDB-GENE-031125-4
• Length: 1230
• Species: Danio rerio
• Alignment Length: 536
• Identity: 166/536 - (30%)
• Similarity: 254/536 - (47%)
• Gaps: 100/536 - (18%)

  Fly   259 NEQGAYIHVPHD---HVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEE 320
            |.:|.|..:.|:   .:...||:|:.:|:|:||||:|.:...|.|.||:||::|...:.||.|.|
Zfish   200 NSEGDYQLLQHEVLCSMTNTYEVLEFLGRGTFGQVVKCWKRGTSEIVAIKILKNHPSYARQGQIE 264

  Fly   321 IRILHHLRRH--DKYNTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFA 383
            :.||..|...  |.|   |.:..::.|..:||||:.||:|..|||:.:|:|.|....|:.:|...
Zfish   265 VSILARLSTESADDY---NFVRAYECFQHKNHTCLVFEMLEQNLYDFLKQNKFSPLPLKYIRPIL 326

  Fly   384 HSLLQCLDALYKNDIIHCDMKPENVLLKQQGRS--GIKVIDFGSSCFENQRI-YTYIQSRFYRAP 445
            ..:...|..|....:||.|:||||::|....|.  .:|||||||:...::.: .||:|||:||||
Zfish   327 QQVATALMKLKSLGLIHADLKPENIMLVDPARQPYRVKVIDFGSASHVSKAVCSTYLQSRYYRAP 391

  Fly   446 EVILGGKYGRAIDMWSLGCILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFF 510
            |:|||..:..|||||||||::|||..|..|:||.:|.||:..|.:..|:|.:.:|::..::..||
Zfish   392 EIILGLPFCEAIDMWSLGCVIAELFLGWPLYPGASEYDQIRYISQTQGLPAEYLLSAGTKTTRFF 456

  Fly   511 S---PKGYPRYCTVRTMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPL----------- 561
            :   ...||.: .::|..|       .::..|.:     ||...|.:..|.|.:
Zfish   457 NRDPDSTYPLW-RLKTPED-------HEAETGIK-----SKEARKYIFNCLDDMAQVNMTTDLEG 508

  Fly   562 ------------FLNFIRGCLEWDADKRLTPSEALKHPW--LRRRLPRPPSSS-SGCGGVSGLCS 611
                        |::.:...|..|||||:||.|.|.||:  :...|..|.|:. ..|.....:|.
Zfish   509 SDMLAEKADRREFIDLLTKMLTIDADKRITPIETLNHPFVTMTHLLDFPHSTHVKSCFQNMEICK 573

  Fly   612 SR-------NES---------PVTGQN------------RNFAAETTASSTSATSISLTIKRENS 648
            .|       |:|         |.|..|            .:.|.....|||||| :|||    |.
Zfish   574 RRVNMYDTVNQSKTPFITHVAPSTSTNLTMTFNNQLNTVHSQATNLAPSSTSAT-LSLT----NP 633

  Fly   649 HSSLRLHHGAVPETDFKLIKSV-PEGSSTATKEPMMNSDILPESFRQTTVV----------SPSK 702
            ..|:..:..|:.:.....:.:| |.........|.:.: ..|:.|:|..:|          ||||
Zfish   634 DVSILNYQSALYQPSAAPMAAVAPRTMPLQPGAPQLCA-ARPDPFQQALIVCPPGFQGLQASPSK 697

  Fly   703 HSADSGGMSCLSAVDV 718
            |:..|..|.  :||.:
Zfish   698 HTGYSVRME--NAVPI 711

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	126/365 (35%)
hipk2	XP_005159048.2	None