DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Dyrk3 and prpf4ba

DIOPT Version :9

Sequence 1:	NP_001033810.1	Gene:	Dyrk3 / 3885567	FlyBaseID:	FBgn0027101	Length:	828	Species:	Drosophila melanogaster
Sequence 2:	XP_017207374.1	Gene:	prpf4ba / 393182	ZFINID:	ZDB-GENE-040426-947	Length:	986	Species:	Danio rerio

Alignment Length:	721	Identity:	169/721 - (23%)
Similarity:	292/721 - (40%)	Gaps:	181/721 - (25%)

- Green bases have known domain annotations that are detailed below.

  Fly     5 QEKKNNHIELSETPATDKNNLNTTHLENTQLSKALSP-----PTSLPQIQIQMINQNLTHTGIAQ 64
            ::||.....|.|..:..:|...:......:||..:.|     |..||.:|
Zfish   315 RDKKPVKAPLKEVSSGKENRSPSRKQGPDRLSPTVQPRSHRSPERLPVVQ--------------- 364

  Fly    65 NNTEKANR------------HQYRDSGLQYLTRCFEPLAMLND----------SKEDFPTQPSNN 107
             ||::|:|            .:.|...::...|..|...:.:|          .:||.|:..|..
Zfish   365 -NTDRASRQDRSTCHNRSPPRRGRSRSVERRRREEERQRLSSDRMRSRDMAGAHREDSPSISSRR 428

  Fly   108 IANYPGDIQILPI--------------------FDCCEISESIQAISLPNVTSPSKTKDVPGLFL 152
            ..|:.      |:                    .|..:..:.:::.|.......||.::  .:|.
Zfish   429 RLNHS------PLRRRSRSPRRRSSRSPLRHRERDRMDRRQPVRSRSQERRRRRSKERE--DMFK 485

  Fly   153 RTISENSKSKSEPECESLIS-----------------VKESSVMENHTFLFHEQIIMSGQQKCEL 200
            .::||..|::.|...|.::.                 ::..::|:.:..: :|...|||...
Zfish   486 GSLSEGMKAEQEDSDEEVLEDYDVDEEDEEALIEQRRLQRLAIMQKYKPV-NEDSNMSGLSD--- 546

  Fly   201 HEKPKVLV----VSPQQVMILYMNKLTPYERTEILTYPQ----IYFI------GANAKKRP---- 247
            |..|:...    .||..::......:..||:..:.|:..    .|.:      |||:||.|
Zfish   547 HGSPQSSTHSRSPSPDDILERVAADVKAYEQENLDTFEDNVKAKYSLVSQEKNGANSKKPPAPDM 611

  Fly   248 --------------------GV---YGPNNSEYDN--EQGAYIHVPHDHVA-YRYEMLKIIGKGS 286
                                |:   :..|.|..||  :...|..|....|. .||.:....|:|.
Zfish   612 FTESDDMFAAYFDSARLRAAGIGKDFKENPSLRDNWTDAEGYYRVNIGEVLDKRYAVYGYTGQGV 676

  Fly   287 FGQVIKAYD-HKTHEHVALKIVRNEKRFHRQAQEEIRILHHLRRHDKYNTMNIIHMFDYFTFRNH 350
            |..||:|.| .:.::.||:||:||.:...:...:|:..|..|...|..:..:.:.:|.:|..:.|
Zfish   677 FSNVIRARDLARANQEVAVKIIRNNEMMQKTGLKELEFLKKLNDADADDKFHCLRLFRHFYHKQH 741

  Fly   351 TCITFELLSINLYELIKKNGFK-GFSLQLVRKFAHSLLQCLDALYKNDIIHCDMKPENVLLKQQG 414
            .|:.||.||:||.|:::|.|.. |..::.||.::..|...|..|.:.:|:|.|:||:|:|:.:.
Zfish   742 LCLVFEPLSMNLREVLRKYGKDVGLHIKAVRSYSQQLFLALKHLKRCNILHADIKPDNILVNEP- 805

  Fly   415 RSGIKVIDFGS-SCFENQRIYTYIQSRFYRAPEVILGGKYGRAIDMWSLGCILAELLSGHALFPG 478
            ::.:|:.|||| |...:..|..|:.||||||||:|:|..|...|||||:||.|.||.:|..||||
Zfish   806 KTILKLCDFGSASHVADNDITPYLVSRFYRAPEIIIGKSYDYGIDMWSVGCTLYELYTGKILFPG 870

  Fly   479 ENESDQLACIIEVLG-MPNKNILASSKRSKSFFSPKGYPR--------------------YCTVR 522
            :..:..|...:::.| :|||.|      .|..|..:.:.:                    ..|:.
Zfish   871 KTNNHMLKLNMDLKGKLPNKMI------RKGLFKDQHFDQNLNFLYTEVDKVTEREKITVMSTIN 929

  Fly   523 TMSDGMVVLIGGQSRRGKQRGPPCSKSLSKALDGCKDPLFLNFIRGCLEWDADKRLTPSEALKHP 587
            ...|..:.::|.|:....||         |.:...||     .:...|..|..||:|.::||:||
Zfish   930 PTKDLSMDMVGRQALPEDQR---------KKVGQLKD-----LLDQILMLDPAKRITINQALQHP 980

  Fly   588 WLRRRL 593
            :::.|:
Zfish   981 FIQERI 986

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Dyrk3	NP_001033810.1	PKc_DYRK2_3	211..589	CDD:271126	124/441 (28%)
Dyrk3	NP_001033810.1	S_TKc	276..589	CDD:214567	104/336 (31%)
prpf4ba	XP_017207374.1	None

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_KOG0667
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	2	1.810