DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Dyrk3 and dyrk3

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_012815970.1	Gene:	dyrk3 / 493520	XenbaseID:	XB-GENE-1008699	Length:	568	Species:	Xenopus tropicalis

Alignment Length:	448	Identity:	271/448 - (60%)
Similarity:	337/448 - (75%)	Gaps:	7/448 - (1%)

- Green bases have known domain annotations that are detailed below.

  Fly   205 KVLVVSPQQVMILYMNKLTPYERTEILTYPQIYFIGANAKKRPGVY-GPNNSEYDNEQGAYIHVP 268
            |...::|.|.:..|.::|:.||..||.::.:|||:|.|||||.||. ||||..||::||.|..||
Frog   118 KATYLTPDQAVKQYKHQLSAYELQEISSFSEIYFVGPNAKKRQGVVGGPNNGGYDDDQGGYNLVP 182

  Fly   269 HDHVAYRYEMLKIIGKGSFGQVIKAYDHKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKY 333
            |||||||||:||:|||||||||.|.||||.|:|:|||:|||||||||||.||||||.||::.||.
Frog   183 HDHVAYRYEVLKVIGKGSFGQVAKVYDHKLHQHLALKMVRNEKRFHRQAAEEIRILEHLKKQDKT 247

  Fly   334 NTMNIIHMFDYFTFRNHTCITFELLSINLYELIKKNGFKGFSLQLVRKFAHSLLQCLDALYKNDI 398
            .:||:|||.:.||||||.|:||||||:|||||||:|.|:|||||||||||||:||||:|||:|.|
Frog   248 GSMNVIHMLESFTFRNHICMTFELLSMNLYELIKRNKFQGFSLQLVRKFAHSILQCLEALYRNKI 312

  Fly   399 IHCDMKPENVLLKQQGRSGIKVIDFGSSCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLG 463
            ||||:||||:||||||||||||||||||||::||:|||||||||||||||||.:||..|||||.|
Frog   313 IHCDLKPENILLKQQGRSGIKVIDFGSSCFDHQRVYTYIQSRFYRAPEVILGSRYGMPIDMWSFG 377

  Fly   464 CILAELLSGHALFPGENESDQLACIIEVLGMPNKNILASSKRSKSFFSPKGYPRYCTVRTMSDGM 528
            |||.|||:|:.|||||:|.|||||::|:||.|...:|..:||:|:|.:.|||||||||.|:.:|.
Frog   378 CILVELLTGYPLFPGEDEGDQLACMMELLGAPPPKLLEQAKRAKNFINSKGYPRYCTVTTLPNGT 442

  Fly   529 VVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHPWLRRRL 593
            .||.|.:|||||.||.|.||....||.||:|.||::|::|||.||...|:|||:||:|.|:.:||
Frog   443 TVLNGSRSRRGKMRGAPGSKDWVAALKGCEDSLFIDFLKGCLTWDPVARMTPSQALRHQWISKRL 507

  Fly   594 PRPPSSSSGCG-GVSGLCSS-----RNESPVTGQNRNFAAETTASSTSATSISLTIKR 645
            |:|..:....| .:|...||     ....||.|......|.....|..:..:...:.:
Frog   508 PKPSVTEKASGKRISSQTSSFPGIGSKLPPVVGVANKLRANLMNDSNGSIPLRTVLPK 565

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	256/378 (68%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	219/312 (70%)
dyrk3	XP_012815970.1	PKc_DYRK2_3	124..503	CDD:271126	256/378 (68%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	503	1.000	Domainoid score	I342
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D162948at33208
OrthoFinder	1	1.000	-	-		FOG0000895
OrthoInspector	1	1.000	-	-		otm48768
Panther	1	1.100	-	-	O	PTHR24058
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R968
SonicParanoid	1	1.000	-	-		X888
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	9	9.050